RO6889678 synthesis
- Product Name:RO6889678
- CAS Number:1578153-27-1
- Molecular formula:C21H20ClFN4O5S
- Molecular Weight:494.92
![3-Morpholinecarboxylic acid, 4-[[6-(2-chloro-4-fluorophenyl)-3,6-dihydro-5-(methoxycarbonyl)-2-(2-thiazolyl)-4-pyrimidinyl]methyl]-, (3S)-](/CAS/20210305/GIF/1571212-55-9.gif)
1571212-55-9
0 suppliers
inquiry
1578153-27-1
15 suppliers
inquiry
Yield:1578153-27-1 94%
Reaction Conditions:
in tert-butyl methyl ether at 20; for 4 h;Solvent;
Steps:
1 Example 1:(S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydrogen Pyrimidin-4-yl)methyl)morpholine-3-carboxylic acid Preparation
(25S)-4-((6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6) was sequentially added to a 25 mL jar. -dihydropyrimidin-4-yl)methyl)morpholine-3-carboxylic acid (1 g) and ethanol (5 mL),The mixture was stirred at room temperature for 4 hours and filtered.The filtrate is concentrated under reduced pressure to remove the solvent.Obtained (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-di Hydroxymidin-4-yl)methyl)morpholine-3-carboxylic acid was a yellow foamy solid (0.46 g, 92%).Chiral purity 95%.
References:
CN107674072,2018,A Location in patent:Paragraph 0199; 0200; 0201; 0206; 0207
1578155-69-7
1 suppliers
inquiry
106825-79-0
125 suppliers
$45.00/10g
1578153-27-1
15 suppliers
inquiry
1187929-04-9
76 suppliers
$29.00/250mg
1578155-69-7
1 suppliers
inquiry
1578153-27-1
15 suppliers
inquiry
247037-77-0
7 suppliers
inquiry
1578153-27-1
15 suppliers
inquiry
1579251-94-7
4 suppliers
inquiry
1578153-27-1
15 suppliers
inquiry