(S)-1-Boc-3-methylpiperazine synthesis
- Product Name:(S)-1-Boc-3-methylpiperazine
- CAS Number:147081-29-6
- Molecular formula:C10H20N2O2
- Molecular Weight:200.28
24424-99-5
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147081-29-6
At 0 °C, (S)-2-methylpiperazine (400 mg) was dissolved in dichloromethane (20 mL) and di-tert-butyl dicarbonate (871 mg) was slowly added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction was quenched with deionized water (20 mL) followed by extraction with dichloromethane (2 x 40 mL). The organic phases were combined, washed with saturated sodium chloride solution (40 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford (S)-4-N-tert-butoxycarbonyl-2-methylpiperazine as a white solid (669 mg, 84% yield).
74879-18-8
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147081-29-6
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Yield:147081-29-6 94%
Steps:
202.1 Tert-Butyl (3S)-4-(6-ethylthiopheno[3,2-e]pyrimidin-4-yl)-3-methylpiperazinecarboxylate
Step 1. (S)-2-Methylpiperazine was converted to 1-BOC-3-(S)-methylpiperazine according to Example 192. Yield=94%.
References:
US2003/153556,2003,A1
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147081-29-6
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