Sodium sarcosinate synthesis
- Product Name:Sodium sarcosinate
- CAS Number:4316-73-8
- Molecular formula:C3H8NNaO2
- Molecular Weight:113.09
109-83-1
4316-73-8
General procedure for the synthesis of sodium N-methylglycinate from N-methyl-2-hydroxyethylamine: 10 g of Cu/Ni based Nguyenne catalyst (Degussa AG, BOO 111, on a dry matter basis) was placed as an aqueous suspension in a 600 ml autoclave, which was equipped with a stirrer, a pressure control valve, and a jacketed heating unit. Subsequently 75 g of N-methyl-2-hydroxyethylamine and 204 g of 20 wt% sodium hydroxide solution were added. After sealing the autoclave, the reaction mixture was warmed up to 160°C by jacket heating. During this process, the pressure of the hydrogen gas produced was gradually increased and the system pressure was maintained at 10 bar (absolute pressure) by adjusting the opening of the pressure control valve. After 4 hours of reaction, gas release was completely stopped and the reactor was cooled to 90°C. After stopping stirring, the catalyst precipitated within 1 h. A portion of the supernatant with sodium N-methylglycinate solution was removed from the autoclave via piping. The catalyst was retained in the reactor and could be reused for the next batch of reaction. For each subsequent cycle, the catalyst suspension remaining in the reactor is mixed with specified amounts of N-methyl-2-hydroxyethylamine and sodium hydroxide solution and the reaction is initiated by heating. In addition to the initial batch, 270 g of colorless sodium N-methylglycinate solution was obtained for each cycle at a concentration of 40.0 wt% (equivalent to 97.2% of the theoretical yield).
109-83-1
455 suppliers
$10.00/25ml
4316-73-8
264 suppliers
$147.00/25ML
Yield:4316-73-8 97.2%
Reaction Conditions:
with sodium hydroxide;Cu/Ni Raney catalyst in water at 160; under 7500.75 Torr; for 4 h;
Steps:
1
10 g (calculated on the basis of the dry substance) of a Cu/Ni-based Raney catalyst (Degussa AG, BOO 111) was placed first as a suspension in water in a 600 ml autoclave with stirrer, pressure control valve and jacket heating and 75 g N-methyl-ethanolamine as well as 204 g of a 20% by weight sodium hydroxide solution were added. The autoclave was closed and the contents were heated to a temperature of 160° C. with the aid of the jacket heating. An increasing pressure of hydrogen was generated in this process which was kept at 10 bar (absolute) by the controlled opening of the pressure control valve. The release of gas was completely finished after 4 hours and the reactor was cooled to 90° C. After the stirrer was switched off, the catalyst sedimented within one hour and a portion of the supernatant clear solution of Na sarcosinate was moved from the autoclave through a plunge pipe. The catalyst remained in the reactor and could be used again in further batches.For each further cycle the suspension of catalyst remaining in the reactor was admixed with the said amounts of N-methylethanolamine and sodium hydroxide solution and the reaction was started by heating.With the exception of the initial batch, 270 g of a colourless solution of Na sarcosinate containing 40.0% by weight (corresponds to a yield of 97.2% of theory) was obtained per cycle.
References:
US2009/163739,2009,A1 Location in patent:Page/Page column 2
5616-32-0
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$36.67/1g
4316-73-8
264 suppliers
$147.00/25ML
107-97-1
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$5.00/100mg
4316-73-8
264 suppliers
$147.00/25ML