Diclofenac sodium synthesis
- Product Name:Diclofenac sodium
- CAS Number:15307-79-6
- Molecular formula:C14H10Cl2NNaO2
- Molecular Weight:318.13
15307-78-5
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$39.00/10mg
15307-79-6
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$14.00/5g
Yield:15307-79-6 96.1%
Reaction Conditions:
with sodium hydroxide in water;N,N-dimethyl-formamide at 80; for 24 h;
Steps:
1.2; 2.2; 3.2 (2) Synthesis of diclofenac sodium
25 g (0.08 mol) of Compound C, 160 mL of N,N-dimethylformamide were added to a three-necked flask, and the mixture was stirred and heated to 80 °C. After adding 8g (0.2mol) of NaOH and 35g of water to form a solution, continue the reaction for 24h, After completion of the reaction, the solvent was distilled off under reduced pressure, the residue was dissolved by heating with 200mL of water, decolorized with charcoal, suction filtered, the filtrate was cooled in an ice-water bath crystallization, filtration, The white crystalline powder diclofenac sodium was dried to 24.6 g, the yield was 96.1%, and the content determined by HPLC was 98.2%. The overall yield of the above reaction was 90.5%.
References:
CN109553544,2019,A Location in patent:Paragraph 0017-0026
15362-40-0
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15307-79-6
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87-65-0
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35613-44-6
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$35.00/250mg
15307-79-6
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40311-72-6
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$437.00/1g
35613-44-6
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$35.00/250mg
15307-79-6
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$14.00/5g
2444-36-2
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$5.00/25g
608-31-1
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71-36-3
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15307-79-6
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$14.00/5g