Sts 64 synthesis
- Product Name:Sts 64
- CAS Number:24284-84-2
- Molecular formula:C21H27NO2
- Molecular Weight:325.44
Yield: 92%
Reaction Conditions:
Stage #1:acetonitrile with n-butyllithium in tetrahydrofuran at -40;
Stage #2:estrone 3-methyl ether in tetrahydrofuran at -40; for 1.5 h;
Stage #3: with water in tetrahydrofuran
Steps:
2
Butyllithium (24.5, 245 mmol) was added to THF (250 ml) at minus 40° C. Acetonitrile (26.5 ml, 480 mmol) was added while stirring. A solution of II (16.0 g, 56 mmol) in THF (300 ml) was added dropwise to the reaction mixture. After 90 minutes of stirring at -40° C. the reaction was quenched by adding water (125 ml). The organic layer was removed in vacuo. Ice water (500 ml) was added to the remaining aqueous layer. The resulting precipitate was filtered, washed with water (500 ml) and dried in vacuo. Yield: 15.5 g (51 mmol, 92%).
References:
HEYL CHEMISCH-PHARMAZEUTISCHE FABRIK GMBH & CO. KG US2010/298585, 2010, A1 Location in patent:Page/Page column 3
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