TRANS-4-(BOC-AMINO)CYCLOHEXYL METHANESULFONATE synthesis
- Product Name:TRANS-4-(BOC-AMINO)CYCLOHEXYL METHANESULFONATE
- CAS Number:177545-89-0
- Molecular formula:C12H23NO5S
- Molecular Weight:293.38
124-63-0
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$10.00/5g
111300-06-2
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$6.00/1g
177545-89-0
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$500.54/5MG
Yield:177545-89-0 100%
Reaction Conditions:
Stage #1: methanesulfonyl chloride;(trans-4-hydroxy-cyclohexyl)-carbamic acid tert-butyl esterwith triethylamine in dichloromethane at 0 - 20; for 2.5 h;
Stage #2: with Sodium hydrogenocarbonate in dichloromethane;lithium hydroxide monohydrate; for 0.5 h;
Steps:
1.F; 7A.B
Methanesulfonyl chloride (135 μl, 1.74 mmol) was added to a cooled (ice bath, 0-4° C.), stirred solution of trans-(4-hydroxycyclohexyl)carbamic acid tert-butyl ester (0.25 g, 1.16 mmol) and triethylamine (243 μl, 1.74 mmol) in dichloromethane (10 ml). Following the addition the reaction was stirred at this temperature for 30 minutes before being allowed to warm to ambient temperature. After stirring at ambient temperature for 2 hours, aqueous sodium hydrogen carbonate (10 ml) was added, followed by vigorous stirring for 30 minutes. The reaction was diluted with dichloromethane (20 ml) and aqueous sodium hydrogen carbonate (20 ml) and after partitioning the organic phase was washed with water (20 ml), dried (magnesium sulphate) and evaporated to dryness under reduced pressure to yield methanesulfonic acid trans-4-tert-butoxycarbonylaminocyclohexyl ester (340 mg, 100%).
References:
US2008/45566,2008,A1 Location in patent:Page/Page column 5; 8
27489-62-9
470 suppliers
$5.00/5g
177545-89-0
18 suppliers
$500.54/5MG
24424-99-5
863 suppliers
$13.50/25G
27489-62-9
470 suppliers
$5.00/5g
124-63-0
0 suppliers
$10.00/5g
177545-89-0
18 suppliers
$500.54/5MG
24424-99-5
863 suppliers
$13.50/25G
177545-89-0
18 suppliers
$500.54/5MG
24424-99-5
863 suppliers
$13.50/25G
27489-62-9
470 suppliers
$5.00/5g
177545-89-0
18 suppliers
$500.54/5MG