Valdecoxib 3'-Sulfonyl Chloride IMpurity synthesis
- Product Name:Valdecoxib 3'-Sulfonyl Chloride IMpurity
- CAS Number:1373038-57-3
- Molecular formula:C16H12ClNO3S
- Molecular Weight:333.79
37928-17-9
312 suppliers
$7.00/1g
1373038-57-3
12 suppliers
inquiry
Yield:1373038-57-3 80 g
Reaction Conditions:
with chlorosulfonic acid;iron(III) chloride;sulfuric acid at -10 - 80; for 10.5 h;Reagent/catalyst;Temperature;
Steps:
1 Example 1 Preparation of Compound of Formula 3
100 g of the compound of formula 2,300mL of concentrated sulfuric acid and 70g of anhydrous ferric chloride,well mixed,At a temperature of -10°C,Slowly add 500mL of chlorosulfonic acid,After the addition is completed,Stir for 0.5h; heat up to 80 ° C for 10h; then cool down to below 30 ° C,The reaction solution was slowly poured into 1000 mL of an ice water mixture.Dichloromethane extraction (500mL*2),The organic phase was dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated to dryness.The product containing the compound of formula 3 is obtained, about 80 g.
References:
CN108047155,2018,A Location in patent:Paragraph 0025; 0028
37928-17-9
312 suppliers
$7.00/1g
1373038-57-3
12 suppliers
inquiry
509074-26-4
119 suppliers
$15.00/250mg
52201-28-2
1 suppliers
inquiry
1373038-57-3
12 suppliers
inquiry
103-79-7
0 suppliers
$31.00/10mg
1373038-57-3
12 suppliers
inquiry
857259-65-5
0 suppliers
inquiry
1373038-57-3
12 suppliers
inquiry