| Identification | More | [Name]
Methanesulfonyl chloride | [CAS]
124-63-0 | [Synonyms]
AKOS BBS-00004350
MESYL CHLORIDE
METHANESULFONIC ACID CHLORIDE
METHANESULFONYL CHLORIDE
METHANESULPHONYL CHLORIDE
METHYLSULFOCHLORIDE
METHYLSULFONYL CHLORIDE
MSC
MSCI
MSCL
CH3SO2Cl
Chloro methyl sulfone
chloromethylsulfone
methanesulfonyl
Methanesulfuryl chloride
methanesulfurylchloride
Metylsulfonylchloride
Methane sulfonic Chloride
METHANESULFONYL CHLORIDE, 99+%
METHANESULFONYL CHLORIDE, 99.7+% (CMS) ( | [EINECS(EC#)]
204-706-1 | [Molecular Formula]
CH3ClO2S | [MDL Number]
MFCD00007454 | [Molecular Weight]
114.55 | [MOL File]
124-63-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale yellow corrosive liquid. Unpleasant, pungent odor. | [Melting point ]
-33°C | [Boiling point ]
60 °C/21 mmHg (lit.) | [density ]
1.48 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.452(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store at R.T. | [form ]
Liquid | [color ]
Clear | [Water Solubility ]
Miscible with alcohol, ether and organic solvents. Immiscible with water. | [Sensitive ]
Moisture Sensitive | [Merck ]
14,5955 | [BRN ]
506297 | [CAS DataBase Reference]
124-63-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Methanesulfonyl chloride(124-63-0) | [EPA Substance Registry System]
124-63-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,T,C | [Risk Statements ]
R24/25:Toxic in contact with skin and if swallowed .
R26:Very Toxic by inhalation.
R34:Causes burns.
R37:Irritating to the respiratory system.
R35:Causes severe burns.
R22:Harmful if swallowed.
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes . | [RIDADR ]
UN 3246 6.1/PG 1
| [WGK Germany ]
2
| [RTECS ]
PB2790000
| [Hazard Note ]
Toxic/Corrosive | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
I | [HS Code ]
29049095 | [Hazardous Substances Data]
124-63-0(Hazardous Substances Data) |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Thionyl chloride-->Chlorine-->Thiourea-->Mineral oil-->Methanesulfonic acid-->METHYL MERCAPTAN-->Dimethyl disulfide | [Preparation Products]
1,3-Propane sultone-->(3S,4S)-(-)-1-BENZYL-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE-->(-)-DIOP-->4-(Methylsulfonamido)aniline-->(4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE-->3-N-Boc-aminopyrrolidine-->N-(3-Aminophenyl)methanesulfamide-->(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine-->1-(Tetrahydro-2H-pyran-4-yl)hydrazine-->Pergolide-->Gestodene-->5-Aminosalicylic acid-->3-(METHANESULFONYLAMINO)BENZOIC ACID-->2-(Methanesulfonylamino)phenylboronic acid-->ETHYL METHANESULFONYLACETATE-->Fexofenadine-->(S)-3-(Boc-amino)pyrrolidine-->TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE-->Nimesulide-->(2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE-->Raloxifene-->Stavudine-->(4S)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-en-1-one-->LIMAPROST-->Aztreonam-->Amsacrine-->Cefcapene pivoxil-->optically active amino thioacetes-->Methyl methanesulfonate-->alkyl phenylsufonate-->Methanesulfonamide-->SAPERCONAZOLE-->OLSALAZINE-->9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt-->Halobetasol propionate-->4-(METHANESULFONYLAMINO)BENZOIC ACID-->Busulfan-->2-Amino-4,5-difluorobenzoic acid-->11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate-->Ethyl methanesulfonate |
| Hazard Information | Back Directory | [General Description]
A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption. | [Reactivity Profile]
METHANESULFONYL CHLORIDE reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
Chemical intermediate in various
industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical
stabilizer. Laboratory chemical. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
Medical observation is recommended for 24 to
48 hours after breathing overexposure, as pulmonary edema
may be delayed. As first aid for pulmonary edema, a doctor
or authorized paramedic may consider administering a drug
or other inhalation therapy.
| [Shipping]
UN3246 Methanesulfonyl chloride, Hazard Class
6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive
material, Inhalation Hazard Zone B. | [Incompatibilities]
Vapors may form explosive mixture with
air. Slowly reacts with water, releasing toxic and corrosive
hydrogen chloride gas. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, DMSO,
ethers, strong acids, strong bases. | [Chemical Properties]
Colorless to yellow liquid | [Chemical Properties]
Pale yellow corrosive liquid. Unpleasant, pungent odor. | [Waste Disposal]
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed | [Uses]
Methanesulfonyl chloride can be used for the mesylation of primary alcohols to synthesize the corresponding methanesulfonates. It may also be used for the conversion of amines to the corresponding sulfonamides. | [Uses]
In the synthesis of photographic and agricultural chemicals, pharmaceutical intermediates. As a stabilizer; catalyst; curing and chlorinating agent; precursor to methanesulfonic acid. | [Uses]
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones. | [Purification Methods]
Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.] |
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