| Identification | More | [Name]
Disodium hydrogenorthophosphate | [CAS]
7558-79-4 | [Synonyms]
BUFFER CONCENTRATE I FROM DI-SODIUM HYDROGEN PHOSPHATE
BUFFER CONCENTRATE II FROM DI-SODIUM HYDROGEN PHOSPHATE
BUFFER SOLUTION
BUFFER SOLUTION, PH 2.5
BUFFER SOLUTION, PH 7.0
DIBASIC SODIUM PHOSPHATE
DINATRII PHOSPHAS ANHYDRICUS
DINATRII PHOSPHAS DIHYDRICUS
DI-SODIUM HYDROGEN ORTHOPHOSPHATE
DI-SODIUM HYDROGEN ORTHOPHOSPHATE 2H2O
DI-SODIUM HYDROGEN ORTHOPHOSPHATE 2-HYDRATE
DI-SODIUM HYDROGEN ORTHOPHOSPHATE DIBASIC
DI-SODIUM HYDROGEN ORTHOPHOSPHATE DIHYDRATE
DISODIUM HYDROGEN PHOSPHATE
DI-SODIUM HYDROGEN PHOSPHATE 2H2O
DI-SODIUM HYDROGEN PHOSPHATE-2-HYDRATE
DI-SODIUM HYDROGEN PHOSPHATE CONCENTRATE I
DI-SODIUM HYDROGEN PHOSPHATE CONCENTRATE II
DI-SODIUM HYDROGEN PHOSPHATE DIHYDRATE
Disodium monohydrogen phosphate | [EINECS(EC#)]
231-448-7 | [Molecular Formula]
HNa2O4P | [MDL Number]
MFCD00003496 | [Molecular Weight]
141.96 | [MOL File]
7558-79-4.mol |
| Chemical Properties | Back Directory | [Appearance]
white granular powder | [Melting point ]
243-245 °C
| [density ]
1.064 g/mL at 20 °C
| [vapor density ]
4.9 (vs air)
| [vapor pressure ]
0Pa at 20℃ | [FEMA ]
2398 | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.5 M at 20 °C, clear, colorless
| [form ]
powder
| [color ]
White | [Odor]
odorless | [PH]
8.9-9.2 (25℃, 50g/L in water) | [pka]
(1) 2.15, (2) 6.82, (3) 12.38 (at 25℃) | [Stability:]
Stable. Incompatible with strong acids. Hygroscopic. | [Water Solubility ]
>=10 g/100 mL at 20 ºC | [Sensitive ]
Hygroscopic | [λmax]
λ: 260 nm Amax: 0.019
λ: 280 nm Amax: 0.016 | [Merck ]
14,8659 | [InChIKey]
BNIILDVGGAEEIG-UHFFFAOYSA-L | [LogP]
-2.15 | [CAS DataBase Reference]
7558-79-4(CAS DataBase Reference) | [EPA Substance Registry System]
7558-79-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3
| [RTECS ]
WC4500000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
28352200 | [Safety Profile]
Poison by intravenous route. Moderately toxic by intraperitoneal, subcutaneous, and intramuscular routes. Mildly toxic by ingestion. A skin and eye irritant. When heated to decomposition it emits toxic fumes of POx and Na2O. See also PHOSPHATES. | [Hazardous Substances Data]
7558-79-4(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Hazard Information | Back Directory | [Description]
Sodium phosphate dibasic is highly hygroscopic and water soluble. Useful in conjunction with Sodium Phosphate, Monobasic in the preparation of biological buffers. It is commonly used in biological assay buffers.
Sodium is required for nerve and muscle functioning. Sodium Phosphate Dibasic can be used as a dietary supplement and as a nutrient.
Sodium hydrogen phosphate is used in food and water treatment in conjunction with trisodium phosphate.In foods, it is used to adjust pH. In water treatment, It retards calcium scale formation. It is also found in some detergents and cleaning agents.
This product is known to be Used in many applications including the purification of antibodies. It is used as a saline laxative to treat constipation or to clean the bowel before a colonoscopy. | [Physical properties]
The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water;insoluble in alcohol.
The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C.
The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C.
The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C.
All the hydrates are soluble in water and insoluble in alcohol. | [Occurrence]
Disodium phosphate is anhydrous or contains two molecules of water of hydration | [Definition]
ChEBI: Disodium hydrogenphosphate is a sodium phosphate. | [General Description]
| [Flammability and Explosibility]
Nonflammable | [Biochem/physiol Actions]
Sodium phosphate dibasic is an important component of running buffer of denaturing gel electrophoresis. It induces glomerular calcification as well as other nephrotic syndrome in Sprague-Dawley rats. | [Purification Methods]
Crystallise the salt twice from warm water, by cooling. Dry in air, then in an oven overnight at 130o. It should be dried before use as it is slightly hygroscopic. It forms di-, hepta-and deca-hydrates. |
| Questions and Answers (Q&A) | Back Directory | [Chemical Properties]
The anhydrous compound is white crystalline powder; hygroscopic; density 1.70 g/cm3; converts to sodium pyrophosphate at 240°C; soluble in water; 874 SODIUM PHOSPHATE, DIBASIC insoluble in alcohol. The dihydrate is a crystalline powder or granular solid; density 2.066 g/cm3 at 15°C; loses water of crystallization at 92.5°C. The heptahydrate is a powdered or granular crystalline solid; density 1.679 g/cm3; loses five molecules of water at 48°C. The dodecahydrate is made up of translucent crystals or granules; density 1.524 g/cm3; readily loses five water molecules on exposure to air at ambient temperature; melts at 35°C when the salt contains all water of crystallization; loses all water at 100°C. All the hydrates are soluble in water and insoluble in alcohol.
| [Uses]
Sodium Phosphate, Dibasic is used as a laboratory reagent and a buffer in chemical analysis. Other uses are in manufacturing ceramics, detergents, and enamels; as a mordant in dyeing; for fireproofing paper and wood; for weighting and printing silk; in the treatment of boiler water; as a sequestrant in food; as a dietary supplement; in soldering enamels; and in fertilizers. It is used therapeutically as a cathartic.
| [Preparation]
Dibasic sodium phosphate is prepared by treating phosphoric acid with a slight excess of sodium carbonate. The solution is boiled to expel carbon dioxide. Upon cooling dodecahydrate crystallizes out. Heating dodecahydrate at 100°C forms the anhydrous salt.
H3PO4 + Na2CO3 → Na2HPO4 + CO2 + H2O
Dibasic sodium phosphate also is prepared by reacting dibasic calcium phosphate with sodium carbonate. The product calcium carbonate precipitates leaving dibasic sodium salt in the solution. The solution on cooling yields crystals of hydrated product.
CaHPO4 + Na2CO3 → CaCO3 + Na2HPO4
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