Tinidazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
solid
Verwenden
Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.
Antimicrobial activity
Its antibacterial and antiprotozoal activity is similar to that of metronidazole.The MIC against G. vaginalis is 0.2–2 mg/L; the hydroxy metabolite is significantly more active than that of metronidazole. H. pylori is inhibited by 0.5 mg/L. T. vaginalis and T. fetus at 2.5 mg/L and E. histolytica is inhibited by about 0.3–2.5 mg/L.
Pharmazeutische Anwendungen
A 5-nitroimidazole available for oral administration and, in some countries, for intravenous infusion.
Mechanism of action
Tinidazole has a mechanism of action that parallels that of metronidazole as well
as a similar metabolic pathway leading to hydroxylation at the 2-methyl group catalyzed by
CYP3A4. Basically, tinidazole appears to mimic the actions of metronidazole, although there are
reports that it is effective against some protozoa which are resistant to metronidazole.
Clinical Use
Anaerobic bacterial infections(prophylaxis and treatment)
Trichomoniasis
Giardiasis (single dose) Amebiasis (including amebic liver abscess)
Bacterial vaginosis
Gastric colonization with H. pylori (in combination with other agents)
Nebenwirkungen
Tinidazole is generally well tolerated. Infrequent and transient effects include nausea, vomiting, diarrhea and a metallic taste. Disulfiram-like reactions may occur and rare neurological disturbances and transient leukopenia have been described. Rash, which may be severe, urticaria and angioneurotic edema can occur.
Tinidazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
