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(1R)-(-)-10-Camphorsulfonic acid

(1R)-(-)-10-Camphorsulfonic acid Structure
(1R)-(-)-10-Camphorsulfonic acid structure
CAS No.
35963-20-3
Chemical Name:
(1R)-(-)-10-Camphorsulfonic acid
Synonyms
(-)-CSA;(1R)-(-)-CAMPHOR-10-SULFONIC ACID;((1R,4S)-7,7-DiMethyl-2-oxobicyclo[2.2.1]heptan-1-yl)Methanesulfonic acid;(-)-10-CSA;L-(-)-CAMPHORSULFONIC ACID;(-)-10-CAMPHORSULFONIC ACID;d-Camphor-10-sulphonic acid;(-)-10-Camphorsulfonic Acid;(1R)-CAMPHOR-10-SULFONIC ACID;L-10-(-)-CAMPHOR SULFONIC ACID
CBNumber:
CB0365888
Molecular Formula:
C10H16O4S
Molecular Weight:
232.3
MDL Number:
MFCD00064158
MOL File:
35963-20-3.mol
MSDS File:
SDS
Last updated:2024-04-24 17:21:45
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(1R)-(-)-10-Camphorsulfonic acid Properties

Melting point 198 °C (dec.)(lit.)
Boiling point 344.46°C (rough estimate)
alpha -22 º (c=20,H2O)
Density 1.2981 (rough estimate)
refractive index -21.5 ° (C=5, H2O)
storage temp. Store below +30°C.
solubility DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
pka 1.17±0.50(Predicted)
form Crystalline Powder
color White to slightly beige
PH 1.2-1.4 (20g/l, H2O)
optical activity [α]20/D 21°, c = 2 in H2O
Water Solubility soluble
Sensitive Hygroscopic
BRN 2809676
Stability Stable. Hygroscopic. Incompatible with strong bases, strong oxidizing agents.
InChIKey MIOPJNTWMNEORI-XVKPBYJWSA-N
CAS DataBase Reference 35963-20-3(CAS DataBase Reference)
FDA UNII Y6075I4FXE

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45-24/25-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
F  3-10
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29147090
NFPA 704
0
3 0

(1R)-(-)-10-Camphorsulfonic acid price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.40094 (1R)-(-)-Camphor-10-sulfonic acid for synthesis 35963-20-3 100g $177 2024-03-01 Buy
Sigma-Aldrich 21365 (?)-Camphor-10-sulfonic acid purum,≥98.0%(T) 35963-20-3 50g $99.5 2024-03-01 Buy
Sigma-Aldrich 21365 (?)-Camphor-10-sulfonic acid purum,≥98.0%(T) 35963-20-3 250g $344 2024-03-01 Buy
TCI Chemical C0972 (-)-10-Camphorsulfonic Acid >98.0%(T) 35963-20-3 25g $30 2024-03-01 Buy
TCI Chemical C0972 (-)-10-Camphorsulfonic Acid >98.0%(T) 35963-20-3 100g $71 2024-03-01 Buy
Product number Packaging Price Buy
8.40094 100g $177 Buy
21365 50g $99.5 Buy
21365 250g $344 Buy
C0972 25g $30 Buy
C0972 100g $71 Buy

(1R)-(-)-10-Camphorsulfonic acid Chemical Properties,Uses,Production

L-Camphorsulfonic acid

Camphor sulfonic acid includes L-camphor sulfonic acid, D-camphor sulfonic acid and racemic camphor sulfonic acid these three isomers.
It is a kind of white columnar crystals with the melting point of 193°C (decomposition). [α]D20+24° (water). It is Slightly soluble in ethanol, insoluble in ether, soluble in sodium hydroxide and sodium carbonate solution. L-camphor sulfonic acid could be produced from reaction between camphor, sulfuric acid and acetic anhydride.It has a lot of functions such as exciting the respiratory center, the vascular movement center and myocardium. Its sodium salt plays pharmaceutical role in medicine.
Camphor sulfonic acid sodium salt is a kind of white crystalline powder. It is odorless and tastes bitter and then sweet. It is easily absorb moisture and easily dissolve in the water and hot ethanol. So it should be shading confined preservation. it can Directly excite the medulla oblongata respiratory center and vascular movement center, and quicken and deepen the breath, rise the blood pressure; it also can directly excite the myocardium and strength the contraction of cardiac muscle as well as could increase the output.
It is applied the treatment of infectious disease, as well as the disease like central inhibition of poisoning caused by respiratory depression, fatigue, high fever, poisoning, heat stroke and other acute heart failure.

Uses

(1) It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Production method

Camphor sulfonic acid is obtained from camphor and sulfuric acid by irradiation.
This method involves:
1) Adding the camphor and acetic anhydride to the pot.
2) Mixing it and making it dissolved.
3) Dripping sulfuric acid after cooling. And the reaction should be maintained at 44-45 °C for 48 hours. Then cool it to 6-7 °C.
4) Crystallizing, filtrating, washing with a small amount of acetic acid crystals, and dry it to get camphor sulfonic acid.

Physical properties

(1R)-(-)-10-Camphorsulfonic acid is a kind of prismatic crystals and its melting point is 193-195 ° C (decompose). It is Insoluble in ether and slightly soluble in glacial acetic acid and ethyl acetate. And it is and moisture in wet air.

Uses

(1R)-(-)-Camphor-10-sulfonic acid, is used as a pharamaceutical intermediate and also used as a chiral derivative of Camp. It can also be used as resolving agents for chiral amines and other cations.

Uses

1R)-(-)-10-Camphorsulfonic acid is a chiral derivative of Camphor.It has the following uses:
(1)It is also used for the racemization of optical isomers.
(2) It can be applied to the resolution of intermediate or isomer in medicine.
(3) It also could play a role as organic synthesis intermediates and resolving agent.

Definition

ChEBI: The R enantiomer of camphorsulfonic acid.

General Description

(1R)-(-)-10-Camphorsulfonic acid is an HPLC derivatization reagent for UV/Vis detection. It is mainly employed for the resolution of bases.

Purification Methods

It forms prisms from AcOH or EtOAc, and is deliquescent in moist air. Store it in tightly stoppered bottles. The NH4 salt forms needles from H2O [] D ±20.5o (c 5, H2O). [Burgess & Lowry J Chem Soc 127 279 1925, Marsi et al. J Am Chem Soc [ 78 3063 1956.] The RS-acid recrystallises from AcOH. [60g of (±)-acid in 60mL of AcOH at 105o gave 40g of crystals has m 202-203o [Bartlett & Knox Org Synth 45 12 1965.] [Beilstein 11 IV 642.]

(1R)-(-)-10-Camphorsulfonic acid synthesis

137234-71-0
35963-20-3
Synthesis of (1R)-(-)-10-Camphorsulfonic acid from Voriconazole

(1R)-(-)-10-Camphorsulfonic acid Preparation Products And Raw materials

Raw materials

D-CAMPHOR Sulfuric acid

Preparation Products

(R)-(-)-3-Quinuclidinol GERANYL BUTYRATE (R)-4-Boc-Piperazine-3-carboxylic acid polyaniline composite film (R)-PIPERAZINE-2-CARBOXYLIC ACID
(R)-3-Quinuclidinol hydrochloride (1R)-(-)-10-CAMPHORSULFONIC ACID, AMMONIUM SALT

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(1R)-(-)-10-Camphorsulfonic acid Suppliers

Global( 596)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Ouhuang Engineering Materials (Hubei) Co., Ltd 		+8617702722807 admin@hbouhuang.com China 2259 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15928 58
Shanghai Bojing Chemical Co.,Ltd. 		+86-86-02137122233 +8613795318958 bj1@bj-chem.com China 298 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd
58
Hebei Mojin Biotechnology Co., Ltd 		58
airuikechemical co., ltd. 		58
Ouhuang Engineering Materials (Hubei) Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Shanghai Bojing Chemical Co.,Ltd. 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55

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View Lastest Price from (1R)-(-)-10-Camphorsulfonic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L(-)-Camphorsulfonic acid pictures 2024-04-24 L(-)-Camphorsulfonic acid
35963-20-3
 US $15.00 / kg 1kg 99.912% 10ton Ouhuang Engineering Materials (Hubei) Co., Ltd
l-10-camphorsulfonic acid pictures 2024-03-29 l-10-camphorsulfonic acid
35963-20-3
 US $0.00-0.00 / Kg 1Kg 99.9% 200tons airuikechemical co., ltd.
(1R)-(-)-10-Camphorsulfonic acid pictures 2023-11-01 (1R)-(-)-10-Camphorsulfonic acid
35963-20-3
 US $0.00-0.00 / kg 0.1kg 99.0%min 200kg Hangzhou ICH Biofarm Co., Ltd

(1R)-(-)-10-Camphorsulfonic acid Spectrum

(1R)-(-)-10-Camphorsulfonic acid(35963-20-3)1HNMR(1R)-(-)-10-Camphorsulfonic acid(35963-20-3)IR

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(-)-CAMPHOR-10-SULPHONIC ACID (-)-CAMPHOR-10-SULFONIC ACID L-(+)-CAMPHOR SULFONIC ACID L(+)-CAMPHORSULPHONIC ACID L-CAMPHORSULPHONIC ACID (1R)-(-)-CAMPHOR-10-SULPHONIC ACID (1R)-(-)-CAMPHORSULFONIC ACID (1r)-[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulphonic acid (1R)-(-)-10-CAMPHORSULFONIC ACID 2-Oxo-10-bornane-sulfonicacid 7,7-Dimethyl-2-oxobicyclo[2,2,1]heptane-1-methane-sulfonicacid Camphor-sulphonicacid Voriconazole Related CoMpound F (1R)-(-)-10-Camphosulfonic acid L - Campho 10 Sulphonic Acid (1R)-(-)-Camphor-10-sulfonic acid, 98+% CLOPIDOGREL INTERMEDIATES (1R)-(-)-CAMPHOR-10-SULPHONIC ACID 99% S-(-)-CAMPHORSULFONIC ACID (1R)-(-)-CAMPHER-10-SULFONSURE )-Camphor-10-sulfonic acid (1R)-Camphor-10-sulfonic acid L(-)-Camphorsulfonic acid (1R)-(-)-Camphor-10-sulfonic acid for synthesis (1R)-(-)-10-CaMphorsulfonic acid 98% L- caMphor sulfonic acid (L-caMphor sulfonic acid) L(-)-Camphorsulfonic acid 1R-(-)-10-Camphorsulfonic acid (-)-Camphor-10-sulfonic acid, (1R)-(-)-Camphor-10-sulfonic acid, (1R)-Camphor-10-sulfonic acid (-)-(1R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)- (1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1α-methanesulfonic acid [1R,4S,(-)]-2-Oxobornane-10-sulfonic acid [1R,4S,(-)]-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1R)-Camphor-10-sulfonic acid L(-)-Camphorsulfonic acid (-)-10-Camphorsulfonic acid ,99% ()-Camphor-10-sulfonic acid,(1R)-()-Camphor-10-sulfonic acid (1R)-()-10-Camphorsulfonic acid,()-Camphor-10-sulfonic acid, (1R)-()-Camphor-10-sulfonic acid, (1R)-Camphor-10-sulfonic acid L(-)-Camphorsulfonic L(-)-Camphorsulfonic acid,98% (1R)-(-)-CAMPHOR-10-SULPHONIC ACIDCaMphorSulfonic Acid L(-)-CaMphorsulfonic acid, 98% 5GR (R)-()-10-CaMphorsulfonic acid Voriconazole Related Compound 11 Voriconazole EP Impurity E (1R)-Isomer [(1S,4R)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid [(4R)-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid Camphor Impurity 3（(1R)-10-Camphorsulfonic Acid） (-)-CamphorsuL (-)-10-Camphorsulfonic acid, 99%, reagent grade (-)-10-Camphorsulfonic Acid > (1R)-(-)-CAMPHOR-10-SULFONIC ACID FOR SY (1R,4S)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid Camphor Sulfonic Acid sec-Butyl Ester(1R)-10-Camphorsulfonic Acid (R)-camphorsulfonicaci L-Camphor Sulfonic Acid Impurity 1R-(-)-1-Camphorsulfonic acid L-10 Camphor Sulphonic Acid pure, 99% L- (-) CAMPHOR SULPHONIC ACID Extra Pure L-10-(-)-CAMPHOR SULFONIC ACID