Dexpanthenol
- CAS No.
- 81-13-0
- Chemical Name:
- Dexpanthenol
- Synonyms
- D-PANTHENOL;Provitamin B5;D-PANTOTHENYL ALCOHOL;D-PANTOTHENOL;(R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE;Bepanthen;Pantol;Pantenyl;PROVITAMIN B;PANTHENOL, D-
- CBNumber:
- CB3169304
- Molecular Formula:
- C9H19NO4
- Molecular Weight:
- 205.25
- MDL Number:
- MFCD00065006
- MOL File:
- 81-13-0.mol
- MSDS File:
- SDS
| Melting point | 64～69℃ |
|---|---|
| alpha | 30.5 º (c=5, H2O on anh. sub) |
| Boiling point | 118-120 °C (2.7 mmHg) |
| Density | 1.20 g/mL at 20 °C (lit.) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.495-1.502 |
| Flash point | 118-120°C/0.02m |
| storage temp. | 2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly), Water (Sparingly) |
| pka | 13.03±0.20(Predicted) |
| form | Viscous Liquid or Semi Solid |
| color | Clear colorless to slightly yellow |
| PH | pH (100g/l,25℃) : 8.5～10.5 |
| optical activity | [α]20/D +30±1°, c = 5% in H2O |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,2947 |
| BRN | 1724947 |
| InChIKey | SNPLKNRPJHDVJA-ZETCQYMHSA-N |
| LogP | -1.06 at 22℃ |
| FDA 21 CFR | 582.5580; 310.545 |
| Substances Added to Food (formerly EAFUS) | D-PANTOTHENYL ALCOHOL |
| SCOGS (Select Committee on GRAS Substances) | D-Pantothenyl alcohol |
| CAS DataBase Reference | 81-13-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 1O6C93RI7Z |
| NCI Drug Dictionary | Ilopan |
| ATC code | A11HA30,D03AX03,S01XA12 |
| NIST Chemistry Reference | Dexpanthenol(81-13-0) |
| EPA Substance Registry System | (+)-Panthenol (81-13-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-48-41-37/38-20/21/22 | |||||||||
| Safety Statements | 23-24/25-45-36/37/39-26-22 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | ES4316000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29241990 | |||||||||
| Toxicity | LD50 oral in mouse: 15gm/kg | |||||||||
| NFPA 704 |
|
Dexpanthenol price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 76200 | D-Panthenol ≥98.0% (NT) | 81-13-0 | 25ml | $59.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1179504 | Dexpanthenol Pharmaceutical Secondary Standard; Certified Reference Material | 81-13-0 | 500mg | $466 | 2024-03-01 | Buy |
| TCI Chemical | P0692 | D-Panthenol >98.0%(T) | 81-13-0 | 25g | $38 | 2024-03-01 | Buy |
| TCI Chemical | P0692 | D-Panthenol >98.0%(T) | 81-13-0 | 500g | $253 | 2024-03-01 | Buy |
| Alfa Aesar | A18499 | D-Panthenol, 98+% | 81-13-0 | 100g | $55.6 | 2024-03-01 | Buy |
Dexpanthenol Chemical Properties,Uses,Production
Description
Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
References
https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol#section=Top
https://www.drugs.com/pro/dexpanthenol.html
https://de.wikipedia.org/wiki/Dexpanthenol
Chemical Properties
clear colorless to slightly yellow viscous liquid
Originator
Bepanthene,Roche,France,1951
Uses
immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic
Uses
cholinergic
Uses
Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.
Uses
D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.
Definition
ChEBI: Pantothenol is a monocarboxylic acid amide that is 3,3-dimethylbutanamide substituted by hydroxy groups at positions 2 and 4 and a 3-hydroxypropyl group at the carbomyl nitrogen. It has a role as a cholinergic drug and a provitamin. It is an amino alcohol and a monocarboxylic acid amide.
Manufacturing Process
130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C.
brand name
D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).
Therapeutic Function
Gastrointestinal drug
General Description
Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flammability and Explosibility
Non flammable
Biochem/physiol Actions
D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.
Contact allergens
Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.
Safety Profile
Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.
Veterinary Drugs and Treatments
Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications.
Purification Methods
Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]
Dexpanthenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | sales@blitchem.com | China | 291 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 476 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 893 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yime New Material Technology Co., Ltd. | +86-66697723 +86-17703311139 | admin@china-yime.com | China | 563 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 338 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Shandong Juchuang Chemical Co., LTD | +86-18885615001 +86-18885615001 | admin@juchuangchem.com | China | 387 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 747 | 58 |
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- Jul 29，2022
View Lastest Price from Dexpanthenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | D-Panthenol
81-13-0
|
US $0.00-0.00 / kg | 0.10000000149011612kg | ≥99% | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | |
 |
2024-04-26 | Dexpanthenol
81-13-0
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-26 | Dexpanthenol
81-13-0
|
US $0.00 / Kg/Drum | 1KG | 99% | 500mt/year | Jinan Finer Chemical Co., Ltd |
-
- D-Panthenol
81-13-0
- US $0.00-0.00 / kg
- ≥99%
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
-
- Dexpanthenol
81-13-0
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Dexpanthenol
81-13-0
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd