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Forodesine

Forodesine structure

CAS No.: 209799-67-7

Chemical Name:: Forodesine

Synonyms: Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

CBNumber:: CB41120376

Molecular Formula:: C11H14N4O4

Molecular Weight:: 266.25

MDL Number:: MFCD09837827

MOL File:: 209799-67-7.mol

Last updated:2023-06-08 09:03:02

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Forodesine Properties

Boiling point	613.5±65.0 °C(Predicted)
Density	2.01
storage temp.	Hygroscopic, Refrigerator, under inert atmosphere
solubility	PBS (pH 7.2): 5 mg/ml
form	A crystalline solid
pka	13.88±0.70(Predicted)
FDA UNII	426X066ELK

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

NFPA 704

	0
2		0

Forodesine price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	30475	Forodesine	209799-67-7	1mg	$36	2023-06-20	Buy
Cayman Chemical	30475	Forodesine	209799-67-7	25mg	$308	2023-06-20	Buy
Cayman Chemical	30475	Forodesine	209799-67-7	5mg	$159	2023-06-20	Buy
Cayman Chemical	30475	Forodesine	209799-67-7	10mg	$194	2023-06-20	Buy
TRC	F754540	Fodosine	209799-67-7	1mg	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
30475	1mg	$36	Buy
30475	25mg	$308	Buy
30475	5mg	$159	Buy
30475	10mg	$194	Buy
F754540	1mg	$55	Buy

Forodesine Chemical Properties,Uses,Production

Description

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC₅₀s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC₅₀s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Uses

Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Definition

ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.

Forodesine Preparation Products And Raw materials

Raw materials

Preparation Products

Forodesine Suppliers

Global( 46)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9335	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	10026	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1494	55

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Hefei Hirisun Pharmatech Co., Ltd	58
NewCan Biotech Limited	58
Alfa Chemistry	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
NCE Biomedical Co.,Ltd.	55

View Lastest Price from Forodesine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-13	Forodesine 209799-67-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2021-07-09	Forodesine 209799-67-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Forodesine
209799-67-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Forodesine
209799-67-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

209799-67-7(Forodesine)Related Search:

Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Povidone iodine

1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Forodesine METHYL-2-PYRROLIDONE

1of2

4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro- Forodesine 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Fodosine Immucillin-H (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H FORODESINE FODOSINE 4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro- BCX-1777 freebase Isopamphos (1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 209799-67-7