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Amlodipine Besylate

Description References

CAS No. 111470-99-6
Chemical Name: Amlodipine Besylate
Synonyms: Amlor;Amcard;Lowrac;Norvas;Vazkor;NORVASC;Amdepin;Amdipin;Amlodin;Amlopin
CBNumber: CB4127875
Molecular Formula: C26H31ClN2O8S
Formula Weight: 567.05
MOL File: 111470-99-6.mol
Amlodipine Besylate Property
Melting point : 199-201°C
storage temp. : Store at RT
solubility : DMSO: 20 mg/mL
form : solid
color : white
Water Solubility : Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
CAS DataBase Reference: 111470-99-6(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn
Risk Statements : 22-36/37/38-20/21/22
Safety Statements : 26-36
WGK Germany : 3
RTECS : US7967700
Hazardous Substances Data: 111470-99-6(Hazardous Substances Data)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Amlodipine Besylate Chemical Properties,Usage,Production

Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.
Chemical Properties
White Crystalline Solid
A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
Angiotensin II inhibitor prodrug, antihypertensive
Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
ChEBI: The benzenesulfonate salt of amlodipine.
Biological Activity
L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
Amlodipine Besylate Preparation Products And Raw materials
Raw materials
Preparation Products
Amlodipine Besylate Suppliers      Global( 273)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 CHINA 3230 55
Boen pharm 86 512-62572107 62962707
86 512-62922078 China 803 58
Shenzhen Simeiquan Biotechnology Co. Ltd 18126413629 0755-23311925 QQ2355327053
0755-23311925 China 4926 58
Guangzhou Kafen Biotech Co.,Ltd 020-31121484 18027468163 QQ:2355327168
020-31121510 China 4346 55
Taian Jiaye Biotechnology Co.Ltd --
-- China 3190 55
Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876
027-59721024 China 1860 58
Shanghai Boyle Chemical Co., Ltd. 86-21-50180596
86-21-57758967 China 2815 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96831 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) China 40403 62
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3589 66
111470-99-6(Amlodipine Besylate)Related Search:
Tofacitinib citrate ABT-199 Felodipine Fingolimod hydrochloride BIRB 796 (Doramapimod) Z-VAD-FMK Valsartan Telmisartan Enalapril Amlodipine (S)-Amlodipine Amlodipine mesylate Amlodipine Besylate Pyridine Benzenesulfonic acid AMLODIPINE BESILATE IMP.D (EP): 3-ETHYL-5-METHYL 2-[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYLPYRIDINE-3,5-DICARBOXYLATE
2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate 111470-99-6 Cell Signaling and Neuroscience Calcium Channel Modulators Cell Biology BioChemical AMLODIPINE BENZENESULFONATE AMLODIPINE BESILATE AMLODIPINE BESYLATE NORVASC Ion Channels Inhibitors and Activators Voltage-gated Ion Channels 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate AMLODIPINE BESILATE MM(CRM STANDARD) AMLODIPINE BESYLATE EPY(CRM STANDARD) C20H25ClN2O5C6H6O3S 11470-99-6 2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE) (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate Amcard Amdepin Amdipin Amlodin Amlopin Amlor Amlosyn Antacal Benzenesulfonic acid, compd. with 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate (1:1) Calchek Lowrac Monopina Norvas Norvask Tensivask UK 48340-26 C26H31ClN2O8S Active Pharmaceutical Ingredients 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate Ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chloropohenyl)-1,4-dihydro-5-(methoxycarbonyl)-6-methylpyridine-3-carboxylate benzenesulphonate Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals Amlodipine 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl·benzenesulfonic acid C20H25ClN2O5C6H5SO3H Aromatics Dihydropyridine Heterocycles Amlodipine Besylate (350 mg) Vazkor 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate BENICAR
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