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Amlodipine besilate

Description References

CAS No.111470-99-6
Chemical Name:Amlodipine besilate
Synonyms:Amlor;Amcard;Lowrac;Norvas;Vazkor;NORVASC;Amdepin;Amdipin;Amlodin;Amlopin
CBNumber:CB4127875
Molecular Formula:C26H31ClN2O8S
Formula Weight:567.05
MOL File:111470-99-6.mol
Amlodipine besilate Property
Melting point : 199-201°C
storage temp. : Store at RT
solubility : DMSO: 20 mg/mL
form : solid
color : white
Water Solubility : Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
CAS DataBase Reference: 111470-99-6(CAS DataBase Reference)
Safety
Hazard Codes : Xn
Risk Statements : 22-36/37/38-20/21/22
Safety Statements : 26-36
WGK Germany : 3
RTECS : US7967700
Hazardous Substances Data: 111470-99-6(Hazardous Substances Data)

Amlodipine besilate Chemical Properties,Usage,Production

Description
Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers. One of the amlodipine product on the market is Norvasc®.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.
References
[1] http://www.webmd.com/drugs/2/drug-5891/amlodipine-oral/details
[2] https://www.drugs.com/amlodipine.html
[3] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4b30c56-7403-4f69-9a8e-3d82a37e8bc5#section-1
Chemical Properties
White Crystalline Solid
Uses
A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
Uses
Angiotensin II inhibitor prodrug, antihypertensive
Uses
Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Definition
ChEBI: The benzenesulfonate salt of amlodipine.
Biological Activity
L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
Amlodipine besilate Preparation Products And Raw materials
Raw materials
Preparation Products
Amlodipine besilate Suppliers      Global( 267)Suppliers     
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Shenzhen Sendi Biotechnology Co.Ltd.
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Boen pharm 86 512-62572107 62962707
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Shenzhen Simeiquan Biotechnology Co. Ltd 18126413629 0755-23311925 QQ2355327053
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Guangzhou Kafen Biotech Co.,Ltd 020-31121484 18027468163 QQ:2355327168
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Wuhan HongxinKang Fine Chemical Co., Ltd. 18672345876
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Shanghai Boyle Chemical Co., Ltd. 86-21-50180596
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INTATRADE GmbH +49 3493/605464
+49 3493/605470sales@intatrade.de Germany 3589 66
 
111470-99-6(Amlodipine besilate)Related Search:
Tofacitinib citrate ABT-199 Felodipine Fingolimod hydrochloride BIRB 796 (Doramapimod) Z-VAD-FMK 3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid Telmisartan Enalapril Amlodipine (S)-Amlodipine Amlodipine mesylate Amlodipine besilate Pyridine Benzenesulfonic acid AMLODIPINE BESILATE IMP.D (EP): 3-ETHYL-5-METHYL 2-[(2-AMINOETHOXY)METHYL]-4-(2-CHLOROPHENYL)-6-METHYLPYRIDINE-3,5-DICARBOXYLATE
2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate 111470-99-6 Cell Signaling and Neuroscience Calcium Channel Modulators Cell Biology BioChemical AMLODIPINE BENZENESULFONATE AMLODIPINE BESILATE AMLODIPINE BESYLATE NORVASC Ion Channels Inhibitors and Activators Voltage-gated Ion Channels 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1, 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate AMLODIPINE BESILATE MM(CRM STANDARD) AMLODIPINE BESYLATE EPY(CRM STANDARD) C20H25ClN2O5C6H6O3S 11470-99-6 2-[(2-aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE) (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate Amcard Amdepin Amdipin Amlodin Amlopin Amlor Amlosyn Antacal Benzenesulfonic acid, compd. with 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate (1:1) Calchek Lowrac Monopina Norvas Norvask Tensivask UK 48340-26 C26H31ClN2O8S Active Pharmaceutical Ingredients 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate Ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chloropohenyl)-1,4-dihydro-5-(methoxycarbonyl)-6-methylpyridine-3-carboxylate benzenesulphonate Dihydropyridine Class Chemicals Intermediates & Fine Chemicals Pharmaceuticals Amlodipine 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl·benzenesulfonic acid C20H25ClN2O5C6H5SO3H Aromatics Dihydropyridine Heterocycles Amlodipine Besylate (350 mg) Vazkor 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate BENICAR
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