Manidipine hydrochloride
- CAS No.
- 89226-75-5
- Chemical Name:
- Manidipine hydrochloride
- Synonyms
- Calslot;CV 4093;CV-4093(2HCl);Manidipine DiHCl;cv-4093dihydrochlorde;Manidipine DihydrochL;Hydrochloric Manidipine;franidipinehydrochloride;MANIDIPINE HYDROCHLORIDE;Manidipine Dihydrochlorid
- CBNumber:
- CB5715288
- Molecular Formula:
- C35H40Cl2N4O6
- Molecular Weight:
- 683.62
- MDL Number:
- MFCD00896434
- MOL File:
- 89226-75-5.mol
Melting point | 157-163°; mp 174-180°; mp 167-170° |
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storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Soluble in DMSO (>25 mg/ml) |
form | solid |
color | White |
Water Solubility | Soluble in DMSO. Slightly soluble in water and ethanol /n |
Merck | 14,5743 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
CAS DataBase Reference | 89226-75-5(CAS DataBase Reference) |
FDA UNII | ZL507UZ6QL |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Symbol(GHS) | GHS06 |
Signal word | Danger |
Signal word | Danger |
Hazard statements | H301-H336 |
Hazard statements | H301-H336 |
Precautionary statements | P261-P264-P301+P310+P330-P304+P340+P312-P403+P233-P501 |
Precautionary statements | P261-P264-P301+P310+P330-P304+P340+P312-P403+P233-P501 |
RIDADR | UN 2811 6.1/PG III |
RTECS | US7975300 |
HS Code | 2933.59.8000 |
HazardClass | 6.1 |
PackingGroup | III |
Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 387, 340, 222, 199 s.c.; 62.2, 68.0, 66.5, 48.8 i.p.; 190, 171, 247, 156 orally (Chiba) |
Manidipine hydrochloride price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2425 | Manidipine hydrochloride ≥98% (HPLC) | 89226-75-5 | 5mg | $53.28 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2425 | Manidipine hydrochloride ≥98% (HPLC) | 89226-75-5 | 25mg | $359 | 2024-03-01 | Buy |
TCI Chemical | M2225 | Manidipine Dihydrochloride >98.0%(HPLC)(T) | 89226-75-5 | 1g | $168 | 2024-03-01 | Buy |
TCI Chemical | M2225 | Manidipine Dihydrochloride >98.0%(HPLC)(T) | 89226-75-5 | 5g | $577 | 2023-06-20 | Buy |
Alfa Aesar | J60496 | Manidipine dihydrochloride | 89226-75-5 | 25mg | $99.65 | 2024-03-01 | Buy |
Manidipine hydrochloride Chemical Properties,Uses,Production
Description
Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Uses
aldosterone antagonist
Uses
Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.
Definition
ChEBI: Manidipine dihydrochloride is a diarylmethane.
References
Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130
Manidipine hydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xuchang Hengsheng Pharmaceutical Co., Ltd | +86-03745692999 +86-13569491380 | xccxn@xchsyy.com | China | 15 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 288 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
View Lastest Price from Manidipine hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | Manidipine hydrochloride
89226-75-5
|
US $1.00 / g | 50g | 98.0% ~ 101.5%,USP42 | 5kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-08-07 | Manidipine Hydrochloride
89226-75-5
|
US $0.00 / Kg | 1Kg | ≥99.0% | 10 Tons | Xuchang Hengsheng Pharmaceutical Co., Ltd | ||
2024-04-15 | Manidipine hydrochloride
89226-75-5
|
US $1.00 / mg | 1mg | 0.99 | 5ton/month | ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD |
- Manidipine hydrochloride
89226-75-5
- US $1.00 / g
- 98.0% ~ 101.5%,USP42
- WUHAN FORTUNA CHEMICAL CO., LTD
- Manidipine Hydrochloride
89226-75-5
- US $0.00 / Kg
- ≥99.0%
- Xuchang Hengsheng Pharmaceutical Co., Ltd
- Manidipine hydrochloride
89226-75-5
- US $1.00 / mg
- 0.99
- ANHUI SHENGZHIKAI BIOTECHNOLOGY CO.,LTD