3-Chlorobenzoic acid
- CAS No.
- 535-80-8
- Chemical Name:
- 3-Chlorobenzoic acid
- Synonyms
- MCBA;M-CHLOROBENZOIC ACID;3-chlorobenzoic;3-Chlorbenzoesαure;3-Chlorobenzoi;m-Chlorobenzoic;3-CHLOROBENZOATE;AKOS BBS-00003733;m-Chlorbenzoesαure;m-Chlorbenzoesαure
- CBNumber:
- CB7203275
- Molecular Formula:
- C7H5ClO2
- Molecular Weight:
- 156.57
- MDL Number:
- MFCD00002491
- MOL File:
- 535-80-8.mol
- MSDS File:
- SDS
Melting point | 153-157 °C (lit.) |
---|---|
Boiling point | 274-276°C |
Density | 1.496 |
refractive index | 1.5812 (estimate) |
Flash point | 150 °C |
storage temp. | Store below +30°C. |
solubility | 0.45g/l |
pka | 3.82(at 25℃) |
form | Crystalline Powder |
color | White to beige |
Water Solubility | <0.1 g/100 mL at 19.5 ºC |
Merck | 14,2123 |
BRN | 907218 |
Stability | Skin, eye and respiratory irritant. |
CAS DataBase Reference | 535-80-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 02UOJ7064K |
NIST Chemistry Reference | Benzoic acid, 3-chloro-(535-80-8) |
EPA Substance Registry System | m-Chlorobenzoic acid (535-80-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DG4975990 | |||||||||
Autoignition Temperature | >500 °C | |||||||||
TSCA | Yes | |||||||||
HS Code | 29163900 | |||||||||
NFPA 704 |
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3-Chlorobenzoic acid price More Price(42)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C24604 | 3-Chlorobenzoic acid ReagentPlus , ≥99% | 535-80-8 | 25g | $41.6 | 2024-03-01 | Buy |
Sigma-Aldrich | NIST2144 | m-Chlorobenzoic acid NIST? SRM? 2144 | 535-80-8 | 2g | $731 | 2024-03-01 | Buy |
Sigma-Aldrich | 1112299 | 3-Chlorobenzoic acid United States Pharmacopeia (USP) Reference Standard | 535-80-8 | 25mg | $1380 | 2024-03-01 | Buy |
TCI Chemical | C0132 | 3-Chlorobenzoic Acid >99.0%(GC)(T) | 535-80-8 | 25g | $30 | 2024-03-01 | Buy |
TCI Chemical | C0132 | 3-Chlorobenzoic Acid >99.0%(GC)(T) | 535-80-8 | 500g | $300 | 2024-03-01 | Buy |
3-Chlorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
A Pseudomonas species which utilized 3-chlorobenzoic acid as a carbon source converted this compound to 3-hydroxybenzoic and 2, 5-dihydroxybenzoic acids. A methanogenic consortium able to use 3-chlorobenzoic acid as its sole energy and carbon source was enriched from anaerobic sewage sludge. A Pseudomonas putida strain 87 capable of assimilating 3-chlorobenzoic acid as a sole source of carbon and energy (3Cba+) was isolated. coupling of 3-chlorobenzoic acid with phenylboronic acid proceeds at room temperature using 0.5 % Pd and at 100°C using 0.1 % Pd to provide the coupled product in 97 % yeild.
Uses
3-Chlorobenzoic acid is a fundamental chemical building block commonly used in organic synthesis of more complex structures. A benzoic acid analogue that showed antifungal activity against strains of Aspergillus flavus, Aspergillus fumigatus and Aspergillus terreus, causative agents of human aspergillosis, in in vitro bioassays.
Definition
ChEBI: 3-chlorobenzoic acid is a monochlorobenzoic acid carrying a chloro substituent at position 3. It has a role as a drug metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 3-chlorobenzoate.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 5755, 1954 DOI: 10.1021/ja01651a039
Tetrahedron Letters, 25, p. 783, 1984
General Description
Crystals or fluffy white powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
3-Chlorobenzoic acid is incompatible with strong oxidizing agents. The reactivity of the chlorine atom of 3- chlorobenzoic acid is sluggish compared with the other isomers. Decarboxylation at higher temperatures is insignificant, and it resists oxidation. 3-Chlorobenzoic acid is made by the oxidation of 3-chlorotoluene or by the hydrolysis of 3-chlorobenzoyl chloride, which is derived from benzoyl chloride. 3-Chlorobenzoic acid is used for making diphenyl ether type herbicides.
Fire Hazard
Flash point data for 3-Chlorobenzoic acid are not available; however, 3-Chlorobenzoic acid is probably combustible.
Purification Methods
Crystallise the acid successively from glacial acetic acid, aqueous EtOH and pet ether (b 60-80o). It also recrystallises from *C6H6 or Et2O/hexane, and sublimes at 55o in a vacuum. [Anal Chem 26 726 1954] The methyl ester has m 21o, b 231o/760mm. The S-benzylisothiouronium salt has m 164-165o (from EtOH) [Friediger & Pedersen Acta Chem Scand 9 1425 1955, Samuel J Chem Soc 1318 1960]. [Beilstein 9 IV 969.]
3-Chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Junwee Chemical co., Ltd. | +86-571-85808636 +86-13958122542 | sales@junweechem.com | China | 821 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21666 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 801 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2966 | 58 |
View Lastest Price from 3-Chlorobenzoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-25 | 3-Chlorobenzoic acid
535-80-8
|
US $20.00 / KG | 1KG | 98% | 200tons/ year | Speranza Chemical Co., Ltd. | ||
2024-09-23 | 3-Chlorobenzoic Acid
535-80-8
|
US $10.00 / kg | 1kg | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-18 | 3-Chlorobenzoic acid
535-80-8
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
- 3-Chlorobenzoic acid
535-80-8
- US $20.00 / KG
- 98%
- Speranza Chemical Co., Ltd.
- 3-Chlorobenzoic Acid
535-80-8
- US $10.00 / kg
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
- 3-Chlorobenzoic acid
535-80-8
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD