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Overview Chemical property Purification and dehydration method Industrial preparation methods Uses Detriment Distinguishing test Content analysis Toxicity Uses Preparation methods category Hazards & Safety Information

CAS No.75-09-2
Chemical Name:Dichloromethane
Synonyms:F30;r30;R 30;HCC30;CH2Cl2;Freon30;Nevolin;Driverit;Freon 30;Metaclen
Molecular Formula:CH2Cl2
Formula Weight:84.93
MOL File:75-09-2.mol
Dichloromethane Property
Melting point : -97 °C
Boiling point : 39.8-40 °C mm Hg(lit.)
density : 1.325 g/mL at 25 °C(lit.)
vapor density : 2.9 (vs air)
vapor pressure : 24.45 psi ( 55 °C)
refractive index : n20/D 1.424(lit.)
Fp : 39-40°C
storage temp. : Store at RT.
solubility : Miscible in ethyl acetate, alcohol, hexanes, methanol, diethyl ether, n-octanol, acetone benzene, carbon tetrachloride, diethyl ether and chloroform.
Water Solubility : 20 g/L (20 ºC)
Merck : 14,6063
BRN : 1730800
CAS DataBase Reference: 75-09-2(CAS DataBase Reference)
NIST Chemistry Reference: Methylene chloride(75-09-2)
EPA Substance Registry System: Methane, dichloro-(75-09-2)
Hazard Codes : Xn,T,F,N,C
Risk Statements : 40-39/23/24/25-23/24/25-11-67-36/37/38-68/20/21/22-20/21/22-50-37-34
Safety Statements : 23-24/25-36/37-45-16-7-26-61-36/37/39
RIDADR : UN 1593 6.1/PG 3
WGK Germany : 2
RTECS : PA8050000
F : 3-10
Hazard Note : Harmful
TSCA : Yes
HazardClass : 6.1
PackingGroup : III
Hazardous Substances Data: 75-09-2(Hazardous Substances Data)

Dichloromethane Chemical Properties,Usage,Production

Dichloromethane (CH2Cl2) is compound after the two hydrogen atoms in the methane molecules were replaced by chlorine. It is a colorless, transparent, volatile liquid heavier than water, with sweet smell similar to ether. It does not burn, but will form an explosive mixture with oxygen of high concentration. Dichloromethane is slightly soluble in water, miscible with most of common organic solvents, also miscible in any proportion with chlorine-containing solvents, ether, ethanol and N, N-dimethyl formamide. Dichloromethane at room temperature is insoluble in liquid ammonia, but can be quickly dissolved in phenol, aldehyde, ketone, acetic acid, triethyl phosphate, formamide, cyclohexylamine, ethyl acetoacetate. It’s relative density is 1.3266 (20/4 ° C), melting point-95.1 ° C, boiling point 40 ° C. as a non-flammable low boiling point solvent, it is commonly used to replace the flammable petroleum ether, diethyl ether, etc., and can be used as dental anesthetics, refrigerants and fire extinguishing agent. Spontaneous ignition at 640 ° C. Viscosity (20 ° C) 0.43 mPa • s. Refractive index nD (20 ° C) 1.4244. Its critical temperature is 237 ° C, the critical pressure 6.0795MPa. It generates HCl and trace amounts of phosgene after pyrolysis. It generates formaldehyde and HCl after long-term heating with water. CHCl3 and CCl4 can be obtained after further chlorination.
Pure dichloromethane has no flash point. Mixture contains an equal volume of dichloromethane and solvent mixture of gasoline, solvent naphtha or toluene is not flammable. However, when dichloromethane is mixed with acetone or methanol in a 10: 1 ratio, the mixture has a flash point, the vapor of which and air can form an explosive mixture with an explosion limit of 6.2% to 15.0% (volume). Dichloromethane is the least toxic methane chlorides, with only 0.11% toxicity of carbon tetrachloride. If dichloromethane is directly splashed into the eyes, it will cause pain and corrosion. Methylene chloride vapor has anesthetic effect. On the risk of severe poisoning, people should be immediately disengaged and moved to fresh air so that some symptoms of poisoning will be relieved or disappeared and will not cause lasting damage.
Chemical property
colorless, transparent, volatile liquid with pungent smell similar to ether. Soluble in water of about 50 times the volume,soluble in phenol, aldehyde, ketone, acetic acid, triethyl phosphate, ethyl acetoacetate, cyclohexylamine. Miscibile with other chlorinated hydrocarbon, solvent ethanol, ethyl ether and N, N-dimethyl formamide
Purification and dehydration method
Dichloromethane is safer than chloroform. So it is often used instead of chloroform as the extractant Heavier than water. Ordinary dichloromethane generally can be used directly as extractant. If purification is needed, it can be washed with 5% sodium carbonate solution, and then washed with water, and then dried with anhydrous calcium chloride, distillated to collect 40~41℃ distillate and stored in a brown bottle.
Industrial preparation methods
1.  Natural Gas Chlorination. First, natural gas reacts with chlorine gas. After the hydrochloric acid, the byproduct, is absorbed by water, the residual hydrogen chloride is removed by alkali solution. Then the product is dried, compressed, condensed and distilled to obtain finished product. Materials, chlorine gas 100% 4000, natural gas under standard condition, with methane content of 97% 1000m3/t, caustic soda liquid 100% 274.
2.  Chloromethane chlorination. Chlorinemethane and chlorine react in the light of 4000kW, generating dichloromethane, which after the alkaline wash, compression, condensation, drying and distillation becomes the finished product. The main by-product is trichloromethane. Materials, chlorine methane ≥98% 746, liquid chlorine ≥99.5% 854, caustic soda 30% 221.
In industry dichloromethane is generally synthesized by chlorination of methane. Methane chlorination produces a mixture of four kinds of methyl chlorides. However, since the disparity of their boiling points is relatively large, they can be conveniently separated and purified by conventional fractionation techniques.
The most important use of dichloromethane is solvent. Dichloromethane has a strong solubility, low boiling point and relatively the lowest toxicity and relatively the best reaction inertia, making it the most used organic solvent in the organic synthesis, with almost the same significance of water in inorganic chemistry. It is largely used in the manufacture of safe film, polycarbonate, the rest used as paint solvents, metal degreasing agent, gas aerosol spray, polyurethane foam, mold release agent, paint remover.
it is also used as the reaction medium in the pharmaceutical industry for the preparation of ampicillin, ampicillin and cephalosporin.
Dichloromethane is inert because of the stereoscopic electron effect, and usually does not participate in the chemical reaction. But under certain conditions it can also participate in the reaction. Explosion accident occurred in industry because of the generation of diazomethane methane when residual dichloromethane and sodium azide reacted in N, N-dimethyl formamide.
Dichloromethane is mainly used in film production and medicine in China. Film production accounts for 50% of the total consumption, medicine accounts for 20%, the cleaning agent and chemical industry accounts for 20%, and others accounts for 10%.
Health hazards: This product has anesthetic effects, mainly damages the central nervous system and respiratory system. The main route of human exposure is inhalation. It has been determined that methylene chloride is present in high concentrations in indoor production environments when dichloromethane is used as a paint remover. The dose the exposure to general population through the surrounding air, drinking water and food contact is much smaller. It is estimated that about 80% of the world production of methylene chloride is ultimately released into the atmosphere. But the photolysis rate of the compound is so fast that it is impossible to accumulate in the atmosphere. The initial degradation products are phosgene and carbon monoxide, which are then converted into carbon dioxide and hydrochloric acid. When dichloromethane is present in surface water, much of it will evaporate. In the presence of oxygen, it is easy for biodegradation, and thus bioaccumulation of it seems unlikely. But its behavior in the soil is yet to be determined.
toxicity: its oral toxicity is moderate
acute toxicity:LD50 1600~2000mg/kg(rat P.O. acute toxicity);LC50  56.2g/m3,8 hours(inhalation toxicity in mice);mice inhaling 67.4g/m3×67min,dead;human oral 20~50ml,mild intoxicated;human oral 100~150ml,dead;human inhaling 2.9~4.0g/m3×20min, dizzy.
hazardous characteristics:flammable in the case of naked flame or high fever. Its thermal decomposition can emit toxic phosgene. In the case of high fever, the increased pressure within the container may bring about cracking and explosion
Combustion (decomposition) products: carbon monoxide, carbon dioxide, hydrogen chloride, phosgene.
Distinguishing test
Slightly soluble in water, miscible in ethanol and ether
Determination through OT-42 method。
refractive index nD201.423~1.425
density ratio; 1.323~1.327
Content analysis
Dichloromethane can be separated by dibutyl phthalate (DBP), then detected by GC with TCD, and quantified by comparison with standard dichloromethane.
Reagents: carrier gas, helium (> 99.5%); carrier for white diatomaceous earth 6201 (40-60 mesh) or equivalent; stationary phase, DBP (in ether); standard dichloromethane, chromatographically pure dichloromethane;
Instruments: a gas chromatograph with TCD, a column, a 3 m x 3 to 4 mm (inner diameter) stainless steel column.
Conditions: fixed phase, 20%:DBP/6021 gasification temperature, 100℃, detection temperature 100℃; carrier gas flow rate, 70ml/min, column temperature of 70 ℃; TCD bridge current, 200mA ~; injection volume, <20μL; temperature. retention time (R) of other chlorinated solvents related to dichloromethane: methyl chloride 0.15; monochloroethane 0.34; 1,1-dichloroethylene 0.59; monochloropropylene, 0.85; carbon tetrachloride 1.86; chloroform 2.47.
ADI gives no specific stipulation (the residual amount of dichloromethane in the products should be minimized as long as the production demand is meet;FAO/WHO。1998)。
(1) Used as a non-flammable low-boiling point solvent for the production of cellulose acetate film, aerosols and antibiotics, vitamin, also as the extraction agent or metal cleaning agent
(2) Dichloromethane is the raw material of bactericide myclobutanil and myclobutanil, and also a good solvent
(3) Widely used as solvent in cellulose acetate film, cellulose triacetate spinning, oil dewaxing and  the production of aerosols and antibiotics, vitamins, steroids in the production of, and metal surface paint layer degreasing and stripping agent. In addition, it is also used in the refrigeration in cereal fumigation and low pressure refrigerators and air conditioners. As an auxiliary foamer in the production of polyether urethane polyfoam and extruded polysulfone polyfoam.
(4) Extractant. Extractant for extraction of caffeine from coffee beans, extraction solvent for hops, spices oil resin, pigment diluent.
(5) Solvent in organic synthesis
(6) Solvent in the resin and plastics industry. Widely used in medicine, plastics and film industries.
(7) Solvent of cellulose acetate, extraction agent of fat and oil, a substitute for ether and petroleum ether.
Preparation methods
(1) chlorination of chloromethane followed by distillation
(2) methane chlorination and methanol chlorination are mainly adopted. 1. Methane chlorination-the thermal chlorination of the mixture of methane, chlorine and recycled gas at 380-400℃ in the reactor. 2. Methanol chlorination: NIPPON SODA CO., LTD of Japan uses methanol, chlorine as raw materials to produce dichloromethane. Light chlorination or thermal chlorination of chloromethane is also adopted.
(3) It can be prepared by the further chlorination of chloromethane, the by-product of agrochemical production. Chlorination can be light chlorination or thermal chlorination, thermal chlorination reaction requires a temperature of 400 ℃. Light chlorination is commonly used for the difficulties in thermal chlorination.
Reaction equation: CH3Cl+Cl2→CH2Cl2+HCl
Hazards & Safety Information
toxicity grade:WHO Class II
acute toxicity:acute peroral LD50 in rats 1600 mg/kg; mouse intraperitoneal LD50: 437 mg/kg
Physiological stimulation:skin-rabbit 810  mg/24hours Severe; eyes-rabbit 500 mg/24hours Mild
Explosive hazard characteristics:Explosive when mixed with air or oxygen
Combustible hazard characteristics:It releases phosgene when heated. Its vapor  is non-flammable
transportation and storing characteristics:In ventilated dry storeroom at low temperature, kept apart from oxidizing agent and nitric acid
extinguishant: Foam extinguisher, carbon dioxide, sprayed water, yellow sand.
professional standard: TWA 350 mg/m3;STEL 879 mg/m3.
Chemical Properties
Colorless liquid
Meets ACS specifications
Suitable for HPLC, spectrophotometry, environmental testing
General Description
A colorless liquid with a sweet, penetrating, ether-like odor. Noncombustible by if exposed to high temperatures may emit toxic chloride fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover.
Air & Water Reactions
Somewhat water soluble. Subject to slow hydrolysis which is accelerated by light.
Reactivity Profile
Dichloromethane reacts vigorously with active metals such as lithium, sodium and potassium, and with strong bases such as potassium tert-butoxide. Dichloromethane is incompatible with strong oxidizers, strong caustics and chemically active metals such as aluminum or magnesium powders. The liquid will attack some forms of plastic, rubber and coatings. Dichloromethane reacts with sodium-potassium alloy, (potassium hydrogen + N-methyl-N-nitrosurea), nitrogen tetraoxide and liquid oxygen. Dichloromethane also reacts with titanium. On contact with water Dichloromethane corrodes iron, some stainless steels, copper and nickel. Dichloromethane is incompatible with alkali metals. Dichloromethane is incompatible with amines, zinc and alloys of aluminum, magnesium and zinc. Dichloromethane is liable to explode when mixed with dinitrogen pentaoxide or nitric acid. Mixtures of Dichloromethane in air with methanol vapor are flammable.
Health Hazard
INHALATION: anesthetic effects, nausea and drunkenness. CONTACT WITH SKIN AND EYES: skin irritation, irritation of eyes and nose.
Fire Hazard
Special Hazards of Combustion Products: Dissociation products generated in a fire may be irritating or toxic.
Dichloromethane Preparation Products And Raw materials
Raw materials
Chlorine Methanol METHANE
Preparation Products
DI-2-PYRIDYL THIONOCARBONATE (4-IODOPHENYL)ACETONE 3-Bromophenyl isocyanate BENZOYL ISOCYANATE 2-Amino-4,6-bis(difluoromethoxy)pyrimidine 4,5-dimethyl-1,3,2-dioxathiolane 2-oxide DIMETHYL PIMELATE Adriamycin BIS(TRIMETHYLSILYL)PEROXIDE (1,1-DIMETHYL-PROPYL)-HYDRAZINE TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE 3,5-DIBROMO-1H-1,2,4-TRIAZOLE (6R-(6alpha,7))-((Amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-ISOCHROMANONE N,N'-Diphenylurea 4-Methylbenzyl isocyanate Benzyl 2-chloroacetate 2,5-DICHLORO-P-XYLENE DIBUTYLBORON TRIFLUOROMETHANESULFONATE 2-Amino-2,3-dimethylbutyramide 4-Bromothiophene-2-carboxaldehyde Tiotropium bromide 4-Biphenylcarbonyl chloride 2-Naphthoyl chloride metaclazepam 2-(2-Butoxyethoxy)ethyl acetate 1-Adamantanecarbonyl chloride 4-DIMETHYLAMINOBENZOYL CHLORIDE 2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL ISOCYANATE dimethyl hexadecyl ammoium butayl sulfate 3-METHOXYPHENYLACETYL CHLORIDE TERT-BUTYL ISOCYANIDE Cyclopentene oxide Bis(acetonitrile)dichloropalladium(II) 2-Bromo-5-nitro-4-picoline Mitomycin C 1-Naphthoyl chloride PYRROLIDINE-1-SULFONYL CHLORIDE (S)-(+)-Methyl glycidyl ether Benzoylferrocene
Dichloromethane Suppliers      Global( 326)Suppliers     
Huainan Kedi Chemical Factory 0554-21066690554-2666215sales1@kedichem.comChina 5005 55
Shanghai Macklin Biochemical Co.,Ltd. 15221275939021-51821727shenlinxing@macklin.cnChina 13254 55
Shanghai Kangman Biological Technology Co., Ltd. 18800375331021-50908862kangmansales@163.comChina 7634 55
Energy Chemical 021-58432009 / 400-005-6266021-58436166-800info@energy-chemical.comChina 44198 61
Sinopharm Chemical Reagent Co,Ltd. 86-21-6321012386-21-63290778 86-21-63218885sj_scrc@sinopharm.comChina 9988 79
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-55695890 0371-637097260371-63709726xpkchem@163.comChina 4080 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333021-50323701sale@aladdin-e.comChina 28587 65
Yonghua Chemical Technology (Jiangsu) Co., Ltd. +86-512-5254 9999 To 856+86-512-5254 6337wumin@yonghuachem.comChina 687 60
J & K SCIENTIFIC LTD. 400-666-7788;market6@jkchemical.comChina 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comChina 40403 62
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