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Dichloromethane

Chemical property Purification and dehydration method Uses Detriment Distinguishing test Content analysis Toxicity category Hazards & Safety Information

CAS No. 75-09-2
Chemical Name: Dichloromethane
Synonyms: F30;r30;R 30;HCC30;CH2Cl2;Freon30;Nevolin;Driverit;Freon 30;Metaclen
CBNumber: CB7740372
Molecular Formula: CH2Cl2
Formula Weight: 84.93
MOL File: 75-09-2.mol
Dichloromethane Property
Melting point : -97 °C
Boiling point : 39.8-40 °C mm Hg(lit.)
density : 1.325 g/mL at 25 °C(lit.)
vapor density : 2.9 (vs air)
vapor pressure : 24.45 psi ( 55 °C)
refractive index : n20/D 1.424(lit.)
Fp : 39-40°C
storage temp. : Store at RT.
solubility : Miscible in ethyl acetate, alcohol, hexanes, methanol, diethyl ether, n-octanol, acetone benzene, carbon tetrachloride, diethyl ether and chloroform.
Water Solubility : 20 g/L (20 ºC)
Merck : 14,6063
BRN : 1730800
CAS DataBase Reference: 75-09-2(CAS DataBase Reference)
NIST Chemistry Reference: Methylene chloride(75-09-2)
EPA Substance Registry System: Methane, dichloro-(75-09-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xn,T,F,N,C
Risk Statements : 40-39/23/24/25-23/24/25-11-67-36/37/38-68/20/21/22-20/21/22-50-37-34
Safety Statements : 23-24/25-36/37-45-16-7-26-61-36/37/39
RIDADR : UN 1593 6.1/PG 3
WGK Germany : 2
RTECS : PA8050000
F : 3-10
Hazard Note : Harmful
TSCA : Yes
HazardClass : 6.1
PackingGroup : III
Hazardous Substances Data: 75-09-2(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H371 May cause damage to organs Specific target organ toxicity, single exposure Category 2 Warning P260, P264, P270, P309+P311, P405,P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P311 Call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Dichloromethane Chemical Properties,Usage,Production

Chemical property
colorless, transparent, volatile liquid with pungent smell similar to ether. Soluble in water of about 50 times the volume,soluble in phenol, aldehyde, ketone, acetic acid, triethyl phosphate, ethyl acetoacetate, cyclohexylamine. Miscibile with other chlorinated hydrocarbon, solvent ethanol, ethyl ether and N, N-dimethyl formamide
Purification and dehydration method
Dichloromethane is safer than chloroform. So it is often used instead of chloroform as the extractant Heavier than water. Ordinary dichloromethane generally can be used directly as extractant. If purification is needed, it can be washed with 5% sodium carbonate solution, and then washed with water, and then dried with anhydrous calcium chloride, distillated to collect 40~41℃ distillate and stored in a brown bottle.
Uses
The most important use of dichloromethane is solvent. Dichloromethane has a strong solubility, low boiling point and relatively the lowest toxicity and relatively the best reaction inertia, making it the most used organic solvent in the organic synthesis, with almost the same significance of water in inorganic chemistry. It is largely used in the manufacture of safe film, polycarbonate, the rest used as paint solvents, metal degreasing agent, gas aerosol spray, polyurethane foam, mold release agent, paint remover.
it is also used as the reaction medium in the pharmaceutical industry for the preparation of ampicillin, ampicillin and cephalosporin.
Dichloromethane is inert because of the stereoscopic electron effect, and usually does not participate in the chemical reaction. But under certain conditions it can also participate in the reaction. Explosion accident occurred in industry because of the generation of diazomethane methane when residual dichloromethane and sodium azide reacted in N, N-dimethyl formamide.
Dichloromethane is mainly used in film production and medicine in China. Film production accounts for 50% of the total consumption, medicine accounts for 20%, the cleaning agent and chemical industry accounts for 20%, and others accounts for 10%.
Detriment
Health hazards: This product has anesthetic effects, mainly damages the central nervous system and respiratory system. The main route of human exposure is inhalation. It has been determined that methylene chloride is present in high concentrations in indoor production environments when dichloromethane is used as a paint remover. The dose the exposure to general population through the surrounding air, drinking water and food contact is much smaller. It is estimated that about 80% of the world production of methylene chloride is ultimately released into the atmosphere. But the photolysis rate of the compound is so fast that it is impossible to accumulate in the atmosphere. The initial degradation products are phosgene and carbon monoxide, which are then converted into carbon dioxide and hydrochloric acid. When dichloromethane is present in surface water, much of it will evaporate. In the presence of oxygen, it is easy for biodegradation, and thus bioaccumulation of it seems unlikely. But its behavior in the soil is yet to be determined.
toxicity: its oral toxicity is moderate
acute toxicity:LD50 1600~2000mg/kg(rat P.O. acute toxicity);LC50  56.2g/m3,8 hours(inhalation toxicity in mice);mice inhaling 67.4g/m3×67min,dead;human oral 20~50ml,mild intoxicated;human oral 100~150ml,dead;human inhaling 2.9~4.0g/m3×20min, dizzy.
hazardous characteristics:flammable in the case of naked flame or high fever. Its thermal decomposition can emit toxic phosgene. In the case of high fever, the increased pressure within the container may bring about cracking and explosion
Combustion (decomposition) products: carbon monoxide, carbon dioxide, hydrogen chloride, phosgene.
Distinguishing test
Slightly soluble in water, miscible in ethanol and ether
Determination through OT-42 method。
refractive index nD201.423~1.425
density ratio; 1.323~1.327
Content analysis
Dichloromethane can be separated by dibutyl phthalate (DBP), then detected by GC with TCD, and quantified by comparison with standard dichloromethane.
Reagents: carrier gas, helium (> 99.5%); carrier for white diatomaceous earth 6201 (40-60 mesh) or equivalent; stationary phase, DBP (in ether); standard dichloromethane, chromatographically pure dichloromethane;
Instruments: a gas chromatograph with TCD, a column, a 3 m x 3 to 4 mm (inner diameter) stainless steel column.
Conditions: fixed phase, 20%:DBP/6021 gasification temperature, 100℃, detection temperature 100℃; carrier gas flow rate, 70ml/min, column temperature of 70 ℃; TCD bridge current, 200mA ~; injection volume, <20μL; temperature. retention time (R) of other chlorinated solvents related to dichloromethane: methyl chloride 0.15; monochloroethane 0.34; 1,1-dichloroethylene 0.59; monochloropropylene, 0.85; carbon tetrachloride 1.86; chloroform 2.47.
Toxicity
ADI gives no specific stipulation (the residual amount of dichloromethane in the products should be minimized as long as the production demand is meet;FAO/WHO。1998)。
category
pesticide
Hazards & Safety Information
toxicity grade:WHO Class II
acute toxicity:acute peroral LD50 in rats 1600 mg/kg; mouse intraperitoneal LD50: 437 mg/kg
Physiological stimulation:skin-rabbit 810  mg/24hours Severe; eyes-rabbit 500 mg/24hours Mild
Explosive hazard characteristics:Explosive when mixed with air or oxygen
Combustible hazard characteristics:It releases phosgene when heated. Its vapor  is non-flammable
transportation and storing characteristics:In ventilated dry storeroom at low temperature, kept apart from oxidizing agent and nitric acid
extinguishant: Foam extinguisher, carbon dioxide, sprayed water, yellow sand.
professional standard: TWA 350 mg/m3;STEL 879 mg/m3.
Chemical Properties
Colorless liquid
Uses
Meets ACS specifications
Uses
Suitable for HPLC, spectrophotometry, environmental testing
General Description
A colorless liquid with a sweet, penetrating, ether-like odor. Noncombustible by if exposed to high temperatures may emit toxic chloride fumes. Vapors are narcotic in high concentrations. Used as a solvent and paint remover.
Air & Water Reactions
Somewhat water soluble. Subject to slow hydrolysis which is accelerated by light.
Reactivity Profile
Dichloromethane reacts vigorously with active metals such as lithium, sodium and potassium, and with strong bases such as potassium tert-butoxide. Dichloromethane is incompatible with strong oxidizers, strong caustics and chemically active metals such as aluminum or magnesium powders. The liquid will attack some forms of plastic, rubber and coatings. Dichloromethane reacts with sodium-potassium alloy, (potassium hydrogen + N-methyl-N-nitrosurea), nitrogen tetraoxide and liquid oxygen. Dichloromethane also reacts with titanium. On contact with water Dichloromethane corrodes iron, some stainless steels, copper and nickel. Dichloromethane is incompatible with alkali metals. Dichloromethane is incompatible with amines, zinc and alloys of aluminum, magnesium and zinc. Dichloromethane is liable to explode when mixed with dinitrogen pentaoxide or nitric acid. Mixtures of Dichloromethane in air with methanol vapor are flammable.
Health Hazard
INHALATION: anesthetic effects, nausea and drunkenness. CONTACT WITH SKIN AND EYES: skin irritation, irritation of eyes and nose.
Fire Hazard
Special Hazards of Combustion Products: Dissociation products generated in a fire may be irritating or toxic.
Dichloromethane Preparation Products And Raw materials
Raw materials
Chlorine Methanol METHANE
Preparation Products
DI-2-PYRIDYL THIONOCARBONATE (4-IODOPHENYL)ACETONE 3-Bromophenyl isocyanate BENZOYL ISOCYANATE 2-Amino-4,6-bis(difluoromethoxy)pyrimidine 4,5-dimethyl-1,3,2-dioxathiolane 2-oxide DIMETHYL PIMELATE Adriamycin BIS(TRIMETHYLSILYL)PEROXIDE (1,1-DIMETHYL-PROPYL)-HYDRAZINE TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE 3,5-DIBROMO-1H-1,2,4-TRIAZOLE (6R-(6alpha,7))-((Amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 3-ISOCHROMANONE N,N'-Diphenylurea 4-Methylbenzyl isocyanate Benzyl 2-chloroacetate 2,5-DICHLORO-P-XYLENE DIBUTYLBORON TRIFLUOROMETHANESULFONATE 2-Amino-2,3-dimethylbutyramide 4-Bromothiophene-2-carboxaldehyde Tiotropium bromide 4-Biphenylcarbonyl chloride 2-Naphthoyl chloride metaclazepam 2-(2-Butoxyethoxy)ethyl acetate 1-Adamantanecarbonyl chloride 4-DIMETHYLAMINOBENZOYL CHLORIDE 2-CHLORO-5-(TRIFLUOROMETHYL)PHENYL ISOCYANATE dimethyl hexadecyl ammoium butayl sulfate 3-METHOXYPHENYLACETYL CHLORIDE TERT-BUTYL ISOCYANIDE Cyclopentene oxide Bis(acetonitrile)dichloropalladium(II) 2-Bromo-5-nitro-4-picoline Mitomycin C 1-Naphthoyl chloride PYRROLIDINE-1-SULFONYL CHLORIDE (S)-(+)-Methyl glycidyl ether Benzoylferrocene
Dichloromethane Suppliers      Global( 327)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
Huainan Kedi Chemical Factory 0554-2106669
0554-2666215 sales1@kedichem.com China 5005 55
Shanghai Macklin Biochemical Co.,Ltd. 15221275939
021-51821727 shenlinxing@macklin.cn China 13254 55
Shanghai Kangman Biological Technology Co., Ltd. 18800375331
021-50908862 kangmansales@163.com China 7642 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44198 61
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885 sj_scrc@sinopharm.com China 9988 79
Zhengzhou HongSheng Pharmaceutical Co., Ltd. 0371-55695890 0371-55697329
0371-63709726 xpkchem@163.com China 4078 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 sale@aladdin-e.com China 28587 65
Yonghua Chemical Technology (Jiangsu) Co., Ltd. +86-512-5254 9999 To 852
+86-512-5254 6337 chenshuping@yonghuachem.com China 687 60
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96832 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40403 62
 
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