Profenofos | 41198-08-7

Profenofos Properties

Melting point	<25 °C
Boiling point	110°C (0.001 torr)
Density	d20 1.455
vapor pressure	1.24×10^-4 Pa (25 °C)
refractive index	n20D 1.5466
Flash point	124℃
storage temp.	APPROX 4°C
solubility	DMSO: 50 mg/mL (133.82 mM)
Water Solubility	28 mg l^-1 (25 °C)
form	Oily Liquid
Specific Gravity	1.455 (20℃)
Merck	13,7860
BRN	2150258
LogP	4.2 at 25℃
CAS DataBase Reference	41198-08-7(CAS DataBase Reference)
FDA UNII	7J04O7BS4W
NIST Chemistry Reference	Phosphorothioic acid, o-(4-bromo-2-chlorophenyl) o-ethyl s-propyl ester(41198-08-7)
EPA Substance Registry System	Profenofos (41198-08-7)
Pesticides Freedom of Information Act (FOIA)	Profenofos

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS09
Signal word	Warning
Hazard statements	H302+H312+H332-H317-H410
Precautionary statements	P261-P273-P280-P301+P312-P302+P352+P312-P304+P340+P312
Hazard Codes	Xn,N,T
Risk Statements	20/21/22-50/53-24-20/22-43
Safety Statements	36/37-60-61-45-9-7
RIDADR	3018
WGK Germany	3
RTECS	TE6975000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29309090
Toxicity	LD50 in rat (mg/kg): 358-400 orally; ~3300 dermally; LC50 (4 hr) in rat (mg/m3): ~3000 by inhalation (Buholzer); LC50 (96 hr) in rainbow fish: 0.91 mg/l (Kumar, Chapman).

Profenofos price More Price(6)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	45632	Profenofos PESTANAL	41198-08-7	250mg	$132	2024-03-01	Buy
TRC	P755880	Profenofos	41198-08-7	1g	$135	2021-12-16	Buy
Usbiological	287044	Profenofos	41198-08-7	500mg	$410	2021-12-16	Buy
ChemScene	CS-0012846	Profenofos 95.92%	41198-08-7	250mg	$50	2021-12-16	Buy
AK Scientific	I562	Profenofos	41198-08-7	250mg	$81	2021-12-16	Buy

Product number	Packaging	Price	Buy
45632	250mg	$132	Buy
P755880	1g	$135	Buy
287044	500mg	$410	Buy
CS-0012846	250mg	$50	Buy
I562	250mg	$81	Buy

Profenofos Chemical Properties,Uses,Production

Description

Profenofos is a pale yellow liquid, bp 100 ?C/1.80 Pa, vp 0.124 mPa (25 ?C). Solubility in water is 28 mg/L (25 ?C). It is miscible with most organic solvents. Log Kow = 4.44. It is relatively stable in neutral and mild acid media but hydrolyzed in alkaline media; DT₅₀ values (20 ?C) at pH 5, 7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.

Chemical Properties

Profenofos is a pale yellow liquid. Profenofos is relatively stable under neutral and slightly acidic conditions and unstable under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water (28 mg/L at 25°C) but is completely soluble in organic solvents (ethanol, acetone, toluene, n-octanol and n-hexane) at 25°C.

Uses

Profenofos is used to control insects (particularly caterpillars and Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean, potatoes, vegetables, tobacco and a number of other crops

Uses

A broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control.

Uses

Insecticide; acaricide.

Definition

ChEBI: Profenofos is an organic thiophosphate, an organophosphate insecticide, an organochlorine insecticide and a member of monochlorobenzenes. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a 4-bromo-2-chlorophenol.

General Description

Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.

Air & Water Reactions

Hydrolyzed under alkaline conditions.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Agricultural Uses

Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.

Trade name

CGA-15324®; CURACRON®; POLYCRON®; SELECRON®

Carcinogenicity

In a 2 year carcinogenicity study mice were given diets containing 0, 1, 30, or 100 ppm profenofos (equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85 weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related gross or microscopic lesions, tumors, or biologically significant differences in body weight or food consumption were observed between controls and profenofos-treated animals. Plasma and erythrocyte cholinesterase inhibition occurred at dose levels of 4.5 and 15 mg/kg/day. In another carcinogenicity study, rats were fed diets containing 0, 0.3, 10, or 100 ppm profenofos (equivalent to 0, 0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no increase in tumor incidence in any treated group compared to the control group .

Environmental Fate

Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck et al., 1980)
Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen ph
Chemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

The metabolic transformations of profenofos in plants and animals are similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then conjugated.

Metabolism

Profenofos orally administered to rats is rapidly excreted, mainly in the urine. The principal degradation route is hydrolysis to 4-bromo-2-chlorophenol followed by conjugation. DT₅₀ in soil is about 1 week.

Degradation

Profenofos is stable under neutral and slightly acid conditions but it is hydrolysed in alkaline solution. The DT₅₀ values at pH 5, 7 and 9 (20°C) were 93 days, 14.6 days and 5.7 hours, respectively (PM).

Toxicity evaluation

The acute oral LD₅₀ for rats is 358 mg/kg. Inhalation LC50 (4 h) for rats is about 3 mg/L air. NOEL (2 yr) for rats is 0.3 mg/kg diet (0.015 mg/kg/d). ADI is 0.01 mg/kg b.w.

Profenofos Preparation Products And Raw materials

Raw materials

POTASSIUM HYDROGENSULFIDE, 2-Chlorophenol Solvent THIOPHOSPHORYL CHLORIDE 4-Bromo-2-chlorophenol

Chlorobenzene Government regulation Diethyl chlorothiophosphate EMULSIFIER 1-Bromopropane

Phenylphosphonic acid SULPHOSUCCINIC ACID ESTER

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Preparation Products

Phosphorus-containing intermediates of asymmetric organophosphorus pesticides Prothiofos 1-Propanesulfonic acid

Profenofos Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58

Supplier	Advantage
airuikechemical co., ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Shandong chuangyingchemical Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from Profenofos manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Profenofos 41198-08-7	US $0.00-0.00 / Kg	1Kg	99.99%	20 tons	airuikechemical co., ltd.
2020-11-16	Profenofos 41198-08-7	US $8.00 / Kg/Bag	1Kg/Bag	99%	20 Tons	Longyan Tianhua Biological Technology Co., Ltd
2019-07-06	Profenofos 41198-08-7	US $7.00 / KG	1KG	99%	1000KG	Career Henan Chemical Co

Profenofos
41198-08-7
US $0.00-0.00 / Kg
99.99%
airuikechemical co., ltd.

Profenofos
41198-08-7
US $8.00 / Kg/Bag
99%
Longyan Tianhua Biological Technology Co., Ltd

Profenofos
41198-08-7
US $7.00 / KG
99%
Career Henan Chemical Co

Profenofos Spectrum

Profenofos(41198-08-7)MS Profenofos(41198-08-7)IR1

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cga15324 Polycron E.C. Profenofos E.C. O-(4-bromo-2-chlorophenyl) O-ethyl S-propyl phosphorothioate profenofos (ISO) CGA 15324S 4-Bromo-2-chloro-1-(ethoxy-propylsulfanylphosphoryl)oxybenzene O-Ethyl S-propyl O-(2-chloro-4-bromophenyl)thiophosphate O-Ethyl-S-n-propyl-O-(2-chloro-4-bromophenyl)thiophosphate Profeniofos Thiophosphoric acid O-(4-bromo-2-chlorophenyl)O-ethyl S-propyl ester Profenofos Standard Profenofos 250mg [41198-08-7] Calofos Ictacron Prowess TaMbo o-(4-Bromo-2-chlorophenyl) o-ethyl S-propyl thiophosphate FERTIFENOPHOS FORNOFOS CURACRON(R) Curacron(Ciba-Geigy) Polycron Nonacron phosphorothioicacid,o-(4-bromo-2-chlorophenyl)-o-ethyl-s-propylester SANOFOS Selecron SELECRON(R) ROMIFOS PRAHAR POLYCRON(R) POLYCRON PROFENOFOS PESTANAL, 250 MG PROFENOFOS, 250MG, NEAT O-[4-Bromo-2-chloro-phenyl]-O-ethyl-S-n-propyl phosphorothioate S-n-Propyl-O-ethyl-O-2-chloro-4-bromo phenyl thiophosphate profenofos (bsi,iso,ansi,esa) (R,S)-PROFENOFOS Profenofos Profenofos 0.2 Profenofos Solution, 100ppm Profenofos Solution, 1000ppm Probromophos EC Probromophosphorus crude oil Profenofos Solution in Hexane Profenofos@100 μg/mL in MeOH ProfenofosSolution,100mg/L,1ml Profenofos@1000 μg/mL in Acetone ProfenofosSolution,1,000mg/L,1ml ProfenofosSolution,10mg/L,10ml Profenofos 50%EC organic insecticide 41198-08-7 CURACRON PROFENOPHOS PROFENPHOS O-(4-BROMO-2-CHLOROPHENYL)-O-ETHYL-S-PROPYL PHOSPHOROTHIOATE PROFENFOS 41198-08-7 C11H15BrClO3PS Agro-Products Aromatics