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Physicochemical property Main application Excellent flame retardant materials Fixing material Toxicity Chemical property Uses Methods of production

CAS No.420-04-2
Chemical Name:Cyanamide
Synonyms:H2NCN;tsaks;alzogur;CYANAMID;CYANAMIDE;Cyanoamine;usafek-1995;N-Cyanoamine;carbodiamide;USAF ek-1995
Molecular Formula:CH2N2
Formula Weight:42.04
MOL File:420-04-2.mol
Cyanamide Property
Melting point : 45-46 °C(lit.)
Boiling point : 83 °C0.5 mm Hg(lit.)
density : 1,282 g/cm3
refractive index : 1.405
Fp : >230 °F
storage temp. : 2-8°C
Water Solubility : 775 g/L
Sensitive : Hygroscopic
Merck : 14,2684
BRN : 1732569
Stability:: Unstable - heat sensitive. Incompatible with strong oxidizing agents, strong reducing agents, bases, acids, iron and its salts, steel, brass, lead, moisture. Reacts with acids to produce very toxic gas.
CAS DataBase Reference: 420-04-2(CAS DataBase Reference)
NIST Chemistry Reference: Cyanamide(420-04-2)
EPA Substance Registry System: Cyanamide(420-04-2)
Hazard Codes : T
Risk Statements : 21-25-36/38-43
Safety Statements : 3-22-36/37-45-26
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 2
RTECS : GS5950000
HazardClass : 8
PackingGroup : III
Hazardous Substances Data: 420-04-2(Hazardous Substances Data)

Cyanamide Chemical Properties,Usage,Production

Physicochemical property
Cyanamide is also called hydrogen cyanamide,urine anhydride, its scientific name is amino nitrile. It is white orthogonal series crystals, in a diamond shaped, colorless, easy moisture. Melting point is 42℃, boiling point is 83℃ (50.66kPa), vapor pressure is (20℃) is 500MPa. Cyanamide is high solubility in water and weak acid, and completely miscible in water of 43℃. It is soluble in benzene and phenol, alcohols, amines, ethers, ketones, slightly soluble in benzene, halogenated hydrocarbons, but insoluble in epoxy ethane, cyclohexane. Solubility (20℃ ): water 4.59kg/L, methyl ethyl ketone 505g/kg, acetic acid ethyl ester 424g/kg, octanol 288g/kg, chloroform 2.4 g/kg. It can volatilize with water vapor, so it can dissolve in a series of solvents. In polar organic solvent, solubility is large, and in non-polar solvents is smaller. Crystal cyanamide is not stable, large polarity. Due to the cyanamide molecular structure containing the cyano and amino, both of which are active groups, it has the functional groups of the multiple reaction performance, prone to addition, substitution, condensation reaction. It is stable to light. It decomposites to dicyandiamide and polymers in alkali, and decomposites to urea in acid. It decompose when heated to 180℃. Product has four kinds of crystal of 25%, 40%, 50% and 90%. 25% of cyanamide solution is mainly used for creatine production, 50% and 90% of cyanamide solutions are mainly used for producing methylene urea pharmaceutical intermediates.
Three-dimensional structure of cyanamide
Figure 1 Three-dimensional structure of cyanamide
Main application
1. Important pharmaceutical raw material
Cyanamide is mainly used for the production of hydrochloric acid cytarabine, dye intermediate 3-amino-5-hydroxy-1,2,4-nitrogen azole, cyanide urea amine, melamine methyl carbamate, cyanide urine amide, thiourea, carbendazim. It is also raw material for preparation of organic guanidine, then the product pharmaceutical barbituric acid, sulfa drugs and guanidine salt, etc. It can also be used for production anticancer drugs of fluorouracil in medicine. Cyanamide calcium salt can be used for clinical treatment of alcoholism and anthelmintic action.
2. Raw materials for chemical pesticides
2.1 Cyanamide can be used as chemical raw materials of no residue, low toxicity, broad-spectrum pesticide, and can also be used for production of antibacterial agent such as carbendazim, benzene benomyl, methyl mepanipyrim and mepanipyrim, Pirimicarb, pyrimidinoxy phosphorus, herbicide Chlorsulfuron, Metsulfuron methyl, Metsulfuron methyl ethyl, long ether tribenuron methyl and bensulfuron methyl and pyrazole ethyl, hexazinone, etc. It has the significance of technological innovation for pesticide production, solves the environmental pollution while the general pesticide production enterprises can be difficult to solve the problem using calcium cyanamide in the production of pesticide. So using cyanamide can save equipment investment, reduce production costs.
2.2 In recent years, cyanamide is used as off leaf agents, herbicides and pesticides in abroad, but also can be used as pesticide, and cyanamide has a certain of nitrogen application effect. Cyanamide solution was used as a defoliant, non-toxic pesticides for fruit trees in abroad.
2.3 The cyanamide in agriculture can be used as plant growth regulators, with both pesticidal and bactericidal effects. Directly sprayed on crops, can effectively inhibit the activity of catalase in plants, accelerate plant oxidative pentose phosphate (PPP) circulation, thus speeding up the generation of basic substances in plants, play a role in the regulation of growth. The field efficacy trials showed that It can regulate the growth and increase production of cherries and grapes. Before 15 to 20 days in grape germination, it sprayed evenly on the branches, uniform of a drug on bud eye, can advance germination of 7 to 10 days. For early flowering, full flowering stage, coloring period and mature period, using it can aslo advance early. At the same time it is good dormancy terminating agent in the production of kiwi, cherries, grapes. it sprayed evenly on bud eye in the dormant period, it can break the dormancy period, can be early germination, early flowering, early mature and early on the market. It can significantly improve the yield, change fruit fleshy and improve the quality of varieties.
Excellent flame retardant materials
The cyanamide is mainly used for production of flame retardant agent such as o-methyl isourea, creatine, guanidine phosphate. At the same time, as a kind of flame retardant material with excellent performance, cyanamide polyols and polyether solution are used for production of polyurethane, can significantly improve the flame retardancy of polyurethane material, which is a new type of fine chemical new materials.
Fixing material
The materials from the two polymer fixing agent melamine dicyandiamide can be used in the production of fixing agent Y, fixing agent G, fixing agent M and fixing agent B. Reaction product of cyanamide, poly formaldehyde and acid copper is fixing agent B, which is gray powder, can be used for direct dyes and staining after treatment. 30.9 copies of diethylenetriamine and 24.8 dicyandiamide react under 100℃, then reaction again in 155 ℃, after 5h cooling, crushing to obtain colorless powder. It is a kind of formaldehyde-free fixing agent, low cost, having a development promising as green products.
1. It has the skin irritation and corrosive, can lead to severe dermatitis, the person suction can cause mucosal irritation, transient flushing, headache, dizziness, shortness of breath, tachycardia and hypertension and other symptoms.
2. Mutagenicity test: mild irritation to rabbit skin and eye severe stimulation, the drug of guinea pig skin allergic reaction test is attenuated sensitive drugs.
3.The effect maximum dose is 0.2mg/kg/d in rats with 90d sub chronic feeding experiment. Cyanamide drug and 50% aqueous solution are medium toxicity. Please use it to Caution!
Chemical property
Pure cyanamide is a transparent liquid, m.p.-115℃, b.p.-8.5℃, soluble in alcohols, phenols, amines, ethers, easily soluble in benzene, alkyl halides, 77.5% of it is soluble in water of 15℃. The high concentration of cyanamide is not stable, easy polymerization, often adding stabilizer. General merchandise for 50% of cyanamide solution, n20D 1.4050, the relative density is 1.082.
1.Cyanamide is an important intermediate of pesticide. It can also be used for production of antibacterial agent such as carbendazim, benzene benomyl, methyl mepanipyrim and mepanipyrim, Pirimicarb, pyrimidinoxy phosphorus, herbicide Chlorsulfuron, Metsulfuron methyl, Metsulfuron methyl ethyl, long ether tribenuron methyl and bensulfuron methyl and pyrazole ethyl, hexazinone, etc.
2. In the pharmaceutical industry, it is used as a raw material for the production of hydrochloric acid. It is also used for the production intermediates of 3-amino-5-hydroxyl-1,2,4-triazol in the dye industry. In addition, for organic synthesis and plastic raw materials, it can be used for production of cyanuric amide, dicyandiamide, cyanide methyl carbamate etc.
3.Cyanamide liquid is used for industrial raw materials, pharmaceutical intermediates, agricultural pesticides, fertilizer, plant growth regulator, food additives etc.
4. Used in the production of materials such as urine.
Methods of production
1.It is gotten by the reaction of lime nitrogen with sulphuric acid。
The preparation method is based on the lime nitrogen as raw material, reaction with sulfuric acid is made. In the reactor, the water is putted, with ice water cooling, lime nitrogen input, the temperature was kept between 0 to 15℃, dropping 5% of sulfuric acid solution, adjusting the pH = 6 and holding 20 min. Then filtration, washing, and then return to a reaction kettle, added lime nitrogen, repeat the above operation 2 times, the obtained filtrate is through membrane thickening, keeping a certain temperature, concentrated content reached 50%~55%, Cyanamide solution of 50% is obtained.
Reaction equation: CaCN2+H2O+H2SO4-> NH2CN+CaSO4
2. Urea process。
Chemical Properties
white crystalline solid
General Description
Colorless deliquescent crystals. Mp: 45°C; bp: 260°C. Density: 1.282 g cm-3. Quite soluble in water (77 g / 100 g solution at 15°C). Soluble in butanol, methyl ethyl ketone, ethyl acetate, alcohols, phenols, amines, ethers. Note: The term "Cyanamide" is also used to refer to the important compound calcium Cyanamide, which is a different chemical.
Reactivity Profile
Cyanamide is the amide of cyanic acid. Non-flammable but combustible (flash point: 140°C). Decomposes on warming above 49°C. Emits toxic fumes of CN- and NOx when heated to decomposition or on contact with acids or acid fumes (Hazardous Chemicals Desk Reference, p. 353 (1987)). Contact with moisture, acids or bases may cause a violent reaction at temperatures above about 40°C. Dry solid may polymerize at temperatures above 122°C. Rapid or explosive polymerization may occur during the evaporation of aqueous solutions. Reacts explosively with strong oxidizing agents and strong reducing agents. Attacks various metals (International Chemical Safety Card).
Cyanamide Preparation Products And Raw materials
Raw materials
Calcium cyanamide SULFURIC ACID
Preparation Products
2-AMINO-4-METHYLOXAZOLE 1-Methyl-3-nitro-1-nitrosoguanidine 1H-1,2,4-TRIAZOLE-1-CARBOXAMIDINE MONOHYDROCHLORIDE Dicyanodiamide N-Cyanoimido-S,S-dimethyl-dithiocarbonate Bensulfuron methyl Aminoguanidine bicarbonate CHLOROFORMAMIDINE HYDROCHLORIDE L-Alanine 2,4-DIAMINO-1,3,5-TRIAZINE 2,2'-Anhydro-1-beta-D-arabinofuranosylcytosine hydrochloride 2,5-Diaminopyrimidine 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE FORMAMIDINE HYDROCHLORIDE Triazol-3-amine Diphenyl N-cyanocarbonimidate Oxazole-2-amine IMINOCTADINE TRIACETATE DL-Alanine
Cyanamide Suppliers      Global( 174)Suppliers     
Alfa Aesar 400-610-6006; 021-67582000021-67582001/03/05saleschina@alfa-asia.comCHINA 30324 84
Credit-Chem Co., Ltd. 400-821-5857 021-64326257021-64393586 QQ;2798200800credit-chem@foxmail.comCHINA 5278 58
Shanghai Rolead Chemical Technology Co., Ltd. 021-69992230 / 69992220021-69992237roleadchem@163.comCHINA 4642 50
Anhui Royal Chemical Co., Ltd. +86-25-86736275+86-25-52279193dana.jiang@royal-chem.comCHINA 636 60
J & K SCIENTIFIC LTD. 400-666-7788;market6@jkchemical.comCHINA 96835 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing)+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing)sh@meryer.comCHINA 40405 62
Beijing dtftchem Technology Co., Ltd. 13651141086; 86(10)60275028、6027582086 (10) 60270825dtftchem@sina.comCHINA 1447 62
BeiJing Hwrk Chemicals Limted 4006990298;010-57411839;0757-86311057;021-51691807010-87653215;0757-86311057;021-55236763sales@hwrkchemical.comCHINA 16343 55
Energy Chemical 021-58432009 / 400-005-6266021-58436166-800info@energy-chemical.comCHINA 44199 61
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028+86-10-82967029sales@ouhechem.comCHINA 10821 60
420-04-2(Cyanamide)Related Search:
alzogur Amidocyanogen carbamonitrile carbodiamide Cyanoamine Cyanogen nitride Cyanogenamide cyanogennitride H2NCN hydrogencyanamid N-Cyanoamine tsaks USAF ek-1995 usafek-1995 CARBODIIMIDE CYANAMIDE F1000 CYANAMIDE L500 CYANAMID CYANAMIDE HYDROGEN CYANAMIDE Building Blocks C1 to C5 420-04-2 Organic Building Blocks Nitrogen Compounds Cyanides/Nitriles Cyanamide solution Aminonitrile Carbamic acid nitrile cyanamide,urea anhydride CYANAMIDE, 50 WT. % SOLUTION IN WATER CYANAMIDE, STAB. Cyanamide, stabilized, 95% CH2N2 CN2H2 Pharmaceutical Intermediates CYANAMIDE , STAB. WITH 0.5% PHOSPHORIC ACID CYANAMIDE IN 50% WATER SOLUTION Inorganics 420-04-4 Cyanamide, 50% w/w aq. soln. Cyanamide, 98+%, stab. with ca 0.5% phosphoric acid Carbaminonitrile 420-14-2 cyanamide carbanonitril C1 to C5 Cyanides/Nitriles Nitrogen Compounds Carbodiimide, Hydrogen cyanamide NCNH2 NH2CN Cyanamide, 95%, stabilized Amino cyanide Carbamic nitrile Cyanamide,50 wt.% in water, stabilized with phosphoric acid Cyanamide, 98+%, stab. Cyanamide, 50% w/w aq. soln., stab. Cyanamide,50% aq solution
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