에르고칼시페롤
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에르고칼시페롤 속성
- 녹는점
- 114-118 °C(lit.)
- 알파
- 82 º (c=3, in acetone 25 ºC)
- 끓는 점
- 460.3°C (rough estimate)
- 밀도
- 0.9784 (rough estimate)
- 증기압
- 7 x l0-7 Pa (20 °C), est.)
- 굴절률
- 1.5100 (estimate)
- 인화점
- 14 °C
- 저장 조건
- -20°C
- 용해도
- H2O: 200 mg/mL, 투명하거나 흐릿함
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 14.74±0.20(Predicted)
- 색상
- 흰색에서 노란색을 띤다
- optical activity
- [α]20/D +105±2°, c = 4% in ethanol
- 수용성
- 에탄올, 물, 메탄올, 디메틸포름아미드, 디메틸설폭사이드에 용해됩니다.
- Merck
- 14,10018
- BRN
- 1916682
- BCS Class
- 3
- 안정성
- 감광성
- InChIKey
- MECHNRXZTMCUDQ-RKHKHRCZSA-N
- LogP
- 10.440 (est)
- CAS 데이터베이스
- 50-14-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,T+,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 22-48/25-26-24/25-40-23/24/25-48/22-23-11-20 | ||
안전지침서 | 28-36/37-45-28A-36-26-36/37/39-22-16-7 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | KE1050000 | ||
F 고인화성물질 | 1-8-10 | ||
TSCA | Yes | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29362900 | ||
유해 물질 데이터 | 50-14-6(Hazardous Substances Data) | ||
기존화학 물질 | KE-05-1146 | ||
유해화학물질 필터링 | 97-1-186 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 에르고칼시페롤 및 이를 1% 이상 함유한 혼합물 |
에르고칼시페롤 C화학적 특성, 용도, 생산
순도시험
(1) 비선광도 : 이 품목 약 0.3g을 정밀히 달아 에탄올에 녹여 20mL로 하고 이 액의 선광도를 측정할 때, =+102~+107°이어야 한다.
(2) 비흡광도 : 이 품목을 알데히드를 함유하지 않은 에탄올에 녹여 파장 265nm에서 흡광도를 측정할 때, =445~485이어야 한다.
(3) 에르고스테롤 : 이 품목 10mg을 90% 에탄올 2mL에 녹이고 디기토닌 20mg을 90% 에탄올 2mL에 녹인 액을 가하여 18시간 방치할 때, 침전이 생겨서는 아니 된다.
(4) 융점 : 이 품목의 융점은 115~119℃이어야 한다.
확인시험
(1) 이 품목 50mg을 무수피리딘 1mL에 녹이고 3,5-디니트로염화벤조일 50mg을 무수피리딘 1mL에 녹인 액을 가하여 수욕상에서 10분간 가열한다. 식힌 다음 물 5mL를 가하여 생긴 침전을 여과하고 물로 씻은 다음 아세톤을 용매로 하여 2회 재결정하여 감압데시케이타(황산)에서 2시간 건조할 때, 그 융점은 147~149℃이다.
(2) 이 품목 0.5mg을 클로로포름 5mL에 녹이고 무수초산 0.3mL 및 황산 0.1mL를 가하여 흔들어 섞으면 적색을 나타내고 이어 자색, 청색을 거쳐 녹색으로 변한다.
개요
Vitamin D aids in the absorption of calcium and has central roles in bone formation and maintenance, hypertension, cancer and immunity. Vitamin D may be obtained from many dietary sources, including eggs and fish, and is synthesized in the skin by the conversion of 7-화학적 성질
Ergocalciferol is an odorless white crystalline solid용도
Vitamin d2 is fat-soluble, and is stable unless oxidized. It is necessary for growth and maintenance of teeth and bones and the normal utilization of calcium and phosphorus; it is used medicinally in the treatment of rickets and as a dietary supplement. Its sources include fish liver and vitamin d-fortified milk.정의
ChEBI: A vitamin D supplement and has been isolated from alfalfa.일반 설명
Odorless white crystals. Used as a dietary supplement and food additive.반응 프로필
Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.건강위험
Vitamin D2 poisoning disturbs calcium metabolism and causes kidney damage. Vitamin D2 in a single acute ingestion presents no toxic hazards. Daily ingestion in excess of 5000 units/day in children or 7500 units/day in adults will produce toxic symptoms associated with hypervitaminosis D. Those with hypercalcemia are at a greater risk.화재위험
Shows signs of decomposition when stored for a few days at room temperature.Safety Profile
Poison by ingestion, intraperitoneal, intravenous, and intramuscular routes. An experimental teratogen. Human systemic effects by ingestion: anorexia, nausea or vomiting, and weight loss. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.잠재적 노출
Used as a nutrient and/or dietary supplement food additive신진 대사 경로
Ergocalciferol (vitamin D2) is a product made by the UV irradiation of yeast ergosterol. It is a common form of vitamin D and it has very similar biological activity to that of cholecalciferol (vitamin D3) in the treatment of the vitamin D deficiency diseases (e.g. rickets). The bioactive form of this vitamin is also the 1,25-dihydroxy-derivative and this has equal antirachitic activity to that of the cholecalciferol analogue (Jones et al., 1975).운송 방법
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materialsPurification Methods
It is converted into its 3,5-dinitrobenzoyl ester and crystallised repeatedly from acetone. The ester is then saponified and the free vitamin is isolated. [Laughland & Phillips Anal Chem 28 817 1956, Beilstein 6 IV 4404.]비 호환성
Dust may be combustible and may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.폐기물 처리
Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed. It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffeegrounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.에르고칼시페롤 준비 용품 및 원자재
원자재
준비 용품
25-HYDROXYVITAMIN D2
VitaMin D2 Tosylate
(1R,3aR,7aR)-1-((2R,5S)-5,6-diMethylheptan-2-yl)-7a-Methyloctahydro-1H-inden-4-ol
Vitamin D2 SO2 Adduct
(3S)-1,3-Bis-O-tert-ButyldiMethylsilyl 3-Hydroxy VitaMin D2 SO2 Adduct (Mixture of DiastereoMers)
tert-Butyl-dimethyl-{3-[7a-methyl-1-(1,4,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2l6-benzo[c]thiophen-5-yloxy}-silane
에르고칼시페롤 공급 업체
글로벌( 696)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 941 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |