ChemicalBook > Product Catalog >API >Circulatory system drugs >Lipid regulating drugs >Fluvastatin sodium salt

Fluvastatin sodium salt

Fluvastatin sodium salt Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Fluvastatin sodium salt
CAS:93957-55-2
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  Gold
Tel:020-39119399 18927568969
Email:isunpharm@qq.com, isunpharm@hotmail.com
Products Intro:CAS:93957-55-2
Purity:>98% Package:1g;5g;50g;500g;5kg;25kg Remarks:>99%,BR
Company Name: J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market6@jkchemical.com
Products Intro:Product Name:Fluvastatin SodiuM Salt Hydrate
CAS:93957-55-2
Purity:98.0%(LC&N) Package:1G,5G
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel:86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:3bsc@sina.com
Products Intro:Product Name:Fluvastatin sodiuM;(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-Methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoicacidsodiuMsalt
CAS:93957-55-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: JIANGXI AIFEIMU TECHNOLOGY CO.,LTD  
Tel:+86-570-6040288, 6040289
Email:sales@afmpharm.com
Products Intro:Product Name:(E)-3,5-dihydroxy-7-[3'-(4"-fluorophenyl)-1'-methylethyl-indol-2'-yl] hept-6-enoate
Purity:99% Package:5KG
Fluvastatin sodium salt Basic information
Commonly used cholesterol-lowering drugs Chemical Properties Uses production method
Product Name:Fluvastatin sodium salt
Synonyms:(+/-)-(3R',5S',6E)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYLINDOL-2-YL]-3,5-DIHYDROXY-6-HEPTENOATE, SODIUM;FLUVASTATIN NA;FLUVASTATIN SODIUM;FLUVASTATIN SODIUM SALT;sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate;(r*,s*-(e))-monosodiumsal(+-)-2-yl);3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-6-heptenoicaci;5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl)-monosodiumsalt,(r*,s*-(e))-(6-heptenoicaci
CAS:93957-55-2
MF:C24H25FNNaO4
MW:433.45
EINECS:
Product Categories:Antihyperlipoproteinemic;Intermediates & Fine Chemicals;Pharmaceuticals;HMG-CoA reductase;API;API Reference Standard
Mol File:93957-55-2.mol
Fluvastatin sodium salt Structure
Fluvastatin sodium salt Chemical Properties
Melting point 194-197°C
storage temp. Desiccate at -20°C
solubility H2O: ≥9mg/mL
color white to tan
CAS DataBase Reference93957-55-2(CAS DataBase Reference)
Safety Information
RTECS MJ9675050
MSDS Information
Fluvastatin sodium salt Usage And Synthesis
Commonly used cholesterol-lowering drugsFluvastatin sodium salt is commonly used as a cholesterol-lowering drug, cholesterol-lowering effect is very good, the trade name of the commercially available products is Lescol,which is produced by Novartis. Fluvastatin sodium salt is a fully synthetic cholesterol-lowering drug, it belongs to methylglutaryl coenzyme A (HMC-CoA) reductase inhibitors, the main function is performed in the liver ,it can transform HMG-CoA into 3-methyl-3,5-dihydroxy acid, it can inhibit the synthesis of endogenous cholesterol ,and reduce cholesterol content in liver cells, it can stimulate the synthesis of low density lipoprotein (LDL) receptors,and enhance the uptake of LDL particles, reduce the plasma total cholesterol concentration.it can significantly reduce total cholesterol, LDL cholesterol, triglycerides, and increase high-density lipoprotein cholesterol.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesMelting point 194~197 ℃.
UsesHMG-CoA reductase inhibitors.
production method1. After condensation of (chloroacetyl) fluorobenzeneand N-isopropyl aniline , the compound (I) is obtained. Then in acetonitrile, under the presence of phosphorus oxychloride, react with N, N-dimethylamino acrolein , the compound (Ⅱ) is obtained. Compound (Ⅱ) in the role of a strong base, after condensation with methyl acetoacetate , and then splitting ,the compound (Ⅲ) is produced. At-77 ~-74 ℃, the compound (Ⅲ) is added dropwise into a mixture of boron sodium borohydride , methanol, tetrahydrofuran and diethyl methoxy ,stir 30min; cyclic boronic ester obtained in ethyl acetate is treated with 30% hydrogen peroxide; then it is hydrolyzed to obtain fluvastatin sodium.
2. the compound (Ⅳ)is obtained by catalytic hydrogenation of Phloroglucinol . React it With tert-butyldiphenylsilyl chloride to produce the compound (V), and then oxidize it to generate (Ⅵ). After oxidation of chloroperbenzoic acid to obtain (Ⅶ), (Ⅷ) is produced through ring-opening . And then it is oxidized to (IX) . (Ⅺ) is obtained through condensation of (Ⅸ) and intermediate x , after deprotection and hydrolysis, obtain fluvastatin sodium. Intermediate (X) can be made through starting from the compound (I), via formylation, reduction, chlorination, and then reacting with triphenylphosphine .
Chemical PropertiesYellow Powder
UsesA synthetic HMG-CoA reductase inhibitor. Antilipemic
UsesAnti- hyperlipoproteinemic;'HMG CoA reductase inhibitor
Biological ActivityOrally active, potent and competitive HMG-CoA reductase inhibitor (IC 50 = 40 -100 nM at human liver microsomes). Inhibits vascular smooth muscle proliferation in vitro (IC 50 = 70 nM) and exhibits antihypercholesterolemic and antioxidant activity in vivo .
Tag:Fluvastatin sodium salt(93957-55-2) Related Product Information
Sodium bicarbonate Sodium benzoate Sodium carbonate sodium Pravastatin sodium FLUVASTATIN[METHYL-(±)-(E)-7-[3’-(4”-FLUOROPHENYL )-1’-(1”-METHYLETHYL)INDOL-2’-YL]-3,5- DIHYDROXY-6- HEPTENOATE ],FLUVASTATIN,FLUVASTATIN NA,FLUVASTATIN SODIUM,FLUVASTATIN SODIUM 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Sodium chloride Chlorodimethylphenylsilane (2-Methoxyethyl)benzene 2-Butanone ATORVASTATIN SODIUM 1-Hydroxyethylidene-1,1-diphosphonic acid Silicone oil (high temperature) Sodium formate Sodium acetate Diclofenac sodium Sodium gluconate