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Propafenone Hydrochloride

Propafenone Hydrochloride Suppliers list
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-15965530500 +86-15965530500
Email: nickzhang@hangyubiotech.com
Products Intro: Product Name:Propafenone Hydrochloride
CAS:34183-22-7
Purity:0.99 Package:1kg;100USD|10kg;1000USD
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Email: sales@frappschem.com
Products Intro: Product Name:Propafenone Hydrochloride
CAS:34183-22-7
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:Propafenone Hydrochloride API
CAS:34183-22-7
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
Email: product@chemlin.com.cn
Products Intro: CAS:34183-22-7
Purity:98% Package:g-Kg
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682
Email: bruce@xrdchem.cn
Products Intro: Product Name:Rytmonorm
CAS:34183-22-7
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:White solid

Propafenone Hydrochloride manufacturers

  • PROPAFENONE HCL
  • PROPAFENONE HCL pictures
  • $25.00 / 1KG
  • 2023-03-27
  • CAS:34183-22-7
  • Min. Order: 1KG
  • Purity: 0.99
  • Supply Ability: 5000kg/month
Propafenone Hydrochloride Basic information
Product Name:Propafenone Hydrochloride
Synonyms:1-[2-(2-HYDROXY-3-[PROPYLAMINO]-PROPOXY)PHENYL]-3-PHENYL-1-PROPANONE HYDROCHLORIDE;1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride;sa79;wz884;Arythmol;Rytmonor;Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride (8CI);1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanonhydroc
CAS:34183-22-7
MF:C21H28ClNO3
MW:377.9
EINECS:251-867-9
Product Categories:Inhibitors;Amines;Aromatics;Sodium channel;Intermediates & Fine Chemicals;Pharmaceuticals;34183-22-7
Mol File:34183-22-7.mol
Propafenone Hydrochloride Structure
Propafenone Hydrochloride Chemical Properties
Melting point 165-1670C
storage temp. 2-8°C
solubility Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
color White to Off-White
λmax303nm(MeOH)(lit.)
Merck 14,7794
CAS DataBase Reference34183-22-7(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xn
Risk Statements 46-22
Safety Statements 53-36/37/39-45
WGK Germany 3
RTECS UH2833000
HS Code 2922504500
ToxicityLD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)
MSDS Information
ProviderLanguage
SigmaAldrich English
Propafenone Hydrochloride Usage And Synthesis
DescriptionPropafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemical PropertiesWhite Solid
UsesPropafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
UsesSodium channel blocker. Antiarrhythmic (class IC)
DefinitionChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Brand nameRythmol (Reliant).
PharmacokineticsPropafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Clinical UseAnti-arrhythmic agent:
Ventricular arrhythmias
Paroxysmal supraventricular tachyarrhythmias, (including paroxysmal atrial flutter or fibrillation, and paroxysmal re-entrant tachycardias involving the AV node or accessory pathway) where standard therapy has failed or is unsuitable
Drug interactionsPotentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression with other anti-arrhythmics.
Antibacterials: increased metabolism with rifampicin (reduced effect).
Anticoagulants: enhanced anticoagulant effect of coumarins.
Antidepressants: increased risk of arrhythmias with tricyclics; metabolism of propafenone possibly inhibited by paroxetine (increased risk of toxicity).
Antihistamines: increased risk of ventricular arrhythmias with mizolastine - avoid.
Antipsychotics: increased risk of ventricular arrhythmias with antipsychotics that prolong the QT interval.
Antivirals: concentration of propafenone increased by saquinavir and ritonavir and possibly by fosamprenavir, increased risk of ventricular arrhythmias - avoid; use with caution with telaprevir.
Beta-blockers: increased myocardial depression; increased concentration of metoprolol and propranolol.
Cardiac glycosides: increased digoxin concentration - halve digoxin dose.
Ciclosporin: possibly increased ciclosporin concentration.
Ulcer-healing drugs: levels increased by cimetidine.
MetabolismPropafenone is hepatically metabolised mainly by CYP2D6 isoenzyme but also to a small extent by CYP1A2 and CYP3A4. This forms 2 active metabolites, 5-hydroxypropafenone and N-depropylpropafenone and some inactive ones. Propafenone and its metabolites also undergo glucuronidation. The extent of metabolism is genetically determined.
Propafenone is excreted in the urine and faeces mainly in the form of conjugated metabolites.
Propafenone Hydrochloride Preparation Products And Raw materials
Raw materialsBenzaldehyde-->2'-Hydroxyacetophenone-->2'-(Oxiranylmethoxy)-3-phenylpropiophenon-->2'-Hydroxychalcone-->2'-Hydroxy-3-phenylpropiophenone-->Propylamine
Tag:Propafenone Hydrochloride(34183-22-7) Related Product Information
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