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| 2-Methyl-3-biphenylmethanol Basic information |
| 2-Methyl-3-biphenylmethanol Chemical Properties |
Melting point | 73-76 °C(lit.) | Boiling point | 330.9±11.0 °C(Predicted) | density | 1.072±0.06 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | solubility | Chloroform (Slightly), Methanol (Slightly) | pka | 14.28±0.10(Predicted) | form | Solid | color | White to Off-White | InChI | InChI=1S/C14H14O/c1-11-13(10-15)8-5-9-14(11)12-6-3-2-4-7-12/h2-9,15H,10H2,1H3 | InChIKey | BGTLHJPGBIVQLJ-UHFFFAOYSA-N | SMILES | C1(C2=CC=CC=C2)=CC=CC(CO)=C1C | CAS DataBase Reference | 76350-90-8(CAS DataBase Reference) | EPA Substance Registry System | [1,1'-Biphenyl]-3-methanol, 2-methyl- (76350-90-8) |
WGK Germany | 3 | HS Code | 2906290090 |
| 2-Methyl-3-biphenylmethanol Usage And Synthesis |
Description | 2-Methyl-3-biphenylmethanol is a pharmaceutical intermediate and organic chemical synthesis reagent, which can be used in the preparation of drugs such as Bifenthrin and PD-L1 inhibitors, and also in the synthesis of other organic compounds such as 2-methyl-3-phenylphenethylboronic acid pinacol ester, biphenyl-1,2,3-triazole couplings and biphenyl alcohols. | Chemical Properties | white to light yellow crystal powde | Uses | Bifenthrin intermediate. | Synthesis |
Carrying out a Suzuki coupling reaction between 3-bromo-2-methylbenzoic acid and phenyl substituted boric acid or phenyl substituted borate to obtain 3-phenyl-2-methylbenzoic acid, and then carrying out a reduction reaction to obtain 2-Methyl-3-biphenylmethanol, wherein the Suzuki coupling reaction is carried out at 10-150 DEG C for 1-12 hours under the action of an alkali. 3-phenyl-2-methylbenzoic acid can be directly reduced with a reducing agent such as borane and lithium aluminium hydride to obtain 2-Methyl-3-biphenylmethanol.
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| 2-Methyl-3-biphenylmethanol Preparation Products And Raw materials |
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