ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Ibuprofen


Ibuprofen Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:Ibuprofen
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Products Intro: Product Name:Ibuprofen
Purity:98% Package:99/KG
Company Name: Boen pharm  Gold
Tel:86 512-62572107 62962707
Products Intro:Product Name:Ibuprofen
Company Name: Guangzhou Kafen Biotech Co.,Ltd  Gold
Tel:020-31121484 18027468163 QQ:2355327168
Products Intro:Product Name:Ibuprofen
Purity:99% Package:1KG;5KG;25KG
Company Name: Accela ChemBio Co.,Ltd.  Gold
Products Intro:Product Name:2-(4-Isobutylphenyl)propanoic Acid
Purity:97+% Package:5g;25g;100g;500g Remarks:SY006202
Ibuprofen Basic information
description Indications overdose Precautions Drug Interactions Side Effects
Product Name:Ibuprofen
Product Categories:Active Pharmaceutical Ingredients;API;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Lipid signaling;Isotopically Labeled Pharmaceutical Reference Standard;ADVIL;Other APIs;Pharmaceutical ingredients
Mol File:15687-27-1.mol
Ibuprofen Structure
Ibuprofen Chemical Properties
Melting point 77-78 °C(lit.)
Boiling point 157 °C (4 mmHg)
Fp 9℃
storage temp. -20?C Freezer
form Crystalline Powder
color white to off-white
Water Solubility insoluble
Merck 14,4881
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference15687-27-1(CAS DataBase Reference)
NIST Chemistry ReferenceIbuprofen(15687-27-1)
EPA Substance Registry SystemBenzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)- (15687-27-1)
Safety Information
Hazard Codes Xn,N,T,F
Risk Statements 22-63-51/53-39/23/24/25-23/24/25-11
Safety Statements 36-61-36/37-45-16-7
WGK Germany 3
RTECS MU6640000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data15687-27-1(Hazardous Substances Data)
MSDS Information
2-(4-Isobutylphenyl)-propionic acid English
SigmaAldrich English
ACROS English
ALFA English
Ibuprofen Usage And Synthesis
descriptionIbuprofen is a nonsteroidal anti-inflammatory analgesic. Its anti-inflammatory, analgesic and antipyretic effect is good, has less adverse reactions. Nowadays, it has already widely used in the world, and is to become one of the most popular over-the-counter medications in the world, and is listed as antipyretic analgesic three pillars products with aspirin, acetaminophen.
Ibuprofen was co-found by Dr Stewart Adams (later became a professor and was awarded a MBE) and his leadership team, scientific research expert CoLinBurrows, chemical expert Dr John Nicholson. The original research purpose was invention of a "super aspirin", to replace drug of aspirin with less serious adverse reactions for the treatment of rheumatoid arthritis. And other drugs, such as Bute, has a greater risk of agranulocytosis occurred; Corticosteroid drugs, larger dosage than ordinary prescription dose brings the adrenal suppression and other adverse reactions, such as high risk of gastrointestinal ulcers, etc. Adams decided to find a drug with good gastrointestinal tolerance, this feature for all classes of non-steroidal anti-inflammatory drugs (nsaids) are particularly important on the current.
Indications1, relieve rheumatoid arthritis, osteoarthritis, spinal arthritis, gouty arthritis, rheumatoid arthritis and other acute phase of chronic arthritis or continuous joint swelling pain symptom, etiology, treatment and control course of action.
2, treatment of non joint rheumatic pain every soft tissue, shoulder pain, tenosynovitis, slippery bursa phlogistic, muscle pain and injury pain after exercise, etc.
3, acute mild and moderate pain such as surgery, trauma, strain after, primary dysmenorrhea, toothache, headache, etc.
4, has antipyretic effect of adults and children fever.
overdoseIbuprofen is a type of nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen overdose occurs when someone accidentally or intentionally takes more than the normal or recommended amount of this medication.
Can you overdose on ibuprofen? For adults, the maximum dose of ibuprofen is 800 milligrams (mg) per dose. It may be taken up to a maximum of four doses per day or a total of 3200 mg daily. If you take too much ibuprofen, unpleasant side effects may develop and this may require immediate medical attention.
How much ibuprofen can kill you? Animal research shows that the lethal dose that kills 50% of test animals (LD50) of oral ibuprofen is 636 mg/kg. If this value is applied to humans, it may take 191 tablets (200mg/tablet) or a total of 38,160 mg for a 60-kg man to die from acute ibuprofen overdose. The effects of ibuprofen at lesser doses (600-800mg) also include upset stomach, which can lead to internal bleeding and death, over a long time. Taking higher doses (1200-1600mg) can make you sick and throw up, but not enough to kill you at once.
Precautions1, used in the late pregnant women can prolong pregnancy, prolonged labor and childbirth. Pregnant women and nursing mothers should not use.
2, has inhibition to the platelet aggregation, can prolong the bleeding time, but can disappear when stop drug in 24 hours.
3, can make the higher content of blood urea nitrogen and serum creatinine, creatinine clearance decreased.
4, any of the following situations should be used carefully:
the original bronchial asthma, and after medication may increase.
the cardiac insufficiency, high blood pressure, can cause the water retention and edema after starting drug therapy.
the haemophilia or other hemorrhagic diseases (including blood coagulation disorder and platelet dysfunction), after prolonged bleeding, bleeding tendency aggravating.
a history of peptic ulcer, the application of this product is easy to appear the gastrointestinal side effects, including produce new ulcers.
renal insufficiency after kidney increased adverse reactions, and even lead to kidney failure.
long-term medication should be regularly check blood picture, liver and kidney function.
Drug Interactions1, drink alcohol or with other non-steroidal anti-inflammatory drugs available increase the gastrointestinal side effects, and have the risk of ulcer. Long term may be used with acetaminophen to increase of the side effects of kidney is dirty.
2, with acid aspirin or other drugs, not strengthen, and adverse reaction of gastrointestinal tract and an increased incidence of bleeding tendency.
3, with heparin and coumarin anticoagulants and platelet aggregation inhibition of drug use increase the risk of bleeding.
4, with cefuroxime sami unavailable, weakens the latter's platoon sodium and step-down function.
5, with verapamil, nitrate benzene organism, increased blood concentrations of this product.
6, ibuprofen can heighten digoxin blood concentration, it must pay attention to adjust the dose of digoxin.
7, ibuprofen can strengthen antidiabetic drug (including oral medications).
8, this product may be used with antihypertensive drugs affect the antihypertensive effect of the latter.
9, probenecid can reduce the discharge of the product, increase the blood drug concentration, thus increasing toxicity, so with the use of reduced doses.
10, this product can reduce the discharge of methotrexate, and increase the blood concentration, even can reach toxic levels, so this product should not be with or high-dose methotrexate.
Side Effects1, the digestive tract symptoms include indigestion, stomach burning sensation, stomach pain, nausea, vomiting, appeared in the long-term 16% users, withdrawal symptoms disappeared, the most drugs can be tolerance. A few (< 1%) in gastric ulcer and gastrointestinal bleeding, also have for ulcer perforation.
2, the nervous system symptoms such as headache, drowsiness, dizziness, tinnitus, rare in 1%~1% of patients.
3, renal insufficiency is rare, in potentially nephropathy; But a few users can appear lower extremity edema.
4, other rare symptoms include skin rashes, bronchial asthma, elevated liver enzymes, leukopenia, etc.
5, medication should be stopped during such as gastrointestinal bleeding, liver, kidney damage, visual impairment, abnormal blood picture and allergic reaction, and so on and so forth.
Chemical PropertiesColourless, Crystalline Solid
UsesA selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency
DefinitionChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Ibuprofen Preparation Products And Raw materials
Preparation ProductsAminoprofen
Raw materialsEtanol-->Aluminium chloride-->Acetyl chloride-->2,2-Dimethyl-1,3-propanediol-->Isobutylbenzene-->2-Chloropropionic acid
Tag:Ibuprofen(15687-27-1) Related Product Information
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