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Epalrestat

Epalrestat Suppliers list
Company Name: Alfa Chemistry
Tel: +1-5166625404
Email: Info@alfa-chemistry.com
Products Intro: Product Name:Epalrestat
CAS:82159-09-9
Purity:98%
Company Name: Shanghai Jinhuan Chemical CO.,LTD.
Tel: +86-21-52210535 +8613162045318
Email: sales@jinhchem.com
Products Intro: Product Name:Epalrestat
CAS:82159-09-9
Package:25KG;10KG;5KG;1KG
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86-13288715578 +86-13231137666
Email: sales@hbmojin.com
Products Intro: Product Name:Epalrestat
CAS:82159-09-9
Purity:99% Package:25KG
Company Name: Shanghai Joiny Pharmaceutical Co.,LTD
Tel: +8613681955282
Email: gyd@joiny-pharma.com
Products Intro: Product Name:(E,E)-2-[5-(2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
CAS:82159-09-9
Purity:98% Package:25kg
Company Name: Nantong Guangyuan Chemicl Co,Ltd
Tel: +undefined17712220823
Email: admin@guyunchem.com
Products Intro: Product Name:Epalrestat
CAS:82159-09-9
Purity:99% Package:1kg;10USD

Epalrestat manufacturers

  • Epalrestat
  • Epalrestat pictures
  • $10.00 / 1kg
  • 2024-03-08
  • CAS:82159-09-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 1000kg
  • Epalrestat
  • Epalrestat pictures
  • $9.90 / 10g
  • 2024-01-20
  • CAS:82159-09-9
  • Min. Order: 5g
  • Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customiz
  • Supply Ability: 100kg
Epalrestat Basic information
Product Name:Epalrestat
Synonyms:5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet;e)-(e;EPALRESTAT;(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid;AKOS BBS-00007767;OTAVA-BB BB7211260020;Epalrest;Epalrestat, 99.5%
CAS:82159-09-9
MF:C15H13NO3S2
MW:319.4
EINECS:675-018-0
Product Categories:API;Hormone Drugs;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API's;Treatment of diabetic neuropathy;82159-09-9
Mol File:82159-09-9.mol
Epalrestat Structure
Epalrestat Chemical Properties
Melting point 210-217 C
Boiling point 516.8±60.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear (warmed)
pka3.62±0.10(Predicted)
form powder
color yellow to orange
Merck 14,3605
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIInChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKeyCHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILESS1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S
Safety Information
RIDADR 2811
WGK Germany 3
RTECS XJ5131855
HS Code 2932.99.7000
HazardClass 6.1
PackingGroup II
MSDS Information
ProviderLanguage
Epalrestat English
Epalrestat Usage And Synthesis
DescriptionEpalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.
Chemical PropertiesRed Solid
OriginatorOno (Japan)
UsesAn aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.
UsesEpalrestat has been used as an aldose reductase inhibitor:
  • in the dahomey larvae diet fed forDrosophila
  • for non-irradiated and X-ray irradiated human aldose reductase
  • to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

UsesEpalrestat is an aldose reductase inhibitor with IC50 of 72 nM
DefinitionChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.
Brand nameKinedak
Biochem/physiol ActionsEpalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.
References1) Kikkawa?et al. (1983)?Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica,?24?290 2) Terashima?et al. (1984)?Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther.,?229?226 3) Ramirez and Borja (2008)?Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy,?28?646
Epalrestat Preparation Products And Raw materials
Raw materialsAcetic acid-->1,4-Dioxane-->Benzaldehyde-->Sodium chloroacetate-->Rhodanine-3-acetic acid-->Cinnamaldehyde-->Sodium glycinate
Tag:Epalrestat(82159-09-9) Related Product Information
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