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Urapidil hydrochloride

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Urapidil hydrochloride Suppliers list
Company Name: Hebei baicao biology science and technology co., ltd
Tel: +86-19131911055 +8617824879454
Email: zhang@hbbocao.com
Products Intro: Product Name:Urapidil Hydrochloride
CAS:64887-14-5
Purity:99% Package:1kg;80USD
Company Name: Chengdu Aupone Pharmaceutical Co.Ltd.
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Products Intro: Product Name:Urapidil
CAS:64887-14-5
Purity:99.99 Package:1gram
Company Name: Biopole Pharmatech Co., Ltd.
Tel: +8615151475053
Email: biopole@163.com
Products Intro: Product Name:Urapidil hydrochloride
CAS:64887-14-5
Purity:99.99%HPLC Package:1g
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +8613288715578
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Products Intro: Product Name:Urapidil hydrochloride
CAS:64887-14-5
Purity:99% Package:25KG
Company Name: airuikechemical co., ltd.
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Products Intro: Product Name:Urapidil Hydrochloride
CAS:64887-14-5
Purity:99.99% Package:1g;0.00;USD|5g;0.00;USD|25g;0.00;USD

Urapidil hydrochloride manufacturers

  • Urapidil Hydrochloride
  • Urapidil Hydrochloride pictures
  • $30.00/ kg
  • 2024-04-19
  • CAS:64887-14-5
  • Min. Order: 1kg
  • Purity: 99.7%
  • Supply Ability: 200000kg
  • Urapidil Hydrochloride
  • Urapidil Hydrochloride pictures
  • $50.00 / 1kg
  • 2024-04-18
  • CAS:64887-14-5
  • Min. Order: 1kg
  • Purity: 99.912%
  • Supply Ability: 10ton
  • Urapidil hydrochloride
  • Urapidil hydrochloride pictures
  • $50.00 / 1kg
  • 2024-04-18
  • CAS:64887-14-5
  • Min. Order: 1kg
  • Purity: 99.10%
  • Supply Ability: 50000kg
Urapidil hydrochloride Basic information
Product Name:Urapidil hydrochloride
Synonyms:6[[3-[4-(O-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYLURACIL HYDROCHLORIDE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE;6-[[3-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]PROPYL]AMINO]-1,3-DIMETHYL-2,4(1H,3H)-PYRIMIDINEDIONE HYDROCHLORIDE;URAPIDIL HYDROCHLORIDE;URAPIDIL HYDROCHLORIDE A1 ADRENOCEPTOR A NTAG;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-dione hydrochloride;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride;6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethyl-pyrimidine-2,4-quinone hydrochloride
CAS:64887-14-5
MF:C20H30ClN5O3
MW:423.94
EINECS:636-348-0
Product Categories:Adrenoceptor;Intermediates & Fine Chemicals;Pharmaceuticals;64887-14-5
Mol File:64887-14-5.mol
Urapidil hydrochloride Structure
Urapidil hydrochloride Chemical Properties
Melting point 156-1580C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: soluble
form solid
color white
Water Solubility Soluble to 50 mM in water
InChIInChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H
InChIKeyKTMLZVUAXJERAT-UHFFFAOYSA-N
SMILESO(C1C=CC=CC=1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1)C.Cl
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS YQ9862000
MSDS Information
ProviderLanguage
SigmaAldrich English
Urapidil hydrochloride Usage And Synthesis
DescriptionUrapidil is an antagonist of α1-adrenergic receptors (α1-ARs) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. It selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex. Urapidil inhibits cAMP accumulation induced by forskolin in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM). It is also a β1-AR antagonist that inhibits the positive chronotropic response induced by isoproterenol in isolated rat atria (pA2 = 6.05). Urapidil (1 μmol/kg, i.v.) lowers mean arterial pressure (MAP) in anesthetized cats, an effect that is reduced by central administration of the 5-HT1A receptor antagonist spiroxatrine.
Chemical PropertiesWhite to Off-White Crystalline Powder
UsesAntihypertensive;Serotonergic receptor agonist
Usesα1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.
Usesa1-Adrenergic antagonist; derivative of Uracil. Antihypertensive
Biological Activityα 1 -adrenoceptor antagonist and 5-HT 1A receptor agonist (pIC 50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.
Side effectsSide effects that may occur during treatment with uradil antihypertension include dizziness, fatigue, nausea, and light-headedness effects. The increases in systolic blood pressure heart rate caused by three progressive work loads bicycle exercise were not affected during urapidil, A slight reduction in forced expiratory volume was observed in some patients during treatment with beta-blocker. There was no case orthostatic hypotension during urapidil administration, despite its alpha1-blocking action. Side-effects were rare negligible[1].
References[1] G LEONETTI. Comparison of the antihypertensive effect of urapidil and metoprolol in hypertension.[J]. European Journal of Clinical Pharmacology, 1986, 30 6: 637-640. DOI:10.1007/BF00608208.
Urapidil hydrochloride Preparation Products And Raw materials
Tag:Urapidil hydrochloride(64887-14-5) Related Product Information
Propyl gallate ALTRENOGEST 1-AdaMantanethylaMine p-Anisidine p-Anisaldehyde Uracil Glycine (Trifluoromethoxy)benzene 4-Methoxyphenylacetone Tris(hydroxymethyl)aminomethane 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Topotecan hydrochloride Anisole Urea formaldehyde Urea 1,3-Dimethyluracil Sibutramine hydrochloride Tramadol hydrochloride