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Otilonium bromide

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CAS:26095-59-0
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Products Intro: Product Name:Otilonium bromide
CAS:26095-59-0
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CAS:26095-59-0
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Products Intro:Product Name:Otilonium bromide
CAS:26095-59-0
Otilonium bromide Basic information
Pharmacological effects Toxicology Side effects Precautions Uses
Product Name:Otilonium bromide
Synonyms:ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,p-(o-(octyloxy)benzamido)ben;diethyl(2-hydroxyethyl)methylammoniumbromidep-(o-(octyloxy)benzamido)benzoa;ethanaminium,n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl);octylonium;ottiloniobromuro;n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-ethanaminium bromide;OCTYLONIUM BROMIDE;OCTYLONIUM IODIDE
CAS:26095-59-0
MF:C29H43BrN2O4
MW:563.57
EINECS:247-457-4
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:26095-59-0.mol
Otilonium bromide Structure
Otilonium bromide Chemical Properties
Melting point 130-133°C
storage temp. -20?C Freezer
CAS DataBase Reference26095-59-0(CAS DataBase Reference)
Safety Information
MSDS Information
Otilonium bromide Usage And Synthesis
Pharmacological effectsOtilonium bromide is an anticholinergic and antispasmodic drug. Its trade name is Siba Min. It can regulate the flow of calcium between intestinal smooth muscle extracellular and intracellular calcium pools. It is selective to gastrointestinal smooth muscle, and it has strong antispasmodic effect. It is applied to all motor function hyperthyroidism, and spasm reaction for different reasons and different parts as well as smooth muscle fibers pathological atrophy caused spasm reaction. It is also applied to the treatment of gastrointestinal distal intestine irritable bowel syndrome (IBS) or spastic pain, spastic colon, gastroenteritis, stomach, duodenum and esophagus disease, and endoscopic examination preparation (esophagoscopy, gastroscopy, ten finger colonoscopy and proctoscope). The experimental data show that the drug is absorbed very little by oral medication, and the most absorbed drug passed the biliary tract and were excreted via the stool.
The above information is edited by the chemicalbook of Kui Ming.
ToxicologyAcute toxicity: Non-lethal dose of oral administration to rats 1500mg/kg, to dogs is 1000mg/kg.
Chronic toxicity: experimental animals according to the program: 180 days of continuous oral administration, 11.44mg/kg/otilonium bromide. We found no abnormal changes in the results of blood biochemical and histological examination.
Teratogenicity: according to 11.44mg/kg, no embryonic and teratogenic toxicity to rats and rabbits in experiments.
Gene mutations: a large number of experiments have shown no mutagenic effect.
Side effectsTherapeutic doses of otilonium bromide doesn’t cause side effects, and it doesn’t cause atropine-like effect.
PrecautionsPatients with glaucoma, prostatic hypertrophy, pyloric stenosis, pregnant or lactating women, and patients known allergic reaction to otilonium bromide should be used with caution.
UsesTreatment of gastrointestinal spasm.
Chemical PropertiesWhite Powder
UsesOtilonium bromide is an antimuscarinic
UsesOctylonium bromide is an antimuscarinic. Octylonium bromide is a platelet-activating factor antagonist as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agent. m bromide is used as an antispasmodic.
Usesantimuscarinic used as a spasmolytic agent
UsesInhibits platlet activating factor induced hypotension. Antispasmodic
Otilonium bromide Preparation Products And Raw materials
Tag:Otilonium bromide(26095-59-0) Related Product Information
Acetonitrile Mefenpyr-diethyl 1,1-Dimethoxyethane Methyl p-(2-Methoxyethyl) phenol Otilonium bromide Methanol Methoxydiethylborane ACETYLCHOLINE BROMIDE Procaine hydrochloride BENZOYLCHOLINE BROMIDE Diethyl(2-(4-(2-heptyloxybenzamido)benzoyloxy)ethyl)methylammonium bro mide N-[(2-methoxyphenyl)methyl]-4-methylaniline 4-(ACETYLAMINO)-BENZOIC ACID ETHYL ESTER Diethyl carbonate Diethyl malonate Methyl bromide 1,2-EPOXYBUTANE