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Ezetimibe

Ezetimibe Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Email: wgp@nanjing-pharmaceutical.com
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one
CAS:163222-33-1
Purity:98%(Min.HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:163222-33-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Sichuan Tuskwei Import and Export Trade Co., Ltd.
Tel: 86-311-83306736
Email: sales@tuskwei.com
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:99.78% Package:In Aluminium Foil Packing
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Ezetimibe
CAS:163222-33-1
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Ezetimibe Basic information
Description Indications and Usage Mechanisms of Action References
Product Name:Ezetimibe
Synonyms:(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one;Ticagrelor and its interMediate;Ezetimibe 1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxy-propyl]-4-(4-hydroxyphenyl)-azetidin-2-one;Ezatimibe;zetia/vytorin;SCH 60969;Ezetimibe, >=99%;(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azeti
CAS:163222-33-1
MF:C24H21F2NO3
MW:409.43
EINECS:
Product Categories:Final material;API;Isotope;CEDAX;Cardiovascular APIs;Ezetimibe;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:163222-33-1.mol
Ezetimibe Structure
Ezetimibe Chemical Properties
Melting point 164-166°C
alpha D22 -33.9° (c = 3 in methanol)
storage temp. -20?C Freezer
CAS DataBase Reference163222-33-1(CAS DataBase Reference)
Safety Information
Risk Statements 36/37/38
Safety Statements 26-36-24/25
MSDS Information
Ezetimibe Usage And Synthesis
DescriptionEzetimibe is ananti-hyperlipidemic drug used for lowering the plasma cholesterol levels. It is indicated as an adjunctive therapy to diet for the reduction of high-level total-C, LDL-C, and ApoB in patients suffering primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors.Ezetimibe does not inhibit the cholesterol synthesis in the liver, or increase bile acid excretion.It takes effect throughacting at the brush border of the small intestine and inhibiting the absorption of cholesterol, further leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of blood cholesterol.
Indications and UsageEzetimibe is a new form of selective cholesterol absorption inhibitor developed in a collaboration between Schering-Plough Co. and Merck Co. This drug is the first cholesterol absorption selective inhibitor to be approved for sale by the American FDA. Its commercial name is Ezetrol.
This drug can be used alone or in combination with HMG-CoA reductase inhibitors (statins) to treat primary (heterozygous familial and non-familial) hypercholesterolemia, homozygous familial hypercholesterolemia (HoFH), homozygous viremia (or phytosterolemia).
Mechanisms of ActionEzetimibe’s mechanisms of action are different from those of other lipid-lowering drugs (such as statins, cholic acid chelating agents, phenoxy acid derivatives, and plant sterols). This drug binds with the surface proteins on the brush border membrane vesicles of the small intestine (relative molecular mass 145x10^3) to inhibit the small intestine’s absorption of cholesterol in food and bile, thus decreasing the cholesterol content in serum and the liver. Ezetimibe is different from bile acid sequestrants because it does not affect the absorption of cholesterol esters, other steroids (such as bezoar and cholic acid), three triacylglycerol, and fat-soluble vitamins. Its effects are unrelated to whether or not acetyl coenzyme A- cholesterol acetyltransferase (ACAT) is inhibited or whether or not the LDL receptor (scavenger receptor) is expressed. After Ezetimibe is absorbed and binds with glucuronic acid in the liver, it undergoes enterohepatic circulation and almost exclusively targets small intestine mucosa cells.
Referenceshttps://en.wikipedia.org/wiki/Ezetimibe
https://pubchem.ncbi.nlm.nih.gov/compound/Ezetimibe#section=Top
https://www.drugbank.ca/drugs/DB00973
Davidson, Michael H, et al. "Ezetimibe coadministered with simvastatin in patients with primary hypercholesterolemia ☆." Journal of the American College of Cardiology 40.12(2002):2125.
Sudhop, T, et al. "Inhibition of intestinal cholesterol absorption by ezetimibe in humans. " Circulation 106.15(2002):1943-8.
Chemical PropertiesWhite Solid
UsesAn antihyperlipoproteinemic. A Cholesterol absorption inhibitor
Usesantibacterial
UsesA cholesterol transport inhibitor that binds to NPC1L1
UsesFor use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia.
Ezetimibe Preparation Products And Raw materials
Tag:Ezetimibe(163222-33-1) Related Product Information
4-Difluoromethoxy-3-hydroxybenzaldehyde (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate EZETIMIBE PHENOXY GLUCURONIDE,Ezetimibe -D-Glucuronide, >85%,EZETIMIBE B-D-GLUCURONIDE 2-AZETIDINONE, 1-(4-FLUOROPHENYL)-3-[(3S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL]-4-[4-(PHENYLMETHOXY)PHENYL]-, (3R,4S)- EZETIMIBE 2,3,4-TRI-O-ACETYL-B-D-GLUCURONIDE METHYL ESTER EZETIMIBE HYDROXY GLUCURONIDE,Ezetimibe Hydroxy b-D-Glucuronide,Ezetimibe Hydroxy -D-Glucuronide Ezetimibe-13C6 N,N-Dimethylformamide Propyl butyrate Isopropanol Polyacrylamide Acrylamide Nicotinamide Etimicin POLY(N-ISOPROPYL ACRYLAMIDE) CHLOROPHOSPHONAZO III Ezetimibe