3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐
中文名称 | 3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐 |
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中文同义词 | 3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐;JNK抑制剂(CC-401 HYDROCHLORIDE);CC-401盐酸盐;化合物CC-401 HYDROCHLORIDE;3-(3-(2-(哌啶-1-基)乙氧基)苯基)-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐 |
英文名称 | CC401 HCl |
英文同义词 | CC-401 (hydrochloride);3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride (1:1);CC 401 HYDROCHLORIDE; CC401 HYDROCHLORIDE; CC401 HCL;CC-401 dihydrochloride >=95% (HPLC);3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole hydrochloride;CC401 Hydrochloride,CC-401,Inhibitor,JNK,CC 401 Hydrochloride,CC 401,CC401,inhibit;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole hydrochloride |
CAS号 | 1438391-30-0 |
分子式 | C22H25ClN6O |
分子量 | 424.9265 |
EINECS号 | |
相关类别 | 细胞生物学试剂;API |
Mol文件 | 1438391-30-0.mol |
结构式 |
3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐 性质
储存条件 | Store at -20°C |
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溶解度 | DMSO:100 mg/mL(235.33 mM;需要超声波) |
形态 | 白色粉末 |
JNK 25-50 nM (Ki) |
CC-401 has at least 40-fold selectivity for JNK compared with other related kinases, including p38, extracellular signal-regulated kinase (ERK), inhibitor of κB kinase (IKK2), protein kinase C, Lck, zeta-associated protein of 70 kDa (ZAP70). In cell-based assays, 1 to 5 μM CC-401 provides specific JNK inhibition. CC-401, a small molecule that is a specific inhibitor of all three JNK isoforms. CC-401 competitively binds the ATP binding site in JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of the transcription factor c-Jun. The specificity of this inhibitor is tested in vitro using osmotic stress of the HK-2 human tubular epithelial cell line. CC-401 inhibits sorbitol-induced phosphorylation of c-Jun in a dosage-dependent manner. However, CC-401 does not prevent sorbitol-induced phosphorylation of JNK, p38, or ERK.
The staining of p-JNK is moderately induced in bevazicumab and Oxaliplatin treatments as compared to control, and in the CC-401-treated samples p-cJun content is significantly lower, consistent with effective JNK inhibition. DNA damage is modestly elevated in combined treatments with CC-401. CC-401 treatment from days 7 to 24 slows the progression of proteinuria, which is significantly reduced compared to the no-treatment and vehicle groups at days 14 and 21. However, there is still an increase in the degree of proteinuria at day 21 in CC-401-treated rats compared to proteinuria at day 5. The vehicle and no-treatment groups developed renal impairment at day 24 as shown by an increase in serum creatinine. This is prevented by CC-401 treatment.
安全信息
海关编码 | 2933399990 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/01/25 | HY-13022 | 3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐 CC-401 hydrochloride | 1438391-30-0 | 5mg | 900元 |
2024/01/25 | HY-13022 | 3-[3-[2-(1-哌啶基)乙氧基]苯基]-5-(1H-1,2,4-三唑-5-基)-1H-吲唑盐酸盐 CC-401 hydrochloride | 1438391-30-0 | 10mM * 1mLin DMSO | 990元 |