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Ciclesonide

Ciclesonide Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:141845-82-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: LGM Pharma  
Tel:1-(800)-881-8210
Email:inquiries@lgmpharma.com
Products Intro:Product Name:Ciclesonide
CAS:141845-82-1
Purity:Typically NLT 98%
Company Name: SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.  
Tel:021-34666753 33588661 33585969 33585366 13311639313 400-615-1668
Email:Info@shyrchem.com
Products Intro:Product Name:Ciclesonide
CAS:141845-82-1
Purity:98%,99%
Company Name: Wuhan DKY Technology Co.,Ltd.  
Tel:027-81302488 18007166089
Email:info@dkybpc.com;2851686510@qq.com
Products Intro:CAS:141845-82-1
Company Name: Wuhan Dahua Pharmaceutical Co., Ltd.  
Tel:027-59262863 13277907145 QQ:3091977954
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Products Intro:CAS:141845-82-1
Ciclesonide Basic information
Asthma medication Side Effects
Product Name:Ciclesonide
Synonyms:Ciclesonide;(R)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde, 21-isobutyrate;Alvesco;Omnaris;Pregna-1,4-diene-3,20-dione, 16,17-(((R)-cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha)-;Pregna-1,4-diene-3,20-dione, 16,17-((cyclohexylmethylene)bis(oxy))-11-hydroxy-21-(2-methyl-1-oxopropoxy)-, (11beta,16alpha(R))-;Rpr 251526;Unii-S59502J185
CAS:141845-82-1
MF:C32H45O7
MW:540.69
EINECS:
Product Categories:
Mol File:Mol File
Ciclesonide Structure
Ciclesonide Chemical Properties
Safety Information
MSDS Information
Ciclesonide Usage And Synthesis
Asthma medicationCiclesonide is a new inhaled glucocorticoid drug for treating asthma,it belongs to adrenocorticotropic hormone drugs, similar drugs also include beclomethasone dipropionate, budesonide, fluticasone propionate, the product is administrated in a non-active form ,it can be activated by endogenous esterases in the airway on the spot , it becomes into an active ingredient when it reaches the target organ-the lung; once it is activated, it shows a high topical anti-inflammatory activity.
Ciclesonide is successfully developed by the pharmaceutical company Altana, it was listed in January 2005 for the first time in the UK, it is currently available in Germany, Ireland, it is used for the treatment of adults with all levels of persistent severe asthma, one administration per day , a dose of 160μg or 80μg. For patients with severe asthma attack facing the risk of asthma, if the condition can not be controlled and strong anti-inflammatory drugs are required , the dose of this product be increased to 160μg.
In clinical trail phase III of severe patients with persistent asthma, ciclesonide has new release and distribution properties,it can reduce the local and systemic adverse reactions, and it can maintain high anti-asthma activity, it can significantly low the need on oral corticosteroids (OCS) in patients to maintain or improve effects of asthma control. Accordingly, it is an appropriate OCS saving therapy.
Side EffectsCiclesonide becomes effective faster than budesonide,its systemic side effects are lower than the fluticasone propionate and budesonide, even though the highest doses of 160μg is used, plasma glucocorticoid inhibition is also higher than other corticosteroids inhalants (if high plasma corticosterone hormone levels are high ,the systemic side effects is high).
Local side effects comparison table is as follows:
Side effects of this product fluticasone propionate budesonide
Dysphonia (hoarseness) 1.6% 4% 1%-8%-6%
Sore throat 1.9% 10%-14% 5%-10%
Thrush 0.2%-5% 2% 2%-4%
The above information is edited by the chemicalbook of Tian Ye.
Ciclesonide Preparation Products And Raw materials
Tag:Ciclesonide(141845-82-1) Related Product Information
Ciclesonide Ciclesonide 16a(R),17-(Butylidenebis(oxy))-11b,21-dihydroxypregna-1,4-diene-3,20-dione Desonide Halcinonide