Mechanism of action of Isoniazid
Isoniazid, isonicotinic acid hydrazide (INAH or INH), was discovered independently in 1952 at both Squibb and Roche Laboratories. Animal studies showed that isoniazid was a very potent antituberculosi
Mar 25，2022 API
Use and Safety of Grepafloxacin
Grepafloxacin (OPC-17116) is a broad-spectrum fluoroquinolone with the chemical structure (+)-1-cyclopropyl-6-fluoro-1,4-dihydro-5- methyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolone carboxylic acid
Mar 25，2022 API
Uses of Temafloxacin
Temafloxacin (6-fluoro-7-piperazino-4-quinolone)was discontinued in June 1992, only five months after gaining marketing approval. This was due to a high rate of reported adverse reactions, including s
Mar 25，2022 API
Uses of Fleroxacin
Fleroxacin (Ro 23-6240, AM 833) is different from fluoroquinolones such as ciprofloxacin or ofloxacin, since it is a trifluorinated quinolone, having three fluorine atoms rather than one attached to t
Mar 25，2022 API
Side effects of Tosufloxacin
Tosufloxacin was developed by Taisho-Toyama Chemistry (Ozexs) and became commercially available in 1990. It is a newer-generation oral fluoroquinolone with a broad spectrum of activity against Gramneg
Mar 25，2022 API
Imipenem: Antimicrobial Activity, Susceptibility, Administration and Dosage, Toxicity, Clinical Uses etc.
In the 1970s, Beecham Research Laboratories identified a carbapenem group, called olivanic acids, which were beta-lactamase inhibitors and broad-spectrum antibiotics (Butterworth et al., 1979).
Mar 25，2022 API
Side effects and Uses of Rufloxacin
Rufloxacin (MF 934), or 9-fluoro-10-(-methyl) piperazinyl-7-oxo-2,3- dihydro-7H-pyrido-(1,2,3, de) (1,4) benzothiazine-6-carboxylic acid, is an older-generation fluoroquinolone developed in 1989 with
Mar 25，2022 API
Side effects of Lomefloxacin
Lomefloxacin (Maxaquins, Pfizer) is an older-generation difluoroquinolone that has the chemical formula 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid. C
Mar 25，2022 API
Side effects of Sparfloxacin
Sparfloxacin (AT-4140, CI-978, PD 131501) is a newer-generation aminodifluoroquinolone with broad spectrum antibacterial activity. It has the chemical formula 5-amino-1-cyclopropyl-7-(cis-3,5-dimethyl
Mar 25，2022 API
Aztreonam: Antimicrobial Activity, Susceptibility, Administration and Dosage, Clinical Uses etc.
Aztreonam belongs to the class of beta-lactam antibiotics known as monobactams. Unlike penicillins and cephalosporins the monobactams have only the beta-lactam ring.
Mar 25，2022 API