Stevioside: biosynthesis, metabolism and safety
Stevioside is synthesized via the MEP pathway. Gut bacteria metabolize stevioside into steviol in animals. Steviol absorption varies across species, with low toxicity potential.
Jul 26，2023 API
Caffeine EP impurity A
Caffeine EP Impurity A chemically known as theophylline has been utilized in the treatment of asthma and chronic obstructive pulmonary disease.
Jul 26，2023 Analytical Chemistry
Ipratropium bromide Impurity D
Ipratropium bromide Impurity D Synonyms: 2-Phenylpropenoic Acid,Ipratropium Bromide Imp. D (EP), Ipratropium Impurity D, Atropic Acid, Ipratropium Bromide Impurity D, α-Methylenebenzeneacetic acid, A
Jul 26，2023 Analytical Chemistry
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine: quantification, mechanism of action and applications
5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine is an impurity in Ibrutinib and is a BTK inhibitor used for malignant B-cell diseases like CLL and lymphoma.
Jul 26，2023 API
Procaine hydrochloride: mechanism of action, clinical applications and side effect
Procaine hydrochloride, a local anesthetic, can inhibit nerve impulse transmission and modulate sodium channels. Used in surgery, dermatology, diagnostics, cardiovascular procedures.
Jul 25，2023 API
p-Anisic acid: metabolism and activities
p-Anisic acid inhibits tyrosinase, modulates insulin secretion, and possesses antihemorrhagic properties. It is used to treat bleeding disorders and has potential for further research.
Jul 25，2023 API
Abemaciclib: pharmacology, pharmacokinetics and mechanism of action
Abemaciclib inhibits CDK4/6, blocks cell cycle progression, induces senescence and apoptosis in cancer cells.
Jul 24，2023 API
Isotretinoin: mechanism of action and clinical applications
Isotretinoin effectively treats skin diseases by reducing inflammation, regulating cell growth, and inhibiting bacteria. It is commonly used for severe acne and other conditions.
Jul 24，2023 API
Caffeic acid: pharmacokinetics and clinical applications
Caffeic acid, a natural polyphenol, has health benefits including antioxidant effects, potential cancer prevention, diabetes management, and weight loss promotion.
Jul 24，2023 API
Exploring the applications and toxicology of tolylene-2,4-diisocyanate
Tolylene-2,4-diisocyanate used in gelatin membranes, potentiometric sensors, superhydrophobic coatings, but highly toxic and requires careful handling.
Jul 24，2023 API