| Identification | More | [Name]
PERIODIC ACID | [CAS]
10450-60-9 | [Synonyms]
IODIC ACID
ORTHOPERIODIC ACID
PARA-PERIODIC ACID
PERIODIC ACID, DIHYDRATE
periodic
periodicacid(h5io6)
Periodicacidwwaqsoln
PERIODIC ACI
PERIODIC ACID, REAGENTPLUS TM >= 99.0%
PERIODIC ACID, CRYSTALLIZED
PERIODIC ACID, 99.999%
PERIODIC ACID SOLUTION
PERIODIC ACID, 99%, A.C.S. REAGENT
PERIODIC ACID SIGMAULTRA
PERIODIC ACID ACS REAGENT
PERIODIC ACID REAGENT GRADE 98%
PERIODIC ACID, ACS, CRYSTALLIZED
ORTHO-PERIODIC ACID PURE
PeriodicAcidGr
PeriodicAcidForSynthesis | [EINECS(EC#)]
233-937-0 | [Molecular Formula]
H5IO6 | [MDL Number]
MFCD00011344 | [Molecular Weight]
227.94 | [MOL File]
10450-60-9.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless crystals | [Melting point ]
122 °C (lit.) | [Boiling point ]
140°C | [bulk density]
1400kg/m3 | [density ]
d417 1.3875; d 1.42 | [vapor pressure ]
7.6Pa at 25℃ | [RTECS ]
NN1269700 | [Fp ]
140°C | [storage temp. ]
2-8°C
| [solubility ]
soluble in Methanol, Water | [form ]
Solid | [color ]
White to slightly yellow | [PH]
1.2 (100g/l, H2O, 20℃) | [Stability:]
Stable, but strong oxidizer. Contact with combustible material may cause fire. Hygroscopic. Incompatible with organic materials, strong reducing agents. | [Water Solubility ]
Soluble in water and alcohols. | [Sensitive ]
Moisture & Light Sensitive | [Merck ]
14,7171 | [InChI]
1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7) | [InChIKey]
TWLXDPFBEPBAQB-UHFFFAOYSA-N | [SMILES]
OI(O)(O)(O)(O)=O | [CAS DataBase Reference]
10450-60-9(CAS DataBase Reference) | [EPA Substance Registry System]
Periodic acid (H5IO6) (10450-60-9) |
| Safety Data | Back Directory | [Symbol(GHS) ]
   
GHS03,GHS05,GHS08,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H271-H314-H372-H410 | [Precautionary statements ]
P210-P260-P273-P280-P303+P361+P353-P305+P351+P338 | [Hazard Codes ]
C,O | [Risk Statements ]
R8:Contact with combustible material may cause fire.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S17:Keep away from combustible material . | [RIDADR ]
UN 3264 8/PG 2
| [WGK Germany ]
3
| [F ]
3-8 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
5.1 | [PackingGroup ]
II | [HS Code ]
28111990 | [Storage Class]
5.1A - Strongly oxidizing hazardous materials | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Ox. Sol. 1
Skin Corr. 1B
STOT RE 1 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
PERIODIC ACID is colourless crystals
| [Physical properties]
In
dilute solution, periodic acid exists as H+ and IO4-.
When more concentrated, orthoperiodic acid, H5IO6, is
formed. Note that this compound is essentially a dihydrate,
HIO4·2H2O. This can be obtained as a crystalline
solid. O-periodic acid can be dehydrated to metaperiodic
acid, m-HIO4. Further heating gives di-iodine pentoxide
(I2O5) and O2. The anhydride di-iodine heptoxide,
i.e. I2O7, does not exist in nature but can be formed
synthetically. | [Uses]
In organic synthesis. | [Uses]
PERIODIC ACID is used as an oxidiser and in the determination of manganese.
| [Definition]
ChEBI: Orthoperiodic acid is an iodine oxoacid. It is a conjugate acid of an orthoperiodate(1-). | [Production Methods]
A 100-g quantity of Ba3H4(IO6)2 is moistened with 75 ml H2O and treated with 200 ml of colourless nitric acid. The agitated mixture is heated to 60-70°C for an hour and is then cooled to 30-40°C. The precipitated Ba(NO3)2 is filtered off on a glass frit. The residue is washed free of periodate by stirring with concentrated nitric acid. The combined filtrate is evaporated at 60-70°C in an aspirator vacuum [if more Ba(NO3)s separates, it is filtered, and the evaporation continues] until H5IO6 begins to precipitate. After cooling, glistening crystals of periodic acid are formed. Since the solution tends to become supersaturated, it is often necessary to wait a long time. The crystals are filtered off and dried in a vacuum at 50°C. A second crystal crop may be obtained from the mother liquor by evaporation.
| [Reactions]
Paraperiodic acid H5IO6, is obtained from sodium paraperiodate, formed by action of chlorine upon a NaOH solution containing I2. On vacuum drying, paraperiodic acid yields metaperiodic acid, HIO4, and dimesoperiodic acid, H4I2O9; which form heteropoly acids with a number of oxides and acids. The periodic acids and their salts are strong oxidizing agents both with inorganic and organic compounds. | [General Description]
Periodic acid (H5IO6) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions. | [Flammability and Explosibility]
Notclassified | [reaction suitability]
reagent type: oxidant | [References]
[1] JACKSON E. Periodic Acid Oxidation[J]. Organic Reactions, 2011, 104 1: 341-375. DOI:10.1002/0471264180.OR002.08.
[2] FATIADI A J. Periodic Acid, a Novel Oxidant of Polycyclic, Aromatic Hydrocarbons.[J]. Journal of Research of the National Bureau of Standards. Section A, Physics and Chemistry, 1968, 72A 4: 341-350. DOI:10.6028/jres.072A.030.
[3] MAHDIEH TABATABAEI SHAFIEI. Detecting glycogen in peripheral blood mononuclear cells with periodic acid schiff staining.[J]. Jove-Journal of Visualized Experiments, 2014, 94. DOI:10.3791/52199.
[4] ZACHARY J WOLNER Benjamin K S Danielle E Mustin. Preordering Periodic Acid-Schiff Staining: A Quality Improvement Study.[J]. American Journal of Dermatopathology, 2023: 825-827. DOI:10.1097/DAD.0000000000002570.
[5] SH. N. ZHURAKULOV. Oxidation of Quinoline Alkaloids Bucharaine, Foliosidine, Evoxine, and Dubinidine by Periodic Acid[J]. Chemistry of Natural Compounds, 2024, 60 4: 676-682. DOI:10.1007/s10600-024-04410-7. |
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