| Identification | More | [Name]
4-Methoxybenzyl alcohol | [CAS]
105-13-5 | [Synonyms]
4-ANISE ALCOHOL
4-ANISIC ALCOHOL
4-ANISYL ALCOHOL
4-METHOXYBENZYL ALCOHOL
(4-METHOXYPHENYL)METHANOL
ANIS ALCOHOL
ANISE ALCOHOL
ANISIC ALCOHOL
ANISYL ALCOHOL
FEMA 2099
METHOXYBENZYL ALCOHOL
METHOXYBENZYLALCOHOL(4-)
P-ANISE ALCOHOL
P-ANISIC ALCOHOL
P-ANISYL ALCOHOL
PARA METHOXY BENZYL ALCOHOL
P-METHOXYBENZYL ALCOHOL
RARECHEM AL BD 0083
4-methoxy-benzenemethano
4-Methoxybenzenemethanol | [EINECS(EC#)]
203-273-6 | [Molecular Formula]
C8H10O2 | [MDL Number]
MFCD00004653 | [Molecular Weight]
138.16 | [MOL File]
105-13-5.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS TO YELLOWISH LIQUID AFTER MELTING | [Melting point ]
22-25 °C(lit.)
| [Boiling point ]
259 °C(lit.)
| [density ]
1.113 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.24-0.53Pa at 25℃ | [FEMA ]
2099 | [refractive index ]
n20/D 1.544(lit.)
| [Fp ]
230 °F
| [storage temp. ]
Store at RT. | [solubility ]
alcohol: freely soluble | [form ]
Liquid After Melting | [pka]
14.43±0.10(Predicted) | [color ]
Clear colorless to yellow | [Specific Gravity]
1.108 | [Odor]
at 100.00 %. sweet powdery hawthorn lilac rose floral hyacinth | [PH]
6.3 (10g/l, H2O, 20℃) | [explosive limit]
0.9-7.3%(V) | [Odor Type]
powdery | [Water Solubility ]
insoluble | [JECFA Number]
871 | [Merck ]
14,604 | [BRN ]
636654 | [Contact allergens]
As a fragrance allergen, anisyl alcohol has to be mentioned
by name in cosmetics within the EU. | [InChIKey]
MSHFRERJPWKJFX-UHFFFAOYSA-N | [LogP]
-0.08-1.05 at 24-27℃ | [CAS DataBase Reference]
105-13-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenemethanol, 4-methoxy-(105-13-5) | [EPA Substance Registry System]
105-13-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R63:Possible risk of harm to the unborn child.
R62:Possible risk of impaired fertility.
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
1
| [RTECS ]
DO8925000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HS Code ]
29094990 | [Safety Profile]
Moderately toxic by
ingestion. A skin irritant. Combustible
liquid. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also ALCOHOLS. |
| Hazard Information | Back Directory | [Hazard]
Extremely toxic. | [Occurrence]
Reported found in anise (Pimpinella anisum L.), honey, Bourbon vanilla (Vanilla planifolia Andrews), Tahiti
vanilla (Vanilla tahitensis Moore), Illicium verum and tomato. | [Definition]
ChEBI: 4-Methoxybenzyl alcohol is a member of benzyl alcohols. | [Preparation]
By reduction from anisic aldehyde | [Taste threshold values]
Taste characteristics at 10 ppm: spice, anise, vanilla, balsamic and powdery | [Synthesis Reference(s)]
Synthetic Communications, 18, p. 613, 1988 DOI: 10.1080/00397918808064019
Tetrahedron Letters, 32, p. 3243, 1991 DOI: 10.1016/S0040-4039(00)79734-6 | [General Description]
Anisyl alcohol is a volatile aromatic compound mainly found in vanilla extracts and anise oil. It is used as a flavoring agent and fragrance ingredient. |
| Questions And Answer | Back Directory | [Star anise oil]
Star anise oil, also known as anise oil, appears as colorless transparent or light yellow liquid at above 20°C. When the temperature will drop, there will be sheet crystal precipitate with anise aroma and sweetness of the anethole. It is slightly soluble in water and easily soluble in ethanol, ether and chloroform. It belongs to Illicium Linn, magnoliaceae. The fruit is an aggregate fruit, being octagonal, therefore it is commonly known as star anise, also known as aniseed. Star anise oil is a kind of aromatic oil with complex composition, being volatile oil and a little sticky. Its color is gray for the best case while is yellow for slightly worse cases. It tastes sweet and tingling with a strong aroma of star anise. It is agitated at a temperature of 10 to 15 °C upon stirring. Its main ingredient is trans-anethole with a content of up to 80%. It also contains α-pinene, limonene, linalool, safrole, anisic aldehyde, anisone, 4-terpineol, artemisia capillaris, anisaldehyde and other ingredients. Anise oil is a kind of aromatic oil which is strongly technical and is not easy to identify using chemical equipment. The current producing area is still mainly through the buyer with the naked eye and nose smell to identify the quality of star anise.
Anise oil, in the spice industry, is mainly used to extract anethole brain and re-synthesis of anisaldehyde and anisol alcohol (p-methoxybenzyl alcohol, 4-methoxybenzyl alcohol). Some of the spices are widely used in toothpaste, food and soap and cosmetics fragrance. The fruit is commonly used in people's food seasoning spices. At the same time, the anise oil is the major raw material for the synthesis of negative hormone estrone in the pharmaceutical industry. As the octagonal oil is lighter than water, so it can be suspended in the water. The water obtained after oil and water separation contains anise oil after the anise oil returns to the distillation pot for re-distillation to improve the oil yield. | [Content analysis]
According to the Total Alcohol Assay (OT-5): the amount of acetylated alcohol used for saponification was 1.5 g. The equivalent factor (e) in the calculation is 69.09, or by gas chromatographic nonpolar column method in GT-10-4. | [Toxicity]
ADI 1 mg/kg (CE);
LD50 1200 mg/kg (rat, oral); | [Usage limit]
FEMA (mg/kg): soft drink 7.4; cold drink 8.0; candy 11; baked goods 12; pudding class 1.9.
Take moderate as limit (FDA § 172.515, 2000). | [Chemical properties]
It appears as colorless to slightly yellow liquid or opaque crystals with the relative density of 1.110-1.120, refractive index of 1.543-1.545, the boiling point of about 258-259 °C, freezing point> 23.5 °C, the flash point of 100 °C above and insoluble in water. It is soluble in the same volume of 50% alcohol with an acidity value of 1.0.
It mainly has fennel aroma with a slight cream fragrance and fragrant background. Aromatic odor is mild and can stay long. | [Uses]
1. 4-Methoxybenzyl alcohol mainly used in floral flavor with fragrance flavor, such as hawthorn flowers, jasmine, acacia, shy flowers, acacia, lilac, lily of the valley, violet, magnolia, sunflower, daffodils and so on. It can also be used for the need for chypre spices with vanilla flavor to coordinate the aroma and increase the aroma of beans. It can also be used for chocolate, cocoa and fresh fruit flavor.
2. GB 2760-1996 provides as allowable food flavors. It is mainly used for the preparation of vanilla, chocolate, cocoa, almonds, peaches and other flavor.
3. It is used for the preparation of drugs and spices.
4. It is used as pharmaceutical intermediates.
5. 4-Methoxybenzyl alcohol has a slightly sweet aroma of anise, commonly used in the preparation of jasmine, lilac and other flavors, suitable for deployment of perfume. The goods are allowable food spices provided in China's GB2760-86. It is mainly used to formulate the flavor of vanilla, chocolate, cocoa, almonds and peaches. It can also be used in organic synthesis and as a solvent.
6. It is used as moxonidine intermediates.
7. It is alcohol synthesis spices. It is mainly used as the blending spices of jasmine, cloves, fragrant peas, gardenia and other flavors for perfume and other cosmetics.
8. It can provide the temporary protection for the carbohydrate anti-OH-group. | [Production method]
It is obtained through the anisaldehyde reduction. The anise, formaldehyde and sodium hydroxide are subject to Cannizzaro reaction in the ethanol to generate p-methoxybenzyl alcohol. After distilling to recycle the ethanol, the resulting oil layer is extracted with benzene, acidified with acetic acid, neutralized by sodium hydrogencarbonate to a weak basicity, washed with water to neutral, then distillation to recover benzene with the residue subjecting to distillation under reduced pressure to obtain p-methoxy Benzyl alcohol.
In methanol solution, apply potassium hydroxide solution for treatment of the mixture of anisaldehyde and formaldehyde, getting mixture of anole alcohol and formic acid. Apply benzene extraction and then purify through distillation.
Use platinum as a catalyst and ferrous chloride as a reductant, obtain it through anisidine hydrogenation. |
|
|