| Identification | Back Directory | [Name]
Ethyl 5-cyanoindole-2-carboxylate | [CAS]
105191-13-7 | [Synonyms]
Ethyl 5-cyanoindole-2-carboxylate
ETHYL 5-CYANO-1H-INDOLE-2-CARBOXYLATE
Methyl 5-cyano-1H-indole-2-carboxylate
5-CYANOINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
5-CYANO-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
5-cyano-1H-indole-2-carboxylic acid methyl ester
1H-Indole-2-carboxylic acid, 5-cyano-, ethyl ester
2-Hydroxy-4-methyl-6-oxo-1,6-dihydro-3-pyridinecarbonitrile | [Molecular Formula]
C12H10N2O2 | [MDL Number]
MFCD04966999 | [MOL File]
105191-13-7.mol | [Molecular Weight]
214.22 |
| Chemical Properties | Back Directory | [Boiling point ]
419.3±25.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
13.63±0.30(Predicted) | [Appearance]
Off-white to light brown Solid |
| Hazard Information | Back Directory | [Uses]
Ethyl 5-cyanoindole-2-carboxylate is an important chemical raw material for the preparation of pril drugs and dye products, and is also widely used in the pharmaceutical industry. | [Synthesis]
General procedure for the synthesis of ethyl 5-cyano-1H-indole-2-carboxylate: a suspension of cuprous cyanide (27 mg, 0.3 mmol) and ethyl 5-bromoindole-2-carboxylate (138) in 500 μL of DMF was stirred and reacted for 7 hours at 155 °C. After completion of the reaction, it was purified by silica gel column chromatography (3 × 15 cm, SiO?, 20% EtOAc/hexane as eluent) to afford the target product, ethyl 5-cyano-1H-indole-2-carboxylate (139) (34 mg, 63% yield), as a white solid with melting point of 181-182 °C. | [References]
[1] Patent: US2005/26987, 2005, A1. Location in patent: Page 23 |
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