| Identification | More | [Name]
4-Chlorophenol | [CAS]
106-48-9 | [Synonyms]
1-CHLORO-4-HYDROXY-BENZENE
4-CHLOROPHENOL
4-CHLORPHENOL
4-Hydroxychlorobenzene
AKOS BBS-00004332
CHLOROPHENOL(4-)
PARA CHLORO PHENOL
P-CHLOROPHENOL
4-chloro-1-hydroxybenzene
4-chloro-pheno
4-Chlorophenol(form2)
4-chloro-phenole
Applied 3-78
applied3-78
chlorophenols,solid
p-Chlorfenol
p-chlorfenol(czech)
p-chlorophenicacid
p-chloro-pheno
Phenol, 4-chloro- | [EINECS(EC#)]
203-402-6 | [Molecular Formula]
C6H5ClO | [MDL Number]
MFCD00002318 | [Molecular Weight]
128.56 | [MOL File]
106-48-9.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white to light tan crystals or powder | [Melting point ]
42-45 °C | [Boiling point ]
220 °C (lit.) | [density ]
1.306 g/mL at 25 °C(lit.)
| [vapor density ]
4.43 (vs air)
| [vapor pressure ]
1 mm Hg ( 49.8 °C)
| [refractive index ]
1.5579 | [Fp ]
240 °F
| [storage temp. ]
0-6°C | [solubility ]
ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to faintly brownish-yellow | [form ]
Low Melting Crystalline Mass | [pka]
9.18(at 25℃) | [color ]
White to pale yellow | [Odor]
Phenolic like
30 ppm | [PH]
5 (20°C in H2O) | [Stability:]
Stable. Incompatible with acid chlorides, acid anhydrides, oxidizing agents, iron. | [Odor Threshold]
30 ppm | [Water Solubility ]
2.7 g/100 mL (20 ºC) | [Sensitive ]
Air Sensitive | [Usage]
Intermediates of Liquid Crystals | [Merck ]
14,2154 | [BRN ]
507004 | [Henry's Law Constant]
6.7×100 mol/(m3Pa) at 25℃, Chao et al. (2017) | [Dielectric constant]
9.5（54.0℃） | [Major Application]
agriculture
environmental
forensics and toxicology
pharmaceutical (small molecule) | [Cosmetics Ingredients Functions]
ANTIMICROBIAL | [InChI]
1S/C6H5ClO/c7-5-1-3-6(8)4-2-5/h1-4,8H | [InChIKey]
WXNZTHHGJRFXKQ-UHFFFAOYSA-N | [SMILES]
Oc1ccc(Cl)cc1 | [LogP]
2.5 at 35℃ | [CAS DataBase Reference]
106-48-9(CAS DataBase Reference) | [NIST Chemistry Reference]
p-Chlorophenol(106-48-9) | [Storage Precautions]
Store under nitrogen | [EPA Substance Registry System]
106-48-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
  
GHS05,GHS07,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H302+H312+H332-H314-H411 | [Precautionary statements ]
P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
Xn,N | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R50:Very Toxic to aquatic organisms. | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S24/25:Avoid contact with skin and eyes .
S60:This material and/or its container must be disposed of as hazardous waste . | [RIDADR ]
UN 2020 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
SK2800000
| [F ]
10-23 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29081000 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Corr. 1B | [Safety Profile]
Poison by inhalation
and intraperitoneal routes. Moderately toxic
by ingestion, skin contact, and subcutaneous
routes. A severe skin and eye irritant.
Human systemic effects by inhalation:
excitement, irritability. Mutation data
reported. Combustible when exposed to
heat or flame. To fight fire, use water, spray,
mist, fog, foam, dry chemical. When heated
to decomposition it emits toxic fumes of
Cl-. See also CHLOROPHENOLS and
CHLORIDES. | [Hazardous Substances Data]
106-48-9(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 0.67 g/kg (Deichmann) |
| Hazard Information | Back Directory | [General Description]
White crystals with a strong phenol odor Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs. | [Reactivity Profile]
CHLOROPHENOLS, SOLID are incompatible with acid chlorides, acid anhydrides and oxidizing agents. Also incompatible with iron . Liquefy and darken in color at temperatures above 108°F. | [Air & Water Reactions]
Slightly soluble to soluble in water. | [Hazard]
Toxic by skin absorption, inhalation, or
ingestion; strong irritant to tissue. | [Health Hazard]
Inhalation causes headache, dizziness, weak pulse. Ingestion causes irritation of mouth and stomach; headache, dizziness, weak pulse. Contact with eyes causes severe irritation and burning. Contact with skin causes irritation and burn; if absorbed, causes same symptoms as inhalation. | [Potential Exposure]
Monochlorophenols are used in the
manufacture of fungicides, slimicides, bactericides, pesticides, herbicides, disinfectants, wood and glue preservatives; in the production of phenolic resins; in the extraction
of certain minerals from coal; as a denaturant for ethanol;
as an antiseptic; as a disinfectant, and others. | [Fire Hazard]
Special Hazards of Combustion Products: Toxic and irritating hydrogen chloride and chlorine gases may form in fires. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has
stopped and CPR if heart action has stopped. Transfer
promptly to a medical facility. When this chemical has
been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. | [Shipping]
UN 2020 (solid); UN2021 (liquid) Chlorophenols, solid and liquid, Hazard Class: 6.1; Labels:
6.1-Poisonous materials. | [Incompatibilities]
May form explosive mixture with air.
Contact with oxidizing agents can cause fire and explosion
hazard. Heat produces hydrogen chloride and chlorine.
Corrosive to aluminum, copper and other chemically active
metals. | [Chemical Properties]
All isomers have a characteristic odor. | [Chemical Properties]
off-white to light tan crystals or powder | [Waste Disposal]
Incinerate in admixture with
flammable solvent in furnace equipped with afterburner
and scrubber. | [Uses]
antineoplastic | [Uses]
Biocide; disinfectant for home, hospital and farm. | [Uses]
Intermediates of Liquid Crystals | [Definition]
ChEBI: A monochlorophenol substituted at the pare position by a chlorine atom. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 50, p. 2145, 1985 DOI: 10.1021/jo00212a029
Tetrahedron Letters, 24, p. 3117, 1983 DOI: 10.1016/S0040-4039(00)88111-3 | [Flammability and Explosibility]
Notclassified | [Purification Methods]
Distil the phenol, then crystallise it from pet ether (b 40-60o) or hexane, and dry it under vacuum over P2O5 at room temperature. [Bernasconi & Paschalis J Am Chem Soc 108 2969 1986, Beilstein 6 IV 820.] |
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