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Chlorzoxazone

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Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:95-25-0
CAS:95-25-0
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Guangzhou PI PI Biotech Inc
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Products Intro: Product Name:Chlorzoxazone
CAS:95-25-0
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:5-Chloro-2(3H)-benzoxazolone
Company Name: Zjartschem
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CAS:95-25-0
Purity:98% Package:500g;1kg;5kg;10kg;100kg;1000kg... Remarks:Brand:Zjartschem | Cat.No.:ZCF00148
Company Name: Shanghai Zheyan Biotech Co., Ltd.
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Products Intro: Product Name:5-Chloro-2-Benzoxazolinoone
CAS:95-25-0
Purity:98% Package:25g/100g/500g
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Products Intro: Product Name:Chlorzoxazone
CAS:95-25-0
Purity:99% Package:1kg;1USD|2kg;2USD

Lastest Price from Chlorzoxazone manufacturers

  • Chlorzoxazone
  • US $0.00 / KG
  • 2021-09-29
  • CAS:95-25-0
  • Min. Order: 1KG
  • Purity: 98.0%
  • Supply Ability: 1000kg/month
  • Chlorzoxazone
  • US $0.00 / ASSAYS
  • 2021-09-26
  • CAS:95-25-0
  • Min. Order: 100ASSAYS
  • Purity: 99.99
  • Supply Ability: 10000
  • Chlorzoxazone
  • US $41269.80 / T
  • 2021-09-14
  • CAS:95-25-0
  • Min. Order: 100KG
  • Purity: 99%
  • Supply Ability: 5t
Chlorzoxazone Basic information
Skeletal muscle relaxants Pharmacokinetics Indications Chlorzoxazone synthesis Medicine interactions Side effects Uses Category Toxicity grading Acute toxicity Flammability and hazard properties Storage characteristics Extinguishing agent
Product Name:Chlorzoxazone
Synonyms:Biomioran;Chlorzoxazon;component of Parafon Forte;Escoflex;Mioran;Miotran;Myoflexin;Myoflexine
CAS:95-25-0
MF:C7H4ClNO2
MW:169.57
EINECS:202-403-9
Product Categories:PARAFON;Oxazole&Isoxazole;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:95-25-0.mol
Chlorzoxazone Structure
Chlorzoxazone Chemical Properties
Melting point 191-192 °C (lit.)
density 1.3771 (rough estimate)
refractive index 1.5557 (estimate)
storage temp. room temp
solubility DMSO: soluble50mg/mL, clear
form Powder
pkapKa 8.3 (Uncertain)
color white to off-white
Water Solubility 0.1 g/100 mL
Merck 14,2194
CAS DataBase Reference95-25-0(CAS DataBase Reference)
NIST Chemistry ReferenceChlorzoxazone(95-25-0)
EPA Substance Registry SystemChlorzoxazone (95-25-0)
Safety Information
Hazard Codes Xn,T,Xi
Risk Statements 22-36/37/38-20/21/22
Safety Statements 26-36-24/25-37/39
WGK Germany 3
RTECS DM5250000
Hazard Note Toxic/Irritant
TSCA Yes
HazardClass IRRITANT
HS Code 29349990
ToxicityLD50 in mice (mg/kg): 3650 orally, 380 i.p. (suspensions); 440 orally, 183 i.p. (solns of Na salt) (Hofrichter)
MSDS Information
ProviderLanguage
5-Chloro-2(3H)-benzoxazolone English
SigmaAldrich English
ACROS English
ALFA English
Chlorzoxazone Usage And Synthesis
Skeletal muscle relaxantsChlorzoxazone is an orally active central skeletal muscle relaxant with its chemical structure being completely different with all the other muscle relaxants. It, mainly through acting on the central cerebral cortex and the spinal cord, inhibits the multi-synaptic reflection related to muscle spasms and produces muscle relaxation, further relieves the spasm caused pain and increase the flexibility of the muscles involved. Acetaminophen belongs to non-steroidal anti-inflammatory drugs and may mainly exert the analgesic and antipyretic effects through the inhibition of prostaglandin synthesis. Muscle relaxation studies through mouse traction test have demonstrated that the compound Chlorzoxazone showed a dose-dependent muscle relaxant effect with excellent protective effect on the strychnine-induced seizures in mice. The existence of paracetamol in the compound chlorzoxazone tablets can further enhance the effect of chlorzoxazone. Hot plate analgesic tests have showed the compound chlorzoxazone has a significant analgesic effect in a dose-dependent manner. It also has antagonism effect on the painful writhing of mice caused by antimony potassium tartrate in a good dose-response relationship. Test results have showed that acetaminophen and chlorzoxazone analgesic synergy.
This information is edited by Xiongfeng Dai from Chemicalbook.
PharmacokineticsThis product can be completely absorbed by the digestive tract with the plasma concentration reaching peak at 1.5-2 hours. It is distributed in muscle, kidney, liver, brain and fat. After 6 hours, the drug concentration decreases significantly. Almost all of the goods can subject to in vivo catabolism with the elimination half-life being about 1 hour.
This information is edited by Xiongfeng Dai from Chemicalbook.
IndicationsChlorzoxazone is suitable for the treatment of various kinds of acute and chronic soft tissue (muscles, ligaments and fascia) sprain, contusion, muscle pain after exercise, pain caused by muscle strain and the muscle spasms caused by the central nervous system lesions as well as chronic fasciitis.
Chlorzoxazone synthesisTake 2, 5-dichloro-nitrobenzene as raw material; go through hydrolysis, reduction reaction to give 2-amino-4-chloro-phenol, followed by cyclization reaction in hydrochloric acid to obtain the finished product of Chlorzoxazone with the total yield being 84%.

Medicine interactionsWhen this product is used in combination with central inhibitory drugs such as phenothiazines and barbituric acid derivative and monoamine oxidase inhibition drugs, we should reduce the usage amount of this product.
Side effectsThere may be occasionally mild drowsiness, dizziness, nausea, heart palpitations, weakness, abdominal pain and other reactions. This drug should be discontinued in case of allergic reactions. These adverse reactions are generally mild and may go away automatically or alleviated after stopping using this drug.
UsesIt can be used as pharmaceutical intermediates.
It can be used as central muscle relaxants, for being applied to a variety of soft tissue pain caused by chronic sprain, contusion and muscle strain as well as muscle spasms and pain caused by the central nervous system and so on.
CategoryToxic substances.
Toxicity gradingHighly toxic.
Acute toxicityOral-rat LD50: 763 mg/kg; Oral-Mouse LD50: 440 mg/kg.
Flammability and hazard propertiesThermal decomposition can release nitrogen oxides and chlorides smoke.
Storage characteristicsTreasury: ventilated, low temperature and dry; store it separately from food raw materials.
Extinguishing agentWater, carbon dioxide, foam, powder.
DescriptionChlorzoxazone is a muscle relaxant. It acts by blocking nerve impulses or pain sensations that are sent to brain. Typically, it is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. Chlorzoxazone, 5-chloro-2-benzoxazolione, is synthesized by a heterocyclization reaction of 2-amino-4-chlorophenol with phosgene. Skeletal muscle relaxants have conventionally been classified into one group; however, they are actually a heterogeneous group of medications commonly used to treat two different types of underlying conditions – spasticity from upper motor neuron syndromes and muscular pain or spasms from peripheral musculoskeletal conditions. Medications classified as skeletal muscle relaxants are baclofen, carisoprodol, chlorzoxazone, cyclobenzaprine, dantrolene, metaxalone, methocarbamol, orphenadrine, and tizanidine. These drugs may impair mental and/or physical abilities required for driving vehicles. As a class, skeletal muscle relaxants have central nervous system (CNS)-related side effects: drowsiness, dizziness, decreased alertness, blurred vision, and ataxia. Their use has been associated with a twofold increase in the risk for motor vehicle crashes. Muscle relaxants are included in the ‘Beers List’ of potentially inappropriate medications in older adults. Most muscle relaxants are poorly tolerated by elderly patients because they cause anticholinergic adverse effects, sedation, and weakness. Although extremely uncommon, this compound may yield to idiosyncratic and unpredictable type of liver toxicity. The concomitant use of alcohol or other CNS depressants may have an additive effect. Individuals on chlorzoxazone containing drugs should be monitored for abnormal liver enzymes (e.g., aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase, bilirubin, etc.).
Chemical PropertiesWhite to Off-White Solid
OriginatorParaflex ,McNeil, US ,1958
UsesChlorzoxazone is a benzoxazolone derivative that causes skeletal muscle relaxation and blocks spasticity in clinical studies. Chlorzoxazone enhances small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 μM for KCa2.2 and KCa3.1, respectively). The cytochrome P450 isoform CYP2E1 converts chlorzoxazone to 6-hydroxy chlorzoxazone . The urinary excretion of this 6-hydroxy metabolite is often used as a probe of CYP2E1 activity in studies of hepatotoxicity.
UsesMuscle relaxant (skeletal)
UsesFor the relief of discomfort associated with acute painful musculoskeletal conditions.
DefinitionChEBI: A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful mus le spasm.
Manufacturing ProcessA solution of 16.9 g (0.1 mol) of 2-amino-5-chlorobenzoxazole in 200 ml of 1 N HCl is refluxed until precipitation is complete. The resulting solid is collected
by filtration, dissolved in 200 ml of 1 N NaOH and the solution extracted with 50 ml of ether. Acidification of the alkaline solution gives a precipitate which is purified by crystallization from acetone to give 2-hydroxy-5-chlorobenzoxazole melting at 191° to 191.5°C.
Brand nameParaflex (Ortho-McNeil).
Therapeutic FunctionMuscle relaxant
Chemical SynthesisChlorzoxazone, 5-chloro-2-benzoxazolione (15.3.15), is synthesized by a hetercyclization reaction of 2-amino-4-chlorphenol with phosgene.

Environmental FateChlorzoxazone ismetabolized by the CYP1A2 and CYP2E1 microsomal enzymes to a toxic metabolite 6-hydroxychlorzoxazone.
Toxicity evaluationChlorzoxazone is a white to off-white solid. It is soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).
Tag:Chlorzoxazone(95-25-0) Related Product Information
CHLORZOXAZONE-4,6,7-D3 2,4-Dichloro-5-fluoroacetophenone 4'-Chloroacetophenone Nizofenone Trazodone Cibenzoline succinate 1-(5-Chloro-2,3-dihydro-2-oxo-6-benzoxazolyl)-2,5-pyrrolidinedione 3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC ACID 6-HYDROXY CHLORZOXAZONE-D2,CHLORZOXAZONE, 6-HYDROXY MAJOR METABOLIT E OF C [2-14C]CHLORZOXAZONE Trilan 5,6-DICHLOROBENZOXAZOLINONE 5-CHLORO-3-METHYLBENZO[D]OXAZOL-2(3H)-ONE 2-Benzoxazolinone, 6-bromo-5-chloro-3-(3-chloropropyl)- 3-(5-CHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANENITRILE bromchlorenone (5-CHLORO-2-OXO-BENZOOXAZOL-3-YL)-ACETIC ACID Chlorzoxazone