| Identification | More | [Name]
2,5-Dimethylpiperazine | [CAS]
106-55-8 | [Synonyms]
2,5-DIMETHYLPIPERAZINE
TIMTEC-BB SBB004303
2,5-dimethyl-piperazin
2,5-Dimethylpiperazine,c&t
cis-trans-2,5-Dimethyl piperazine
2,5-Dimethylpiperazine，mixturi of cis and trans
Piperazine, 2,5-dimethyl-
2,5-Dimethylpiperazine | [EINECS(EC#)]
203-409-4 | [Molecular Formula]
C6H14N2 | [MDL Number]
MFCD00005955 | [Molecular Weight]
114.19 | [MOL File]
106-55-8.mol |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H228-H303-H311-H315-H319 | [Precautionary statements ]
P210-P240-P241-P264-P280-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P312-P405-P501 | [Hazard Codes ]
C-F | [Risk Statements ]
R34:Causes burns.
R21:Harmful in contact with skin.
R11:Highly Flammable. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking . | [TSCA ]
TSCA listed | [Toxicity]
rabbit,LD50,skin,800uL/kg (0.8mL/kg),AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951. |
| Hazard Information | Back Directory | [Chemical Properties]
Trans-2,5-Dimethylpiperazine, a white crystalline solid melting at 118° C., has shown particular promise as an intermediate for linear polyamides because of its symmetry. The cis isomer, a liquid freezing at about 18° C., probably has limited use in polymers but is expected to be useful as a pharmaceutical intermediate.[2]
| [Uses]
Trans-2,5-dimethylpiperazine is primarily as a monomer for synthesizing a specific polyamide polymer, which is then used as a material for reverse osmosis membranes.[1] | [Synthesis]
In the presence of hydrogenation-dehydrogenation catalysts, isopropanolamine undergoes a bimolecular cycloamination reaction to form 2,5-dimethylpiperazine[2]:
 | [References]
[1] L. CREDALI P. P A Chiolle. Reverse osmosis properties of poly(trans-2,5-dimethylpiperazine fumaramide) films[J]. Polymer, 1972, 13 10: Pages 503-506. DOI:10.1016/0032-3861(72)90090-0.
[2] W. LANGDON D. J W Levis. 2,5-Dimethylpiperazine Synthesis from Isopropanolamine[J]. Industrial & Engineering Chemistry Process Design and Development, 1962, 64 1: 153-156. DOI:10.1021/I260002A016.
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