| Identification | Back Directory | [Name]
Neocryptotanshinone | [CAS]
109664-02-0 | [Synonyms]
Neocryptotanshinone
5,6,7,8-Tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl-1,4-phenanthrenedione
1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl- | [Molecular Formula]
C19H22O4 | [MDL Number]
MFCD32878228 | [MOL File]
109664-02-0.mol | [Molecular Weight]
314.38 |
| Chemical Properties | Back Directory | [Boiling point ]
517.1±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.50±1.00(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20,22H,4-5,8-9H2,1-3H3/t10-/m0/s1 | [InChIKey]
PKEGICXVZMKJPR-JTQLQIEISA-N | [SMILES]
C1(=O)C2=C(C3=C(C=C2)C(C)(C)CCC3)C(=O)C(O)=C1[C@@H](C)CO |
| Hazard Information | Back Directory | [Uses]
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2]. | [in vivo]
Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3]. | Animal Model: | MSU-induced pain model in male ICR mice (weighing 20-25 g)[2] | | Dosage: | 10, 25, 50 or 100 mg/kg | | Administration: | Oral gavage; for 30, 60, 120 min | | Result: | Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner. |
| [IC 50]
iNOS | [storage]
4°C, protect from light | [References]
[1] Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9. DOI:10.1016/j.apsb.2015.01.010
[2] H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50. DOI:10.1021/np000345v
[3] FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226. PMID:33825401 |
|
| Company Name: |
cjbscvictory Gold
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|