| Identification | Back Directory | [Name]
25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane | [CAS]
1056881-04-9 | [Synonyms]
mPEG8-Br
m-PEG8-bromide
octaethyleneglycolmonomethyletherbromide
25-Bromo-2,5,8,11,14,17,20,23-octaoxapentacosane
2,5,8,11,14,17,20,23-Octaoxapentacosane, 25-bromo-
25-Bromo-2581114172023-octaoxapentacosane/m-PEG8-Br | [Molecular Formula]
C17H35BrO8 | [MDL Number]
MFCD31380391 | [MOL File]
1056881-04-9.mol | [Molecular Weight]
447.36 |
| Chemical Properties | Back Directory | [Boiling point ]
462.5±40.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
m-PEG8-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG8-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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