ChemicalBook--->CAS DataBase List--->110448-33-4

110448-33-4

110448-33-4 Structure

110448-33-4 Structure
IdentificationBack Directory
[Name]

ML-7 HYDROCHLORIDE
[CAS]

110448-33-4
[Synonyms]

ML-7
ML-7, HCl
ML-7 HYDROCHLORIDE
ML 7 hydrochloride, >=98%
1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,
1-(5-IODONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL
1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-*HEX AHYDRO-1,4-
1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE
1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL
1-((5-Iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine, hyd
1-(5-IODONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE
Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine Monohydrochloride
1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-, Monohydrochloride
[Molecular Formula]

C15H18ClIN2O2S
[MDL Number]

MFCD00065524
[MOL File]

110448-33-4.mol
[Molecular Weight]

452.74
Chemical PropertiesBack Directory
[Appearance]

Off-White to Yellow Fine Crystalline Solid
[Melting point ]

246-249°C dec.
[storage temp. ]

−20°C
[solubility ]

insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
[form ]

powder
[color ]

white
Hazard InformationBack Directory
[Chemical Properties]

Off-White to Yellow Fine Crystalline Solid
[Uses]

A potent and selective inhibitor of myosin light chain kinase.
[Description]

ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 μM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 .
[Biochem/physiol Actions]

Selective myosin light chain kinase inhibitor.
[in vitro]

rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
[in vivo]

administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
[storage]

room temperature (desiccate)
[References]

[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
Safety DataBack Directory
[WGK Germany ]

3
Spectrum DetailBack Directory
[Spectrum Detail]

ML-7 HYDROCHLORIDE(110448-33-4)1HNMR
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