| Identification | More | [Name]
Nicosulfuron | [CAS]
111991-09-4 | [Synonyms]
1-(4,6-dimethoxypyrimidin-2-yl)-3-(3-dimethylcarbamoyl-2-pyridylsulfonyl)urea
2-[[(4,6-DIMETHOXYPYRIMIDIN-2-YL) AMINO-CARBONYL]AMINO SULFONYL]-N,N-DIMETHYL-3-PYRIDINE CARBOXAMIDE
2-[(4,6-dimethoxypyrimidin-2-ylcarbamoyl)sulfamoyl]-n,n-dimethylnicotinamide
ACCENT
ACCENT (TM)
DASUL
MILAGRONOSTOC
NICOSULFURON
NICOSULFURONOXAMIDE
3-pyridinecarboxamide,2-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)
hu195
n-dimethyl-sulfonyl)-
sl950
2-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-N,N-dimethyl-3-pyridinecarboxamide
Nicosulfuron, Pestanal
3-Pyridinecarboxamide-2-[([4,6-dimethoxypyrimidin-2-yl] aminocarbonyl) aminosulfonyl]-N,N-dimethyl-3-pyridinocarboxamide
NICOSLFURON
3-Pyridinecarboxamide, 2-(4,6-dimethoxy-2-pyrimidinyl)aminocarbonylaminosulfonyl-N,N-dimethyl-
nicosulfuron (bsi,ansi,draft e-iso)
NICOSULPHURON | [EINECS(EC#)]
244-666-2 | [Molecular Formula]
C15H18N6O6S | [MDL Number]
MFCD00203303 | [Molecular Weight]
410.41 | [MOL File]
111991-09-4.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline solid or powder. Phenolic
odor. | [Melting point ]
141-144°C | [density ]
1.4126 (rough estimate) | [refractive index ]
1.7000 (estimate) | [storage temp. ]
0-6°C | [solubility ]
DMSO: 50 mg/mL (121.83 mM) | [form ]
neat | [pka]
pKa (25°): 4.6 | [Usage]
Post-emergence sulfonylurea herbicide | [Stability:]
Hygroscopic, Unstable in DMSO | [InChIKey]
RTCOGUMHFFWOJV-UHFFFAOYSA-N | [CAS DataBase Reference]
111991-09-4(CAS DataBase Reference) | [EPA Substance Registry System]
111991-09-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
1 | [RTECS ]
US4615000 | [HS Code ]
29350090 | [Hazardous Substances Data]
111991-09-4(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Potential Exposure]
Nicosulfuron is a sulfonylurea postemergence
herbicide used to control a variety of weeds on
field corn and popcorn crops. Some formulations may be
registered as United States Restricted Use Pesticides (RUP) | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts
the skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from
exposure, begin rescue breathing (using universal precautions)
if breathing has stopped, and CPR if heart action
has stopped. Transfer promptly to a medical facility.
When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce vomiting.
Do not make an unconscious person vomit. Do not
induce vomiting when formulations containing petroleum
solvents are ingested. | [Shipping]
UN3077 or UN3082 Environmentally hazardous
substances, liquid or solid, n.o.s., Hazard Class: 9; Labels:
9-Miscellaneous hazardous material, Technical Name
Required. | [Incompatibilities]
Slowly hydrolyzes in water, releasing
ammonia and forming acetate salts. Decomposed ＞165℃. | [Chemical Properties]
White crystalline solid or powder. Phenolic
odor. | [Chemical Properties]
White Solid | [Waste Disposal]
It is the responsibility of chemical
waste generators to determine the toxicity and physical
properties and of a discarded chemical and to properly identify
its classification and certification as a hazardous waste and to
determine the disposal method. United States Environmental
Protection Agency guidelines for the classification determination
are listed in 40 CFR Parts 261.3. Additionally, waste generators
must consult and follow all regional, national, state
and local hazardous waste laws to ensure complete and accurate
classification and disposal methods. | [Uses]
Herbicide. | [Uses]
Post-emergence sulfonylurea herbicide | [Definition]
ChEBI: A N-sulfonylurea that is 2-(carbamoylsulfamoyl)-N,N-dimethylpyridine-3-carboxamide substituted by a 4,6-dimethoxypyrimidin-2-yl group at the amino nitrogen. | [Agricultural Uses]
Herbicide: Used as a post-emergence herbicide to control a
variety of weeds on field corn and popcorn crops. Some
formulations may be U.S. EPA restricted Use Pesticides
(RUP). Approved for use in EU countries. | [Trade name]
ACCENT®; BASIS®; CELEBRITY®;
CHALLENGER®; DASUL®; DPX 79406® Herbicide
(with Rimsulfuron); DPX-V9636®; GHIBLI®; LAMA®;
MATRIX® Herbicide (with Rimsulfuron); MILAGRO®;
MISTRAL®; MOTIVEL®; NISSHIN®; SAMSON®;
STEADFAST® (nicosulfuron + rimsulfuron) | [Metabolic pathway]
In the four systems investigated, the primary
degradation pathway is to yield pyridine sulfonamide
and 4,6-dimethoxy-2-aminopyrimidine. The plant and its
microsomal system include the hydroxylation pathway
at the 4-position of the pyrimidine ring, resulting in
hydrolysis products by the cleavage of the sulfonylurea
linkage. In mammals, contraction or rearrangement of
the sulfonylurea linkage for nicosulfuron and N-
demethylated nicosulfuron yields two unique products
which have the N-pyridyl-N-pyrimidyl urea moiety and
result in the uracil metabolite. | [storage]
Store at -20°C |
| Questions And Answer | Back Directory | [Description]
Nicosulfuron is a kind of herbicides belonging to the sulfonylurea family. It is a broad-spectrum herbicide that can controls many kinds of maize weeds including both annual weeds and perennial weed including Johnsongrass, quackgrass, foxtails, shattercane, panicums, barnyardgrass, sandbur, pigweed and morningglory. It is a systemic selective herbicide, being effective in killing plants near the maize. This selectivity is achieved through maize’s capability of metabolizing Nicosulfuron into harmless compound. Its mechanism of action is through inhibiting the enzyme acetolactate synthase (ALS) of the weeds, blocking the synthesis of amino acids such as valine and isoleucine, and finally inhibiting the protein synthesis and causing death of weeds.
| [References]
http://www.agchemaccess.com/Nicosulfuron
http://pmep.cce.cornell.edu/profiles/extoxnet/metiram-propoxur/nicosulfuron-ext.html
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