| Identification | More | [Name]
2-Amino-4,6-dihydroxypyrimidine | [CAS]
56-09-7 | [Synonyms]
2-ADHP
2-AMINO-4,6-DIHYDROXYPYRIMIDINE
2-AMINO-4,6-PYRIMIDINEDIOL
2-amino-6-hydroxy-1h-pyrimidin-4-one
2-AMINOPYRIMIDINE-4,6-DIOL
4(1H)-PYRIMIDINONE, 2-AMINO-6-HYDROXY-
AKOS 92830
AKOS BBS-00007961
LABOTEST-BB LT00080685
TIMTEC-BB SBB004247
2-amino-6-hydroxy-4(1h)-pyrimidinon
2-amino-6-hydroxy-4(1H)-Pyrimidinone
4(1H)-Pyrimidinone, 2-amino-6-hydroxy-(8CI,9CI)
2-Amino-6-hydroxy-1H-pyrimidin-4-on
2-Amino-6-hydroxy-3H-pyrimidin-4-one
2-Amino-4,6-dihydroxypyrimidine,98%
2-Amino-3,4-dihydro-6-hydroxypyrimidine-4-one
2-Amino-6-hydroxypyrimidin-4(1H)-one
4,6-Dihydroxy-2-aminopyrimidine | [EINECS(EC#)]
200-256-5 | [Molecular Formula]
C4H5N3O2 | [MDL Number]
MFCD00006094 | [Molecular Weight]
127.1 | [MOL File]
56-09-7.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
>300 °C (lit.) | [Boiling point ]
235.85°C (rough estimate) | [density ]
1.4748 (rough estimate) | [refractive index ]
1.5000 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in Aqueous Alkali. | [form ]
Powder | [pka]
7.45±0.10(Predicted) | [color ]
Off-white to light pink or light yellow | [Detection Methods]
HPLC,NMR | [BRN ]
510297 | [InChI]
InChI=1S/C4H5N3O2/c5-4-6-2(8)1-3(9)7-4/h1H,(H4,5,6,7,8,9) | [InChIKey]
AUFJTVGCSJNQIF-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(O)=CC(=O)N1 | [CAS DataBase Reference]
56-09-7(CAS DataBase Reference) | [Storage Precautions]
Heat sensitive | [EPA Substance Registry System]
56-09-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
1
| [RTECS ]
UW7361000
| [TSCA ]
Yes | [HS Code ]
29335900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Description]
2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine. | [Chemical Properties]
White Solid | [Uses]
Intermediate in the production of antimicrobial guanylsulfonamides. | [Definition]
ChEBI: 2-Amino-4,6-dihydroxypyrimidine is a hydroxypyrimidine. | [Synthesis]
The synthesis of 2-Amino-4,6-dihydroxypyrimidine is as follows:
A freshly-prepared sodiummethoxide solution in methanol (25 ml) was added to a round-bottomed flask containing guanidine hydrochloride(15 mmol), stirred for a few minutes, before dimethyl malonate (15 mmol)was slowly added. The mixture was heated under reflux for about 2-3hours. After evaporation of the solvent under reduced pressure, the resultingwhite solid was dissolved in a minimum amount of water and the pH adjusted to 6with 10% HCl. The precipitate obtained was filtered and washed with distilledwater and ethanol, respectively, to obtain pure 2-amino-4,6-pyrimidinediol.(Note: sodium methoxide solution was prepared by addition of small pieces ofsodium metal in methanol).Yield: 85%;solid, m.p. 195-197 °C.
 | [References]
[1] Patent: CN106167469, 2016, A. Location in patent: Paragraph 0012; 0013; 0014 |
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