| Identification | More | [Name]
TRIETHYLENE GLYCOL MONOMETHYL ETHER | [CAS]
112-35-6 | [Synonyms]
2-[2-(2-METHOXYETHOXY)ETHOXY]ETHANOL
METHOXY TRIGLYCOL
METHYL TRIGLYCOL
TRIETHYLENE GLYCOL MONOMETHYL ETHER
Triglycol monomethyl ether
2-(2-(2-methoxyethoxy)ethoxy)-ethano
2-[2-(2-methoxyethoxy)ethoxy]-ethano
3,6,9-Trioxa-1-decanol
Dowanol TMAT
dowanoltmat
Methoxytriethylene glycol
methoxytriethyleneglycol
Methyltrioxitol
Poly-solv tm
poly-solvtm
Triethylene glycol methyl ether
triethyleneglycolmethylether
triethyleneglycolmonomethylether(tgme)
Triethylene glycol monomethyl
PEG-3 METHYL ETHER | [EINECS(EC#)]
203-962-1 | [Molecular Formula]
C7H16O4 | [MDL Number]
MFCD00002875 | [Molecular Weight]
164.2 | [MOL File]
112-35-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Liquid. | [Melting point ]
-45°C(lit.) | [Boiling point ]
122 °C10 mm Hg(lit.)
| [density ]
1.026 g/mL at 25 °C(lit.)
| [vapor density ]
5.66 (vs air)
| [vapor pressure ]
<0.01 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.439(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [Water Solubility ]
Completely miscible in water | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless | [PH]
5-7 (H2O, 20℃) | [BRN ]
1700198 | [Henry's Law Constant]
2.8×108 mol/(m3Pa) at 25℃, HSDB (2015) | [Cosmetic Ingredient Review (CIR)]
TRIETHYLENE GLYCOL MONOMETHYL ETHER (112-35-6) | [InChI]
1S/C7H16O4/c1-9-4-5-11-7-6-10-3-2-8/h8H,2-7H2,1H3 | [InChIKey]
JLGLQAWTXXGVEM-UHFFFAOYSA-N | [SMILES]
COCCOCCOCCO | [LogP]
-1.12 at 20℃ | [Uses]
Plasticizer intermediate. | [CAS DataBase Reference]
112-35-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanol, 2-[2-(2-methoxyethoxy)ethoxy]-(112-35-6) | [EPA Substance Registry System]
112-35-6(EPA Substance) | [Usage]
2-[2-(2-METHOXYETHOXY)ETHOXY]ETHANOL(112-35-6) Mainly used for solvent,reagent. |
| Questions And Answer | Back Directory | [Synthesis]
Figure 1. Synthetic Route of Triethylene Glycol Monomethyl Ether Triethylene glycol (80 mL, 0.59 mol) and sodium hydroxide (8.0 g, 0.2 mol) were added to a single-necked flask and the mixture was stirred under heating until it became a viscous liquid. Dimethyl sulfate (20 mL, 0.20 mol) was slowly added dropwise to the reaction mixture. The solution was then heated to 120 °C with stirring and reacted at this temperature for about 4 hours. During heating, the color of the solution would deepen. After the reaction was complete, the reaction mixture was cooled to room temperature and water (50 mL) was added. The aqueous phase was extracted three times with dichloromethane. The combined organic phases were dried over anhydrous magnesium sulfate and filtered. The low-boiling solvent was concentrated using a rotary evaporator. The concentrated liquid was then distilled under vacuum to obtain the target product molecule, triethylene glycol monoether methyl ester. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P305+P351+P338 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
1
| [RTECS ]
KL6390000
| [F ]
10-23 | [Autoignition Temperature]
210 °C | [TSCA ]
TSCA listed | [REACH Registrations]
Active | [HS Code ]
29094990 | [Storage Class]
10 - Combustible liquids | [Hazardous Substances Data]
112-35-6(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 11850 mg/kg LD50 dermal Rabbit 7448 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Methanol-->ETHYLENE OXIDE | [Preparation Products]
Nonaethylene Glycol Monomethyl Ether-->Diethylene glycol monomethyl ether-->METHYLTRIGLYCOLMETHACRYLATE-->m-PEG7-OTs-->2,5,8,11,14,17-Hexaoxanonadecan-19-ol, methanesulfonate-->m-PEG3-Tos-->2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate-->2,5,8,11,14,17-Hexaoxanonadecan-19-amine-->Hexaethylene Glycol Monomethyl Ether-->Dioctyl maleate-->2,2-dimethyl-3,6,9,12-tetraoxa-2-silatridecane-->TRI(ETHYLENE GLYCOL) METHYL VINYL ETHER, 98 |
| Hazard Information | Back Directory | [General Description]
Colorless odorless liquid. | [Reactivity Profile]
Ethers, such as TRIETHYLENE GLYCOL METHYL ETHER(112-35-6), can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert. | [Air & Water Reactions]
Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. | [Health Hazard]
No appreciable hazard in ordinary handling or use. | [Description]
m-PEG3-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media. | [Chemical Properties]
Colorless liquid.Soluble in water.
Combustible. | [Definition]
ChEBI: A hydroxypolyether that is the monomethyl ether derivative of triethylene glycol. Metabolite observed in cancer metabolism. | [Safety Profile]
Mildly toxic by ingestion and skincontact. A skin and eye irritant. Many glycol ethercompounds have dangerous human reproductive effects.Combustible when exposed to heat or flame. To fight fire,use alcohol foam, dry chemical. When heated todecomposit |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|