| Identification | More | [Name]
BIOTIN-NHS, WATER-SOLUBLE | [CAS]
119616-38-5 | [Synonyms]
5-(2-OXO-HEXAHYDRO-THIENO[3,4-D]IMIDAZOL-4-YL)-PENTANOIC ACID 2,5-DIOXO-3-SULFO-PYRROLIDIN-1-YL ESTER SODIUM SALT
BIOTIN 3-SULFO-N-HYDROXY-SUCCINIMIDE ESTER SODIUM SALT
BIOTIN (LONG ARM) NHS, WATER SOLUBLE
BIOTIN-NHS, WATER-SOLUBLE
SULFOBIOTIN-NHS
SULFO-NHS-BIOTIN
SULFOSUCCINIMIDOBIOTIN
SULFOSUCCINIMIDOBIOTIN SODIUM SALT
SULPHO NHS BIOTIN
SULPHOSUCCINIMIDO BIOTIN
biotin 3-sulfo-N-hydroxysuccinimide*ester sodium
Sulfosuccinimidyl biotin
BiotinN-hydroxy-sulfosuccinimideester
biotin 3-sulfo-N-hydroxysuccinimide ester | [Molecular Formula]
C14H18N3NaO8S2 | [MDL Number]
MFCD00078535 | [Molecular Weight]
443.43 | [MOL File]
119616-38-5.mol |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
H2O: 10 mg/mL
| [form ]
powder
| [Water Solubility ]
H2O: 10mg/mL
DMF: 50mg/mL | [InChI]
1S/C14H19N3O8S2.Na.H/c18-10-5-9(27(22,23)24)13(20)17(10)25-11(19)4-2-1-3-8-12-7(6-26-8)15-14(21)16-12;;/h7-9,12H,1-6H2,(H2,15,16,21)(H,22,23,24);; | [InChIKey]
NKHCQKKDLWGBRK-UHFFFAOYSA-N | [SMILES]
[Na].OS(=O)(=O)C1CC(=O)N(OC(=O)CCCCC2SCC3NC(=O)NC23)C1=O | [CAS DataBase Reference]
119616-38-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS07,GHS08 | [Signal word ]
Warning | [Hazard statements ]
H302+H312+H332-H315-H319-H335-H361 | [Precautionary statements ]
P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R63:Possible risk of harm to the unborn child. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Sulfo-NHS-Biotin is a linker containing a sulfo-NHS moiety and a biotin group. Sulfo-NHS enables control and modification of carbodiimide crosslinking reactions involving activation of carboxylates for conjugation with primary amines. The terminal biotinylation can react with amine molecules in the presence of activator EDC or HATU. | [Chemical Properties]
1.3 ? | [Uses]
apoptosis probe, cell permeable fluorescent Ca2+-sensitive dye for cystolic Ca2+ assays | [Uses]
Sulfo-NHS-Biotin is a biotinylation reagent used for biotinylating antibody or protein that can then be used for protein detection or immobilization studies when used in conjunction with streptavidin
and immobilized streptavidin. Sulfo-NHS-Biotin was shown to work most effectively when targeting cell surface proteins. | [Uses]
Sulfo-NHS-Biotin is a biotinylation reagent used for biotinylating antibody or protein that can then be used for protein detection or immobilization studies when used in conjunction with streptavidin and immobilized streptavidin. Sulfo-NHS-Biotin was shown to work most effectively when targeting cell surface proteins. | [General Description]
Biotin:avidin second antibody signal systems involve the conjugation of biotin to a secondary antibody. Once the secondary antibody binds to a target primary antibody in an immunochemical assay, the signal is developed by allowing avidin which has been conjugated to an enzyme or signal molecule to bind to the antibody associated biotin molecule. | [Biological Activity]
sulfo-nhs-biotin (n-hydroxysulfosuccinimidobiotin) is an amine-reactive biotinylation reagent. the most common amine-reactive biotinylation reagents can be divied into two basic types, n-hydroxysuccinimide (nhs) esters and carboxylates. generally, nhs esters biotinylation reagent contains a reactive nhs ring structure that reacts with an amine on the carbonyl group of a protein or other molecules through nucleophilic attack subsequently forming a stable amide linkage and releasing the nhs group. due to the insolubility of nhs-biotin in aqueous environments, sulfo-nhs-biotin, a water-soluble analog of nhs-biotin, has been developed by attaching a negatively charged sulfonate group on the nhs ring structure, which can be added directly to aqueous reactions without the need for organic solvent dissolution.bioconjugate techniques , 2nd ed. by greg t.hermanson (pierce biotechnology, thermo fisher scientific, rockford, il). academic press (an imprint of elsevier): london, amsterdam, burlington, san diego . 2008. isbn 978-0-12-370501-3. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
|