| Identification | More | [Name]
Dorzolamide | [CAS]
120279-96-1 | [Synonyms]
(2r,4r)-2-ethylamino-4-methyl-5,5-dioxo-5,7-dithiabicyclo[4.3.0]nona-8,10-diene-8-sulfonamide
DORZOLAMIDE
DORZOLAMIDE(SUBJECTTOPATENTFREE)
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S-trans)-
4S,6S-Dorzolamide
(4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-7,
Dorzalamide hydrochloride
7-dioxide-4H-Thieno[2,3-b]thiopyran-2-sulfonamide/ Dorzolamide | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C10H16N2O4S3 | [MDL Number]
MFCD00865636 | [Molecular Weight]
324.44 | [MOL File]
120279-96-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
575.8±60.0 °C(Predicted) | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
DMSO: soluble5mg/mL (clear solution, warmed) | [form ]
powder | [pka]
pKa 6.35 (Uncertain);8.50 (Uncertain) | [color ]
white to beige | [optical activity]
[α]/D -25 to -35°, c = 1 in methanol | [CAS DataBase Reference]
120279-96-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Carbonic anhydrase inhibitor. | [Uses]
Dorzolamide is an intermediate in synthesizing N-Acetyl Dorzolamide (A173640), a useful synthetic compound. | [Definition]
ChEBI: 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration
. A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension. | [Brand name]
Trusopt (Merck). |
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