| Identification | Back Directory | [Name]
N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | [CAS]
1204085-48-2 | [Synonyms]
Biotin-PEG1-azide
N-[2-(2-Azidoethoxy)ethyl]-biotinamide
N-(2-(2-Azidoethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide | [Molecular Formula]
C14H24N6O3S | [MDL Number]
MFCD28386078 | [MOL File]
1204085-48-2.mol | [Molecular Weight]
356.444 |
| Hazard Information | Back Directory | [Uses]
Biotin-PEG1-azide is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Biotin-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
Cleavable Linker | [References]
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
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