2353409-59-1

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2353409-59-1 Structure

Identification	Back Directory
[Name] Biotin-PEG7-thiourea
[CAS] 2353409-59-1
[Synonyms] Biotin-PEG7-thiourea
[Molecular Formula] C27H51N5O9S2
[MDL Number] MFCD31811451
[MOL File] 2353409-59-1.mol
[Molecular Weight] 653.85

Chemical Properties	Back Directory
[density ] 1.196±0.06 g/cm3(Predicted)
[pka] 13.90±0.40(Predicted)

Hazard Information	Back Directory
[Description] Biotin-PEG7-thiourea is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin. The thiourea group can be used as a source of sulfide, such as for converting alkyl halides to thiols.
[Uses] Biotin-PEG7-thiourea is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50] PEGs
[References] [1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:10.1038/nchembio.2329

2353409-59-1 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354 +1-00000000000 , +1-00000000000
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Company Name:	Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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Website:	www.chemextension.com

Company Name:	Jilin Chinese Academy of Sciences-yanshen Technology
Tel:	18143011203
Website:	http://www.chemextension.com/

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