| Identification | More | [Name]
1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino | [CAS]
126764-17-8 | [Synonyms]
1-CHLORO-6,6-DIMETHYL-2-ENE-4-YNE-HEPTANE
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE
2-HEPTEN-4-YNE, 1-CHLORO-6,6-DIMETHYL-, (2E)-
TRANS-1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE
1-chloro-6,6-dimethyl-2-ene-4-yene-heptane
1-chloro-6,6-dimethyl-2-hepten-4-yn
1-chloro-6,6-dimethyl-2-heptyene-4-alkyne
Terbinafine intermediate
1-Chloro-6,6-Dimethyl-2-ene-4-
1-chloro-6,6-dimethyl-2-heptene-4-yne (intermediate of terbinafine hcl)
1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE( FOR TERBINAFINE HYDROCHLORIDE )
1-choro-6,6-dimethyl-2-hepten-4-yne
The intermediate of terbinafine
6,6-DIMETHYL-2-HEPTEN-4-YNE
1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino | [EINECS(EC#)]
603-158-4 | [Molecular Formula]
C9H13Cl | [MDL Number]
MFCD04039160 | [Molecular Weight]
156.65 | [MOL File]
126764-17-8.mol |
| Questions And Answer | Back Directory | [Preparation]
trans-1,3-dichloropropene, catalyst, and organic amine are added to the solvent tetrahydrofuran. Under stirring, tert-butylacetylene is added dropwise at 40°C. After the addition is complete, the reaction continues for 10-50 hours, preferably 30 hours. After the reaction is complete, tetrahydrofuran is removed by vacuum distillation. The product is dissolved in petroleum ether, washed three times with dilute ammonia solution with a weight percentage of 8-12%, dried, filtered, and then the petroleum ether is removed by vacuum distillation to obtain a crude product. The crude product is then subjected to vacuum distillation, and the fraction collected at 70-80°C (15 mmHg) is used to obtain a colorless to pale yellow product, 1-Chloro-6,6-dimethyl-2-heptene-4-yne. |
| Chemical Properties | Back Directory | [Boiling point ]
207-208°C | [density ]
0.946 | [Fp ]
75°C | [refractive index ]
1.4850 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform, Ethyl Acetate (Slightly), Hexane (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless to Pale Yellow | [Stability:]
Light Sensitive | [InChI]
InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3 | [InChIKey]
ZIXABMZBMHDFEZ-UHFFFAOYSA-N | [SMILES]
C(Cl)C=CC#CC(C)(C)C | [CAS DataBase Reference]
126764-17-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
1-Chloro-6,6-dimethyl-2-heptene-4-yne(126764-17-8) is an intermediate in the synthesis of terbinafine, an orally administered antifungal drug. It can be used to treat fungal infections of the scalp, body, groin (ringworm), feet (tinea pedis), fingernails and toenails.
| [Chemical Properties]
Pale Yellow Oil | [Uses]
An intermediate in the synthesis of Terbinafine (T107500,126764-17-8).
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