ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Antifungal Drugs >Terbinafine Hydrochloride

Terbinafine Hydrochloride

Terbinafine Hydrochloride Suppliers list
Company Name: Jinan Chenghui-Shuangda Chemical Co.,Ltd
Tel: +86-13064007766
Products Intro: Product Name:Terbinafine HCl
Purity:99.0%/EP9 Package:25KG;120USD Remarks:EP;USP
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Terbinafine Hydrochloride
Purity:99% Package:1kg;7USD
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 15562555968
Products Intro: Product Name:terbinafine hydrochloride
Purity:99% Package:5KG;1KG
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Products Intro: Product Name:Terbinafine Hydrochloride
Purity:99% Package:670/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Terbinafine Hydrochloride
Purity:99% Package:100g,500g,1KG,10KG,100KG

Lastest Price from Terbinafine Hydrochloride manufacturers

  • Terbinafine HCl
  • US $120.00-120.00 / KG
  • 2019-01-14
  • CAS:78628-80-5
  • Min. Order: 1KG
  • Purity: 99.0%/EP9
  • Supply Ability: 10 tons
Terbinafine Hydrochloride Basic information
Dermatologist Broad-spectrum Antifungal Drugs Pharmacokinetics Indications Usage and Dosage Chemical Properties Usage
Product Name:Terbinafine Hydrochloride
Synonyms:lamosil;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmon;Lamisil, N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine;1-Naphthalenemethanamine, N-(2E)-6,6-dimethyl-2-hepten-4-ynyl-N-methyl-, hydrochloride;TERNBINAFINEHCL;({[(2E)-6,6-Dimethylhept-2-en-4-yn-1-yl](methyl)amino}methyl)naphthalene hydrochloride;Trebinafine hydrochloride;1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol
Product Categories:-;Antifungal;APIs;Acetylenes;Antifungals for Research and Experimental Use;Biochemistry;LAMISIL;Functionalized Acetylenes;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Terbinafine
Mol File:78628-80-5.mol
Terbinafine Hydrochloride Structure
Terbinafine Hydrochloride Chemical Properties
Melting point 204-208°C
storage temp. -20°C Freezer
solubility methanol: soluble50mg/mL
form powder
color white
Merck 14,9156
CAS DataBase Reference78628-80-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,N
Risk Statements 36/37/38-50/53
Safety Statements 26-36/37/39-61-60
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS QJ8600100
ToxicityLD50 in mice, rats (mg/kg): 4000, 4000 orally; 393, 213 i.v. (Ganzinger)
MSDS Information
Terbinafine Hydrochloride Usage And Synthesis
Dermatologist Broad-spectrum Antifungal DrugsTerbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It is developed by Swiss Novartis in the 1980 s, and appeared in the market of UK for the first time in 1991. Approved by FDA of the United States for OTC drugs in 1996, and appeared in the market of the United States in the same year. At present, the drug is been sold in more than 90 countries of the word. It can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. Suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis.
Terbinafine hydrochloride entered the the first batch of country announced OTC directory in 2000. This product belongs to antifungal drugs. It has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.
PharmacokineticsAccording to reports in the literatures, after 250 mg of Terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. The absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. The combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. Terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. The metabolites after the bioconversion have no antifungal activity, then discharged through urine. The half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. But the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.
Indications1.Skin, hair and nail infection caused by Btrichophyta (white hair versicolor bacterium, Trichophyton mentagrophytes, Trichophyton verrucosum, trichophyton tonsurans and Trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect.
2.Skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.).
3.Onychomycosis (nail fungus infection) caused by molds.
Usage and DosageLocal external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. Ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks.
Oral: 0.25 grams each time for adult, once per day, period of treatment is as follows:
Skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2~6 weeks; Ringworm of the body, tinea, 2~4 weeks.
Skin candidiasis: 2~4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing.
Hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children.
Onychomycosis: The most treatment course of patients is 6 weeks to three months. Young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour.
In other cases, the treatment is usually 3 months. Some patients, especially whose thumb (toe) infected, may take 6 months or longer. The treatment may take more than 3 months if the nail grew slowly in the first week. In healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.
Chemical PropertiesWhite crystalline powder. Melting point is 204-208 oC.
UsageTerbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. It has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. It can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc.
This information is edited by ChemicalBook Xiao Nan.
Chemical PropertiesCrystalline Powder
UsesAn orally active, antimycotic allylamine related to Naftifine. A specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. Antifungal.
UsesTerbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.
DefinitionChEBI: A hydrochloride obtained by reaction of terbinafine with one molar equivalent of hydrogen chloride.
Terbinafine Hydrochloride Preparation Products And Raw materials
Preparation ProductsTerbinafine hydrochloride
Tag:Terbinafine Hydrochloride(78628-80-5) Related Product Information
3-PENTEN-1-YNE TERBINAFINE DIHYDROCHLORIDE TERBINAFINE, HYDROCHLORIDE D-7 Dimethyl sulfoxide Dimethyl ether Dimethyl phthalate ETHANE Methylamine hydrochloride Dimethyl sulfide Dimethyl fumarate Topotecan hydrochloride Terbinafine Hydrochloride Meglumine TRIMETHYLAMINE HYDROCHLORIDE Terbinafine hydrochloride Methylamine Methyl N,N-Dimethylformamide